Figueroa HMF, Polanco LAS, Parra JLS, Berumen-Glinz C, Vega MME

Language: Spanish
References: 12
Page: 104-108
PDF size: 263.99 Kb.

ABSTRACT

Pemphigus vulgaris (PV) is an autoimmune disease characterized by involvement of the mucous membranes and skin with suprabasal acantholytic vesicles, caused by autoantibodies targeting keratinocyte junctions. It has been associated with infection by herpes simplex virus (HSV), through molecular mimicry or activating autoimmune potential. This association has been described as a complication of pv immunosuppressive therapy, or as a trigger for pemphigus with a role in its etiopathogenesis; or alternatively, without evidence of viral infection.
We report a 16-year-old male patient diagnosed with pv who initiated immunosuppressive treatment without improvement, was clinically reassessed and HSV was identified. Treatment with acyclovir was initiated and, in conjunction with the baseline treatment, resolution of the lesions was achieved.

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