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2025, Number 4

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Rev ADM 2025; 82 (4)

The Warburg effect and its influence on oral carcinogenesis: a literature review.

Kattan-Rodríguez JE, Salgado-Chavarría F, Jacinto-Alemán LF

Language: Spanish
References: 29
Page: 232-238
PDF size: 350.16 Kb.


ABSTRACT

In the 1920's, Otto Warburg proposed that cancer cells exhibit increased glucose uptake and lactate production, using aerobic glycolysis for ATP generation. This phenomenon, known as the Warburg effect, becomes a hallmark of cancer proliferation and development. These neoplastic cells generate an acidic environment that promotes malignancy, invasion, and metastasis. Head and neck cancers (HNC) are among the top 10 malignancies, with oral cancer responsible for 50% of these cases. Understanding the main cause and mechanism of cancer development is essential for prevention and diagnosis, as well as establishing more effective treatments. Therefore, the objective of this article is to conduct a review of the Warburg effect and how it mainly affects and influences the metabolism of cancer cells, especially oral cancer.


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