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ISSN 1729-6935 (Electronic)
16 de abril

2022, Number 286

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16 de abril 2022; 61 (286)

Biological aging: the role of mitochondria and free radicals

Fajardo-Quesada AJ, Licea-González MÁ

Language: Spanish
References: 35
Page: 1-7
PDF size: 308.14 Kb.


ABSTRACT

Introduction: in the search for the cause of biological aging, numerous theories have emerged, such as that of free radicals, this has located mitochondria in many studies due to its involvement in their production. Objective: to describe the role of free radicals produced in mitochondria in cellular and biological aging. Method: An exhaustive bibliographic review was carried out by searching the SciELO database and journals from the academic publisher Multidisciplinary Digital Publishing Institute (MDPI). The descriptors used were: "Mitochondria", "Aging", "Free radicals", "Oxidative stress", "Antioxidants", in Spanish; for the English language, the following were used: “Mitochondria”; “Aging”, “Free radicals”, “Oxidative stress”, “Antioxidants”. The search period included the months between June and August 2021. 78 articles were consulted, of which only 35 were chosen. Development: mitochondria is where free radicals are most produced, these are capable of altering all biomolecules and destroying them especially the mitochondrial ones. The use of antioxidants has shown to be useful in slowing down aging and diseases associated with it. Conclusions: the primary theory that tries to explain biological aging is that of free radicals, although it has detractors with justified approaches. The involvement of mitochondria in aging is a fact and based on this, methods are sought to slow it down.


REFERENCES

  1. Jang JY, Blum A, Liu J, Finkel T.The role of mitochondria in aging. J ClinInvest [Internet]. 2018 [citado 11/08/21];128(9):3662–70. Disponible en: . https://doi.org/10.1172/JCI120842

  2. Moro L. Mitochondrial Dysfunctionin Aging and Cancer. J Clin Med [Internet].2019 [citado 11/08/21]; 8(11):1983.Disponible en: https://doi.org/10.3390/jcm8111983

  3. León Regal ML, Cedeño MoralesR, Rivero Morey RJ, Rivero Morey J,García Pérez DL, Bordón González L. Lateoría del estrés oxidativo como causadirecta del envejecimiento celular. Medisur[Internet]. 2018 [citado 11/08/2021];16(5):699-710. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1727-897X2018000500012&lng=es

  4. Warraich UE, Hussain F, KayaniHUR. Aging - Oxidative stress, antioxidantsand computational modeling. Heliyon.[Internet]. 2020 [citado 11/08/2021];6(5):e04107. Disponible en: https://doi.org/10.1016/j.heliyon.2020.e04107

  5. Rico-Rosillo MG, Oliva-Rico D,Vega-Robledo GB. Envejecimiento: algunasteorías y consideraciones genéticas, epigenéticasy ambientales. Rev Méd Inst Mex SeguroSoc [Internet]. 2018 [citado 11/08/21];56(3):287-94. https://www.redalyc.org/journal/4577/457757174017/457757174017.pdf

  6. Coutiño Rodríguez EM del R,Arroyo Helguera OE, Herbert Doctor LA.Envejecimiento biológico: Una revisiónbiológica, evolutiva y energética. Rev Fesahancccal[Internet]. 2020 [citado 05/08/21];6(2):20–31. Disponible en: http://www.revistafesahancccal.org/index.php/fesahancccal/article/view/54

  7. De Jaeger C. Fisiología del envejecimiento.EMC - Kinesiterapia - MedFísica [Internet]. 2018 [citado 11/08/21];39(2):1–12. Disponible en: https://doi.org/10.1016/S1293-2965(18)89822-X

  8. Hernández García F, RobainaCastillo JI, Vázquez Almoguera E. Estrésoxidativo y diabetes mellitus, un acercamientoal tema. Univ Médica Pinareña [Internet].2018 [citado 02/08/21]; 13(2):69–85. Disponible en: http://www.revgaleno.sld.cu/index.php/ump/article/view/262

  9. Viada Pupo E, Gómez Robles L,Campaña Marrero IR. Estrés oxidativo. CorreoCientífico Médico de Holguín [Internet].2017 [citado 02/08/21]; 21(1):171–186.Disponible en: https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=71540

  10. Carvajal Carvajal C. Especiesreactivas del oxígeno: formación, funciony estrés oxidativo. Med Leg CostaRica [Internet]. 2019 [citado 02/08/21];36(1):91–100. Disponible en: https://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S1409-00152019000100091

  11. Stefanatos R, Sanz A. The role ofmitochondrial ROS in the aging brain. FEBSLett [Internet]. 2018 [citado 10/08/21];592(5):743–58. Disponible en: https://doi.org/10.1002/1873-3468.12902

  12. Hidalgo MA. Estrés oxidativo yantioxidantes. Av en Investig Agropecu [Internet].2018 [citado 10/08/21]; 22(1):29–46. Disponible en: https://www.redalyc.org/journal/837/83757421004/83757421004.pdf

  13. Sánchez Urbina R, Avilés MartínezKI, Pérez Díaz CI, Zamora Pérez AL,Ortiz García YM, Pérez Rulfo ID. Daño alADN en neonatos de madres con sobrepeso.Rev Médica MD [Internet]. 2017 [citado09/08/21]; 8(4):140–5. Disponible en:https://www.imbiomed.com.mx/articulo.php?id=109470

  14. Grimm A, Eckert A. Brain agingand neurodegeneration: from a mitochondrialpoint of view. J Neurochem [Internet].2017 [citado 09/08/21]; 143(4):418–31.Disponible en: https://pubmed.ncbi.nlm.nih.gov/28397282/

  15. Ortiz Escarza JM, MedinaLópez ME. Estrés oxidativo ¿un asesinosilencioso? Educ química [Internet].2020 [citado 03/08/21]; 31(1):1–11. Disponibleen: https://doi.org/10.22201/fq.18708404e.2020.1.69709

  16. Singh A, Kukreti R, Saso L, KukretiS. Oxidative Stress: A Key Modulator in NeurodegenerativeDiseases. Mol [Internet].2019 [citado 02/08/21]; 24(8):1583. Disponibleen: https://www.mdpi.com/1420-3049/24/8/1583/htm

  17. Martín-Fernández B, Gredilla R.Estrés oxidativo mitocondrial y envejecimientocardíaco. Clínica e Investig en Arterioscler[Internet]. 2018 [citado 05/08/21];30(2):74–83. Disponible en: https://doi.org/10.1016/j.arteri.2017.12.002

  18. Theurey P, Pizzo P. The Aging Mitochondria.Genes (Basel) [Internet]. 2018[citado 08/08/21]; 9(1):22. Disponible en:https://doi.org/10.3390/genes9010022

  19. Haas RH. Mitochondrial Dysfunctionin Aging and Diseases of Aging.Biol [Internet]. 2019 [citado 09/08/21];8(2):48. Disponible en: https://www.mdpi.com/2079-7737/8/2/48/htm

  20. Kowalska M, Piekut T, PrendeckiM, Sodel A, Kozubski W, Dorszewska J.Mitochondrial and Nuclear DNA OxidativeDamage in Physiological and PathologicalAging. DNA Cell Biol [Internet]. 2020 [citado09/08/21]; 39(8):1410–20. Disponible en:https://doi.org/10.1089/dna.2019.5347

  21. Nilsson MI, Tarnopolsky MA.Mitochondria and Aging—The Role ofExercise as a Countermeasure. Biol [Internet].2019 [citado 11/08/21]; 8(2):40.Disponible en: https://doi.org/10.3390/biology8020040

  22. Molina I, Solórzano E. ¿La senescenciacelular promueve el envejecimientobiológico? Acta bioclinica. 2021;11(22):241-74.

  23. Zsurka G, Peeva V, Kotlyar A,Kunz WS. Is There Still Any Role for OxidativeStress in Mitochondrial DNA-DependentAging? Genes (Basel) [Internet]. 2018[citado 11/08/21]; 9(4):175. Disponible en:https://doi.org/10.3390/genes9040175

  24. Pérez Rodríguez ML, CamejoExpósito M. Consideraciones sobre larelación ejercicio físico-estrés oxidativo.Podium [Internet]. 2018 [citado 11/08/21];13(1):88–93. Disponible en: https://podium.upr.edu.cu/index.php/podium/article/view/740/776

  25. Zia A, Farkhondeh T, PourbagherShahri AM, Samarghandian S. TheRoles of mitochondrial dysfunction andReactive Oxygen Species in Aging andSenescence. Curr Mol Med [Internet].2021 [citado 17/08/21]; 22(1):37-49. Disponibleen: https://europepmc.org/article/med/33602082

  26. Sánchez Valle V, Méndez SánchezN. Estrés oxidativo, antioxidantes yenfermedad. Médica Sur [Internet]. 2013[citado 11/08/21]; 20(3):161–8. Disponibleen: https://www.medigraphic.com/cgi-bin/new/resumenI.cgi?IDARTICULO=79284

  27. Panov AV, Dikalov SI. Cardiolipin,Perhydroxyl Radicals, and Lipid Peroxidationin Mitochondrial Dysfunctions and Aging.Oxid Med Cell Longev [Internet]. 2020[citado 17/08/21]; 1323028. Disponible en:https://doi.org/10.1155/2020/1323028

  28. Son JM, Lee C. Mitochondria:multifaceted regulators of aging. BMB Rep[Internet]. 2019 [citado 10/08/21]; 52(1):13-23. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386233/

  29. Calderón-Peña A, Aspajo-VillalazC, Pretel-Sevillano O. Estrés oxidativo y especiesreactivas. REBIOL. [Internet]. 2018[citado 11/08/21]; 38(2):53–65. Disponibleen: https://dialnet.unirioja.es/servlet/articulo?codigo=8143237

  30. Chaudhari SN, Kipreos ET. TheEnergy Maintenance Theory of Aging:Maintaining Energy Metabolism to AllowLongevity. BioEssays [Internet]. 2018 [citado10/08/21]; 40(8):1800005. Disponibleen: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314662/

  31. Son JM, Lee C. Aging: All roadslead to mitochondria. Semin Cell Dev Biol.[Internet]. 2021 [citado 10/08/21]; 116:160–8. Disponible en: https://doi.org/10.1016/j.semcdb.2021.02.006

  32. Nicolson G, Breeding P, Settineri R,Mattos GF de. Aging and chronic illnesses:Membrane Lipid Replacement for restoringmitochondrial function and reducing fatigue,pain, and other symptoms in aged individuals.Bioact Compd Heal Dis [Internet].2020 [citado 17/08/21]; 3(10):194–203.Disponible en: https://www.ffhdj.com/index.php/BioactiveCompounds/article/view/749/1340

  33. Yadav S, Maurya PK. Biomedicalapplications of metal oxide nanoparticlesin aging and age-associated diseases. 3Biotech [Internet]. 2021 [citado 17/08/21];11(7):1–15. Disponible en: https://doi.org/10.1007/s13205-021-02892-8

  34. Guillaumet-Adkins A, Yañez Y,Peris-Diaz MD, Calabria I, Palanca-BallesterC, Sandoval J. Epigenetics andOxidative Stress in Aging. Oxid Med CellLongev. [Internet]. 2017 [citado 17/08/21];2017:1–8. Disponible en: https://doi.org/10.1155/2017/9175806

  35. Pascual-Ahuir A, Manzanares-EstrederS, Proft M. Pro- and AntioxidantFunctions of the Peroxisome-MitochondriaConnection and Its Impact on Aging and Disease.Oxid Med Cell Longev [Internet]. 2017[citado 11/08/21]; 2017:1–17. Disponibleen: https://doi.org/10.1155/2017/9860841




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