Garnica EMA, Sosa PER, Jimeno PRG, Sánchez PH

Language: Spanish
References: 12
Page: 54-60
PDF size: 437.59 Kb.

ABSTRACT

Sarcopenia is a syndrome characterized by a progressive deterioration in the strength and function of skeletal muscle mass. Muscle is increasingly recognized as an organ with immunoregulatory properties. Skeletal muscle cells have been shown to participate in the regulation of immune function through signaling through different myokines, muscle surface molecules, and cell-to-cell interaction. The pathophysiology of the stages of sarcopenia is still complex and partially characterized. There is an inadequate understanding of the underlying cellular and biological mechanisms that drive the development of this disease. The deterioration of the immune system that occurs with increasing age, which is known as immunosenescence, has been documented in various studies. Immunosenescence goes hand in hand closely with inflammation. Inflammation is characterized by increased levels of proinflammatory cytokines, such as interleukin 1β (IL1β), interleukin 6 (IL6), tumor necrosis factor alpha (TNFα), C-reactive protein (CRP), and a reduced level of anti-inflammatory cytokines, such as interleukin 10 (IL10). Investigation of the role of the immune system in different stages of sarcopenia shows that dysregulation of the immune system may play a role in the progression of the disease.

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