2024, Number 1-3
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Rev Mex Periodontol 2024; 15 (1-3)
Resolvins, an important adjuvant in periodontitis treatment
Macías-Montaño IA, Gutiérrez-Angulo M, Ayala-Madrigal ML, Peregrina-Sandoval J, Macías-Gómez NM, Mariaud-Schmidt RP
Language: Spanish
References: 49
Page: 30-35
PDF size: 281.75 Kb.
ABSTRACT
Gingival tissues are essential for oral health, deficient hygiene, smoking and genetic factors promote the development of periodontitis, which compromises the integrity of the dental supporting tissues. Omega-3 fatty acids are precursors of resolvins. These are specialized molecules with anti-inflammatory properties that provide several benefits to overall health. Their role in periodontitis recently has been studied as a complementary therapeutic pathway for periodontal tissue regeneration. Adopting good dental hygiene habits and consuming foods rich in omega-3 are key to maintaining health.
REFERENCES
Chiluveru S, Gundelly M, Putuluri S, Tummanepally M, Chandaka M, Koduganti R. Resolvins in periodontitis and possible periodontal regeneration: literature review. Cureus. 2024; 16 (8): e68187.
Newman MG, Takei HH, Klokkevold PR, Carranza FA. Carranza's clinical periodontology. 13th edition. Philadelphia: Saunders Elsevier; 2019, p. 62.
Ghemis L, Goriuc A, Jipu R, Georgeta L, Luchian I. The involvement of resolvins in pathological mechanisms of periodontal disease associated with type 2 diabetes: a narrative review. Intl J Mol Sci. 2024; 25 (23): 12784.
Organización Mundial de la Salud. Informe sobre la situación mundial de la salud bucodental: hacia la cobertura sanitaria universal para la salud bucodental de aquí a 2030. Resumen ejecutivo. Ginebra: Organización Mundial de la Salud; 2022.
Diao J, Song X, Guo T, Wang F, Chen L, Zhang W. Cellular engineering strategies toward sustainable omega-3 long chain polyunsaturated fatty acids production: State of the art and perspectives. Biotech Adv. 2020; 40: 107497.
Serhan CN, Hong S, Gronert K, Colgan SP, Devchand PR, Mirick G et al. Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. J Exp Med. 2002; 196 (8): 1025-1037.
Serhan CN. Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not? Am J Pat. 2010; 177 (4): 1576-1591.
Demarquoy J, Borgne FL. Biosynthesis, metabolism and function of protectins and resolvins. Clini Lipid. 2014; 9 (6): 683-693.
Hasturk H, Kantarci A. Activation and resolution of periodontal inflammation and its systemic impact. Periodontol 2000. 2015; 69 (1): 255-273.
Jauhiainen L, Ylostalo P, Mannisto S, Kanerva N, Knuuttila M, Suominen AL. Periodontal condition in relation to intake of omega-3 and omega-6 polyunsaturated fatty acids. J Clin Periodontol. 2016; 43 (11): 901-908.
Van Dyke TE. Pro-resolving mediators in the regulation of periodontal disease. Mol Asp Med. 2017; 58: 21-36.
Serhan CN. Pro-resolving lipid mediators are leads for resolution physiology. Nature. 2014; 510 (7503): 92-101.
Herrera BS, Hasturk H, Kantarci A, Freire MO, Nguyen O, Kansal S et al. Impact of resolvin E1 on murine neutrophil phagocytosis in type 2 diabetes. Inf Immunity. 2014b; 83 (2): 792-801.
Lee CT, Teles R, Kantarci A, Chen T, McCafferty J, Starr JR et al. Resolvin E1 reverses experimental periodontitis and dysbiosis. J Immunol. 2016; 197:2796-2806.
Serhan CN, Arita M, Hong S, Gotlinger K. Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers. Lipids. 2004; 39 (11): 1125-1132.
Schwab JM, Chiang N, Arita M, Serhan CN. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature. 2007; 447 (7146): 869-874.
Campbell EL, Louis NA, Tomassetti SE, Canny GO, Arita M, Serhan CN et al. Resolvin E1 promotes mucosal surface clearance of neutrophils: a new paradigm for inflammatory resolution. FASEB J. 2007; 21 (12): 3162-3170.
Basil MC, Levy BD. Specialized pro-resolving mediators: endogenous regulators of infection and inflammation. Nat Rev Immunol. 2016; 16 (1): 51-67.
Hasturk H, Kantarci A, Goguet-Surmenian E, Blackwood A, Andry C, Serhan CN et al. Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo. J Immunol. 2007; 179 (10): 7021-7029.
Duffield JS, Hong S, Vaidya VS, Lu Y, Fredman G, Serhan CN et al. Resolvin D series and protectin D1 mitigate acute kidney injury. J Immunol. 2006; 177 (9): 5902-5911.
Sun YP, Oh SF, Uddin J, Yang R, Gotlinger K, Campbell E et al. Resolvin D1 and its aspirin-triggered 17R epimer. J Biol Chem. 2007; 282 (13): 9323-9334.
Huang L, Wang CF, Serhan CN, Strichartz G. Enduring prevention and transient reduction of postoperative pain by intrathecal resolvin D1. Pain. 2011; 152 (3): 557-565.
Bohr S, Patel SJ, Sarin D, Irimia D, Yarmush ML, Berthiaume F. Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model. Wound Repair Regen. 2013; 21 (1): 35-43.
Hasturk H, Kantarci A, Ohira T, Arita M, Ebrahimi N, Chiang N et al. RvE1 protects from local inflammation and osteoclast mediated bone destruction in periodontitis. FASEB J. 2006; 20 (2): 401-403.
Gronert K, Maheshwari N, Khan N, Hassan IR, Dunn M, Schwartzman ML. A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense. J Biol Chem. 2005; 280 (15): 15267-15278.
Khaled M, Shibani N, Labban N, Batarseh G, Song F, Ruby J et al. Effects of resolvin D1 on cell survival and cytokine expression of human gingival fibroblasts. J Periodontol. 2013; 84 (12): 1838-1846.
Mustafa M, Zarrough A, Bolstad AI, Lygre H, Mustafa K, Hasturk H, et al. Resolvin D1 protects periodontal ligament. Am J Physiol Cell Physiol. 2013; 305 (6): C673-679.
Titos E, Rius B, González-Périz A, López-Vicario C, Morán-Salvador E, Martínez-Clemente M, et al. Resolvin D1 and its precursor docosahexaenoic acid promote resolution of adipose tissue inflammation by eliciting macrophage polarization toward an M2-like phenotype. J Immunol. 2011; 187 (10): 5408-5418.
Vasconcelos DP, Costa M, Amaral IF, Barbosa MA, Águas AP, Barbosa JN. Modulation of the inflammatory response to chitosan through M2 macrophage polarization using pro-resolution mediators. Biomaterials. 2015; 37: 116-123.
Jiang X, Xue Y, Mustafa M, Xing Z. An updated review of the effects of eicosapentaenoic acid- and docosahexaenoic acid-derived resolvins on bone preservation. Prostaglandins Other Lipid Mediat. 2022; 160: 106630.
Nuñez J, Vignoletti F, Caffesse RG, Sanz M. Cellular therapy in periodontal regeneration. Periodontol 2000. 2019; 79 (1): 107-116.
Trubiani O, Pizzicannella J, Caputi S, Marchisio M, Mazzon E, Paganelli R et al. Periodontal ligament stem cells: current knowledge and future perspectives. Stem Cells Dev. 2019; 28 (15): 995-1003.
McCulloch CA. Historical perspective of periodontal progenitor cells: early studies that clarified identity and function. Curr Oral Health Rep. 2015; 2 (4): 227-235.
Albuquerque-Souza E, Schulte F, Chen T, Hardt M, Hasturk H, Van Dyke TE et al. Maresin-1 and resolvin E1 promote regenerative properties of periodontal ligament stem cells under inflammatory conditions. Front Immunol. 2020; 11: 585530.
Zarrough AE, Hasturk H, Stephens DN, Van Dyke TE, Kantarci A. Resolvin D1 modulates periodontal ligament fibroblast function. J Periodontol. 2023; 94 (5): 683-693.
Bozkurt SB, Hakki SS, Kantarci A. Differential effects of resolvin D1 and resolvin E1 on cementoblast function. J Periodontol. 2023; 94 (11): 1351-1362.
Katsimbri P. The biology of normal bone remodelling. Eur J Cancer Care. 2017; 26 (6): e12740.
Daly RM, Duckham RL, Gianoudis J. Evidence for an interaction between exercise and nutrition for improving bone and muscle health. Curr Osteoporos Rep. 2014; 12 (2): 219-226.
Kantarci A, Hasturk H, Van Dyke TE. Animal models for periodontal regeneration and peri-implant responses. Periodontol 2000. 2015; 68 (1): 66-82.
Gao L, Faibish D, Fredman G, Herrera BS, Chiang N, Serhan CN et al. Resolvin E1 and chemokine-like receptor 1 mediate bone preservation. J Immunol. 2013; 190 (2): 689-694.
Chun-Teh Lee, Ricardo Teles, Alpdogan Kantarci, Tsute Chen, Jon McCafferty, Jacqueline R Starr et al. Resolvin E1 reverses experimental periodontitis and dysbiosis. J Immunol. 2016; 197 (7): 2796-2806.
Kholy KE, Freire M, Chen T, Van Dyke TE. Resolvin E1 promotes bone preservation under inflammatory conditions. Front Immunol. 2018; 9: 1300.
Zhu M, Van Dyke TE, Gyurko R. Resolvin E1 regulates osteoclast fusion via DC-STAMP and NFATc1. FASEB J. 2013; 27 (8): 3344-3353.
Funaki Y, Hasegawa Y, Okazaki R, Yamasaki A, Sueda Y, Yamamoto A, et al. Resolvin E1 inhibits osteoclastogenesis and bone resorption by suppressing IL-17-induced RANKL expression in osteoblasts and RANKL-induced osteoclast differentiation. Yonago Acta Med. 2018; 61 (1): 8-18.
Natarajan P, Madanian S, Marshall S. Investigating the link between oral health conditions and systemic diseases: a cross-sectional analysis. Sci Rep. 2025; 15 (1): 10476.
Miroult C, Lasserre J, Toma S. Effects of omega-3 as an adjuvant in the treatment of periodontal disease: A systematic review and meta-analysis. Clin Exp Dent Res. 2023; 9 (4): 545-556.
Salman SA, Akram HM, Ali OH. Omega-3 as an adjunctive to non surgical treatment of chronic periodontitis patients. IOSR J Dent Med Sci. 2014; 13 (6): 08-11.
Stando M, Piatek P, Namiecinska M, Lewkowicz P, Lewkowicz N. Omega-3 polyunsaturated fatty acids EPA and DHA as an adjunct to non-surgical treatment of periodontitis: a randomized clinical trial. Nutrients. 2020; 12 (9): 2614.
Murali AC, Bhandary R, Ramesh A, Venugopalan G. Evaluation of treatment with omega-3 fatty acid supplements on salivary levels of resolvin E1 in chronic periodontitis patients. J Health Allied Sci NU. 2022; 13 (02): 268-272.