Márquez IAA, Amavizca LA, Lobo VM, Valbuena GE, Quintero VJTJ, Olivas AFJ

Language: Spanish
References: 20
Page: 277-294
PDF size: 254.89 Kb.

ABSTRACT

Objetivo: To evaluate the scientific evidence regarding the effects of vitamin D supplementation on metabolic variables in patients with gestational diabetes mellitus.
Methodology: A systematic review was conducted on articles referring to vitamin D supplementation in patients with gestational diabetes, adhering to the Cochrane, PRISMA, and PICO criteria. Randomized clinical trials from PubMed, LILACS, Cochrane, SciELO, and SpringerLink (2012–2024) databases were analyzed. Five studies were evaluated using the PEDro and JADAD scales.
Results: Vitamin D supplementation showed significant changes in 25-hydroxyvitamin D concentrations in all studies. Fasting glucose concentrations and HOMA-IR improved in the intervention group compared to the control group in two of the five studies. However, reports of glycated hemoglobin were inconsistent. Positive effects were observed when supplementation was administered continuously at moderate doses.
Conclusions: The findings are inconclusive regarding the routine intake of vitamin D in patients with gestational diabetes mellitus. Heterogeneity in the doses and duration of supplementation across studies limits comparability. Factors such as genetic variability, baseline vitamin D status, and the formulation itself may influence the efficacy of supplements. In this regard, current evidence is insufficient to establish definitive recommendations. Additional studies are needed to determine the optimal dosage and treatment duration and to assess the effects on metabolic indicators in order to develop evidence-based guidelines for effective implementation.

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