2025, Number 07
<< Back Next >>
Med Int Mex 2025; 41 (07)
Factors related with failure of treatment for peritonitis associated with peritoneal dialysis
Cortés MAL, López MJE, López C, Morales SAL, Hernández FS, Ángeles DFB
Language: Spanish
References: 20
Page: 371-377
PDF size: 459.02 Kb.
ABSTRACT
Objective: To identify factors related to treatment failure of peritonitis associated
with peritoneal dialysis.
Materials and Methods: An observational, descriptive, longitudinal, and retrospective
case-control study conducted from January 26, 2022, to January 26, 2023,
included patients with chronic kidney disease and peritonitis receiving peritoneal
dialysis at the Dr. Demetrio Mayoral Pardo General Hospital of Zone 1, Oaxaca de
Juarez, Oaxaca, Mexico. Data were collected by reviewing case and control records
and registries. A case was defined as any patient with treatment failure according to
the definition of the 2022 ISPD guidelines. Controls were patients who did respond
to treatment.
Results: Data were obtained from 123 patients, of which 29 were cases and 94
controls. The variable associated with treatment failure was hypoalbuminemia with
a cut-off value of 2.15 g/dL, p ‹ 0.001, OR 5.57, AUC 0.726 (95% CI: 0.623-0.828).
Conclusions: In patients with chronic kidney disease on peritoneal dialysis who
develop peritonitis, hypoalbuminemia, defined as albumin level ‹ 2.15 g/dL, is associated
with a higher risk of treatment failure.
REFERENCES
Yin S, Tang M, Rao Z, et al. Risk factors and pathogenspectrum in continuous ambulatory peritoneal dialysisassociatedperitonitis: A single center retrospectivestudy. Med Sci Monit 2022; 28: e937112-1. https://doi.org/10.12659/MSM.937112
Hsieh YP, Wang SC, Chang CC, et al. The negative impactof early peritonitis on continuous ambulatory peritonealdialysis patients. Perit Dial Int 2014; 34 (6): 627. https://doi.org/10.3747/pdi.2013.00024
Mujais S. Microbiology and outcomes of peritonitis in NorthAmerica. Kidney Int Suppl 2006; 70 (103). doi: 10.1038/sj.ki.5001916
Fijter CWH, Jakulj L, Amiri F, et al. Intraperitoneal meropenemfor polymicrobial peritoneal dialysis-relatedperitonitis. Perit Dial Int 2016; 36 (5): 572. https://doi.org/10.3747/pdi.2016.00023
Nadeau-Fredette AC, Bargman JM. Characteristics andoutcomes of fungal peritonitis in a modern North Americancohort. 2015; 35 (1): 78-84. https://doi.org/103747/pdi201300179 2015
Li PKT, Chow KM, Cho Y, et al. ISPD peritonitis guidelinerecommendations: 2022 update on prevention and treatment.Periton Dial Int 2022; 42 (2): 110-53. https://doi.org/10.1177/08968608221080586
Chen HL, Tarng DC, Huang LH, Lee EY. Risk factors associatedwith outcomes of peritoneal dialysis in Taiwan: Analysis usinga competing risk model. Medicine 2019; 98 (6). https://doi.org/10.1097/MD.0000000000014385
8iang C, Zheng Q. Outcomes of peritoneal dialysis inelderly vs non-elderly patients: A systemic review andmeta-analysis. PLoS One 2022; 17 (2): e0263534. https://doi.org/10.1371/journal.pone.0263534
He P, Hu JP, Li H, et al. Red blood cell distribution widthand peritoneal dialysis-associated peritonitis prognosis.Ren Fail 2020; 42 (1): 613-21. https://doi.org/10.1080/0886022X.2020.1786401
Wan S, Tian H, Cheng L, et al. Baseline serum triglyceridepredicts early-onset peritonitis and prognosis in incidentCAPD patients. Medicine 2021; 100 (2): e23673. https://doi.org/10.1097/MD.0000000000023673
Huang YJ, Jiang ZP, Zhou JF, et al. Hypertriglyceridemia is arisk factor for treatment failure in patients with peritonealdialysis-related peritonitis. Int Urol Nephrol 2022; 54 (7):1583-9. https://doi.org/10.1007/s11255-021-03027-x
Liu X, Qin A, Zhou H, et al. Novel predictors and riskscore of treatment failure in peritoneal dialysis-relatedperitonitis. Front Med (Lausanne) 2021; 8: 639744.https://doi.org/10.3389/fmed.2021.639744
Diao X, Zheng Z, Yi C, et al. Association of abnormal ironstatus with the occurrence and prognosis of peritonealdialysis-related peritonitis: A longitudinal data-based 10-year retrospective study. Nutrients 2022; 14 (8). https://doi.org/10.3390/nu14081613
Zhao J, Yang L, Zhu X, et al. [Clinical characteristics andtreatment out comes of first peritonitis in patients receivinglong-term peritoneal dialysis: a multicenter study]. NanFang Yi Ke Da XueXue Bao 2020; 40 (12): 1740-6. https://doi.org/10.12122/j.issn.1673-4254.2020.12.07
Chung MC, Yu TM, Wu MJ, et al. Impact of peritonealdialysis-related peritonitis on PD discontinuationand mortality: A population-based national cohortstudy. Perit Dial Int 2022; 42 (2): 194-203. https://doi.org/10.1177/08968608211018949
Zeng Y, Jiang X, Feng S, et al. The influence of seasonalfactors on the incidence of peritoneal dialysis-associatedperitonitis. Ren Fail 2020; 42 (1): 807-17. https://doi.org/10.1080/0886022X.2020.1804401
Hong YA, Kim JH, Kim YK, et al. Low parathyroid hormonelevel predicts infection-related mortality in incidentdialysis patients: a prospective cohort study. Korean JIntern Med 2019; 35 (1): 160-70. https://doi.org/10.3904/kjim.2018.264
Yoshida H, Inaguma D, Koshi-Ito E, et al. Extreme hyperuricemiais a risk factor for infection-related deaths inincident dialysis patients: a multicenter prospective cohortstudy. 2020; 42 (1): 646-55. https://doi.org/10.1080/0886022X.2020.1788582
Htay H, Seng JJ, Yong MH, et al. Comparison of clinicalpresentation and outcomes of peritonitis in the elderly andyounger peritoneal dialysis patients. Perit Dial Int 2019;39 (2): 163-8. https://doi.org/10.3747/pdi.2018.00056
Meng L, Zhu X, Yang L, et al. Development and validationof a prediction model for treatment failure in peritonealdialysis-associated peritonitis patients: a multicenter study.Nan Fang Yi Ke Da Xue Xue Bao 2022; 42 (4): 546-553.https://doi.org/10.12122/j.issn.1673-4254.2022.04.10