Luna-Ortiz P, Soria-Castro E, Soule-Egea M, Gómez-Sánchez M, Martínez-Rosas M, Torrico-Lavayen R

Language: Spanish
References: 19
Page: 225-228
PDF size: 1008.04 Kb.

ABSTRACT

Patients with type 2 diabetes mellitus (T2DM) have a higher incidence of cardiovascular disease, particularly heart failure (HF), as part of diabetic cardiomyopathy (DCM). It is now recognized that disorders in cardiac energy metabolism play a fundamental role in the development of HF from DCM. Mitochondrial dysfunction of cardiomyocytes could explain the pathogenesis of HF present in these patients. There are several experimental studies on alterations in mitochondrial structure and function in various tissues of animal models that explain myocardial functional alterations. However, there are few studies on human subjects. The objective of this work was to study the ultrastructural changes in the mitochondria of the appendages of the right atrium of the heart of diabetic patients undergoing cardiac surgery with extracorporeal circulation. The results show a decrease in the number of mitochondria, as well as their morphology, size, and distribution in samples from patients with T2DM compared to non-diabetics. Although this study demonstrates mitochondrial ultrastructural changes, functional studies are required to demonstrate mitochondrial dysfunction in the diabetic heart.

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