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Revista Mexicana de Anestesiología

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ISSN 0484-7903 (Print)
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2025, Number 4

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Rev Mex Anest 2025; 48 (4)

Semaglutide: a new and serious growing risk

Gaytán-Fernández B
Full text How to cite this article 10.35366/121407

DOI

DOI: 10.35366/121407
URL: https://dx.doi.org/10.35366/121407

Language: Spanish
References: 12
Page: 283-284
PDF size: 333.45 Kb.


Key words:

semaglutide, retardation of gastric emptying, pulmonary aspiration, glucagon-like peptide-1 receptor agonist, general anesthesia, sedation.




REFERENCES

  1. Escobar CS, Castro A, Gómez Cerezo J, Górriz JL, Obaya Rebollar JC, Villar-Taibo R. Abordaje práctico de la semaglutida en el paciente con diabetes tipo 2. Rev Esp Cardiol Supl. 2022;22:1-9.

  2. Badve SV, Bilal A, Lee MMY, Sattar N, Gerstein HC, Ruff CT, et al. Effects of GLP-1 receptor agonists on kidney and cardiovascular disease outcomes: a meta-analysis of randomised controlled trials. Lancet Diabetes Endocrinol. 2025;13:15-28.

  3. Apperloo EM, Gorriz JL, Soler MJ, Cigarrán Guldris S, Cruzado JM, Puchades MJ, et al. Semaglutide in patients with overweight or obesity and chronic kidney disease without diabetes: a randomized double-blind placebo-controlled clinical trial. Nat Med. 2025;31:278-285. doi: 10.1038/s41591-024-03327-6.

  4. Neumann J, Hadová K, Klimas J, Hofmann B, Gergs U. Contractile effects of semaglutide in the human atrium. Pharmaceutics. 2024;16:1139. doi: 10.3390/pharmaceutics16091139.

  5. Fujino E, Cobb KW, Schoenherr J, Gouker L, Lund E. Anesthesia considerations for a patient on semaglutide and delayed gastric emptying. Cureus. 2023;15:e42153. doi: 10.7759/cureus.42153.

  6. Practice Guidelines for Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration: Application to Healthy Patients Undergoing Elective Procedures: An Updated Report by the American Society of Anesthesiologists Task Force on Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration. Anesthesiology. 2017;126:376-393. doi: 10.1097/ALN.0000000000001452.

  7. Klein SR, Hobai IA. Semaglutide, delayed gastric emptying, and intraoperative pulmonary aspiration: a case report. Can J Anaesth. 2023;70:1394-1396. doi: 10.1007/s12630-023-02440-3.

  8. Gulak MA, Murphy P. Regurgitation under anesthesia in a fasted patient prescribed semaglutide for weight loss: a case report. Can J Anaesth. 2023;70:1397-1400. doi: 10.1007/s12630-023-02521-3.

  9. Beam WB, Hunter Guevara LR. Are 1 serious anesthesia risks of semaglutide and other GLP-1 agonists under-recognized? Case reports of retained solid gastric contents in patients undergoing anestheia. APSF Newsletter. 2023;38:67, 69-71.

  10. Fezza R, Rains B, Fezza T, Fezza JP. Emerging anesthesia risks with semaglutide. Plast Reconstr Surg Glob Open. 2023;11:e5427. doi: 10.1097/GOX.0000000000005427.

  11. Angulo Cardoso G, Balverde Camińo E, Irizaga Dávila G, Agonistas Glucagon Like Peptide - 1 (GLP-1) y retraso del vaciamiento gástrico: Consideraciones anestésicas y clínicas. Rev Chil Anest. 2024;53:28-32. doi: 10.25237/revchilanestv53n1-06.

  12. Pai SL, Smith MA, Beam WB, et al. Perioperative considerations for patients on semaglutide. Curr Anesthesiol Rep. 2024;14:152-160. doi: 10.1007/s40140-024-00611-6.




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Rev Mex Anest. 2025;48