medigraphic.com
Órgano Oficial del Colegio Mexicano de Alergia, Asma e Inmunología Pediátrica y de la Asociación Latinoamericana de Pediatría

2025, Number 1

<< Back Next >>

Alerg Asma Inmunol Pediatr 2025; 34 (1)

Correlation of asthma control test with spirometry in patients with mild to moderate asthma

Amador-Gutiérrez K, González-Tuyub Y, Nava-Ramírez IC, González-Luna RH, Azamar-Jácome AA

Language: Spanish
References: 24
Page: 6-11
PDF size: 379.14 Kb.


ABSTRACT

Introduction: asthma is a chronic inflammatory disease of the airways. The diagnosis typically involves a combination of symptoms, lung function tests and therapeutic response. Asthma's varied progression, or heterogeneity, requires continuous monitoring using a combination of objective and subjective tools to assess lung function and patient experience. Objective: to assess if there is a linear correlation between the score in the Asthma Control Test (ACT) and the degree of obstruction measured by FEV1 from spirometry in patients with mild to moderate asthma. Material and methods: observational, analytical, cross-sectional, prospective study. Data from ACT and FEV1 were collected from patients over 18 years old with a diagnosis of mild to moderate asthma, attending a third-level hospital in Mexico. Results: a total of 60 patients were analyzed (78.3% women, 21.7% men), with a mean age of 51.6 ± 13.53 years (median age 51.5 years, minimum 18 years, and maximum 82 years). Median ACT scores was 21 points (minimum 11, maximum 25 points), and median FEV1 percentage was 88.5% (minimum 56%, maximum 121%). When analyzing the correlation between FEV1 and ACT values, an inverse correlation (r = –0.115) was found in the qualitative analysis of the variables, and a weak correlation (r = 0.017) was found in the quantitative analysis. Conclusions: the ACT is an affordable and easily accessible tool for monitoring asthma patients. However, due to the lack of a significant correlation with objective values, it cannot be recommended as the sole evaluation tool.


REFERENCES

  1. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2023. Updated July 2023. Available in: www.ginasthma.org

  2. Tarasidis GS, Wilson KF. Diagnosis of asthma: clinical assessment. Int Forum Allergy Rhinol [Internet]. 2015; 5 (S1). Available in: http://dx.doi.org/10.1002/alr.21518

  3. Zhou J, Yi F, Wu F, Xu P, Chen M, Shen H et al. Characteristics of different asthma phenotypes associated with cough: a prospective, multicenter survey in China. Respir Res [Internet]. 2022; 23 (1). Available in: http://dx.doi.org/10.1186/s12931-022-02104-8

  4. Moral Gil L, Asensio de la Cruz O, Lozano Blasco J. ASMA: aspectos clínicos y diagnósticos. Protoc Diagn Ter Pediatr. 2019; 2: 103-115.

  5. Papakosta D, Latsios D, Manika K, Porpodis K, Kontakioti E, Gioulekas D. Asthma control test is correlated to FEV1 and nitric oxide in Greek asthmatic patients: influence of treatment. J Asthma [Internet]. 2011; 48 (9): 901-906. Available in: http://dx.doi.org/10.3109/02770903.2011.611958

  6. Armeftis C, Gratziou C, Siafakas N, Katsaounou P, Pana ZD, Bakakos P. An update on asthma diagnosis. J Asthma [Internet]. 2023; 60 (12): 2104-2110. Available in: http://dx.doi.org/10.1080/02770903.2023.2228911

  7. Larenas-Linnemann D, Gochicoa-Rangel L, Macías-Weinmann A, Soto-Ramos M, Luna-Pech JA, Elizondo-Ríos A et al. Consenso mexicano en relación con la fracción exhalada de óxido nítrico (FeNO) en asma 2020. Rev Alerg Mex [Internet]. 2020; 67 Suppl 2: S1-25. Disponible en: http://dx.doi.org/10.29262/ram.v67i0.760

  8. Dirección General de Epidemiología (DGEPI). Anuario de morbilidad 1984-2022 [Internet]. 2022. Disponible en: https://epidemiologia.salud.gob.mx/anuario/html/index.html

  9. Gans MD, Gavrilova T. Understanding the immunology of asthma: pathophysiology, biomarkers, and treatments for asthma endotypes. Paediatr Respir Rev [Internet]. 2020; 36: 118-127. Available in: http://dx.doi.org/10.1016/j.prrv.2019.08.002

  10. Nguyen VN, Chavannes NH. Correlation between fractional exhaled nitric oxide and Asthma Control Test score and spirometry parameters in on-treatment- asthmatics in Ho Chi Minh City. J Thorac Dis [Internet]. 2020; 12 (5): 2197-2209. Available in: http://dx.doi.org/10.21037/jtd.2020.04.01

  11. Nawaz SF, Ravindran M, Kuruvilla ME. Asthma diagnosis using patient-reported outcome measures and objective diagnostic tests: now and into the future. Curr Opin Pulm Med [Internet]. 2022; 28 (3): 251-257. Available in: http://dx.doi.org/10.1097/mcp.0000000000000871

  12. Stanojevic S, Kaminsky DA, Miller MR, Thompson B, Aliverti A, Barjaktarevic I et al. ERS/ATS technical standard on interpretive strategies for routine lung function tests. Eur Respir J [Internet]. 2022; 60 (1): 2101499. Available in: http://dx.doi.org/10.1183/13993003.01499-2021

  13. Wojtczak HA, Wachter AM, Lee M, Burns L, Yusin JS. Understanding the relationship among pharmacoadherence measures, asthma control test scores, and office-based spirometry. Ann Allergy Asthma Immunol [Internet]. 2012; 109 (2): 103-107. Available in: http://dx.doi.org/10.1016/j.anai.2012.05.018

  14. Álvarez-Gutiérrez FJ, Medina-Gallardo JF, Pérez-Navarro P, Martín-Villasclaras JJ, Martin Etchegoren B, Romero-Romero B et al. Relación del test de control del asma (ACT) con la función pulmonar, niveles de óxido nítrico exhalado y grados de control según la Iniciativa Global para el Asma (GINA). Arch Bronconeumol [Internet]. 2010; 46 (7): 370-377. Disponible en: http://dx.doi.org/10.1016/j.arbres.2010.04.003

  15. Melosini L, Dente FL, Bacci E, Bartoli ML, Cianchetti S, Costa F et al. Asthma control test (ACT): comparison with clinical, functional, and biological markers of asthma control. J Asthma [Internet]. 2012; 49 (3): 317-323. Available in: http://dx.doi.org/10.3109/02770903.2012.6610084

  16. Yangui F, Ayari R, Abouda M, Charfi MR. The relationship between the fraction of exhaled nitric oxide and the level of asthma control. Tunis Med. 2019; 97 (7): 891-897.

  17. Ito Y, Adachi Y, Itazawa T, Okabe Y, Adachi YS, Higuchi O et al. Association between the results of the childhood asthma control test and objective parameters in asthmatic children. J Asthma [Internet]. 2011; 48 (10): 1076-1080. Available in: http://dx.doi.org/10.3109/02770903.2011.629356

  18. Dirección General de Epidemiología (DGEPI). Incidencia de asma (J45, J46) por grupos de edad [Internet]. 2022. Disponible en: https://epidemiologia.salud.gob.mx/anuario/2022/incidencia/incidencia_casos_nuevos_enfermedad_grupo_edad.pdf

  19. Chowdhury NU, Guntur VP, Newcomb DC, Wechsler ME. Sex and gender in asthma. Eur Respir Rev [Internet]. 2021; 30 (162): 210067. Available in: http://dx.doi.org/10.1183/16000617.0067-2021

  20. Grant T, Croce E, Matsui EC. Asthma and the social determinants of health. Ann Allergy Asthma Immunol [Internet]. 2022; 128 (1): 5-11. Available in: http://dx.doi.org/10.1016/j.anai.2021.10.002

  21. Cazzola M, Rogliani P, Ora J, Calzetta L, Matera MG. Asthma and comorbidities: recent advances. Pol Arch Med Wewn [Internet]. 2022; 132 (4). Available in: http://dx.doi.org/10.20452/pamw.16250

  22. Nathan RA, Sorkness CA, Kosinski M, Schatz M, Li JT, Marcus P et al. Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol [Internet]. 2004; 113 (1): 59-65. Available in: http://dx.doi.org/10.1016/j.jaci.2003.09.008

  23. Nelsen LM, Kosinski M, Rizio AA, Jacques L, Schatz M, Stanford RH et al. A structured review evaluating content validity of the Asthma Control Test, and its consistency with U.S. guidelines and patient expectations for asthma control. J Asthma [Internet]. 2022; 59 (3): 628-637. Available in: http://dx.doi.org/10.1080/02770903.2020.1861624

  24. Shirai T, Furuhashi K, Suda T, Chida K. Relationship of the asthma control test with pulmonary function and exhaled nitric oxide. Ann Allergy Asthma Immunol [Internet]. 2008; 101 (6): 608-613. Available in: http://dx.doi.org/10.1016/S1081-1206(10)60223-2




2020     |     www.medigraphic.com