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Ginecología y Obstetricia de México

Federación Mexicana de Ginecología y Obstetricia, A.C.
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2025, Number 8

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Ginecol Obstet Mex 2025; 93 (8)

Impact of the age of the recipient on the pregnancy rate in egg donation cycles

González GEL, Robellada ZCM, Carballo ME, Kably AA
Full text How to cite this article

Language: Spanish
References: 9
Page: 295-299
PDF size: 186.18 Kb.


Key words:

In vitro fertilization, Embryo transfers, Middle aged, Egg donation, Pregnancy rate, Progesterone.

ABSTRACT

Objective: To determine whether a woman's age affects the pregnancy rate in oocyte recipients.
Methods and Materials: This retrospective, observational, descriptive study was conducted on patients who underwent in vitro fertilization and egg donation cycles at the Dr. Alberto Kably Mexican Fertility Center between 2005 and 2022. A p-value of less than 0.05 was considered statistically significant, and statistical analysis was performed using SPSS software.
Results: A total of 743 patients were studied and divided into five groups based on age: under 30, 31 to 35, 36 to 40, 41 to 45, and over 45 years old. The largest group was 40 to 44 years old (42.8%). The pregnancy rate was higher in the under-30 group than in those over 45 (p = 0.02). The highest miscarriage rate was recorded in patients over 45 years of age, with a more pronounced trend compared to patients under 30 and aged 40 to 44 (p = 0.001). Regarding endometrial thickness, a decrease in the pregnancy rate was observed when embryo transfers were performed with an endometrial thickness of 6 mm or less or 15 mm or more before progesterone administration.
Conclusion: These results are consistent with previous studies that reported a significant difference in pregnancy rates related to the age of oocyte recipients.


REFERENCES

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  2. Cimadomo D, Fabozzi G, Vaiarelli A, Ubaldi N, et al. Impactof maternal age on oocyte and embryo competence.Front Endocrinol 2018; 9. https://doi.org/10.3389/fendo.2018.00327

  3. Berntsen S, Larsen EC, la Cour Freiesleben N, Pinborg A.Pregnancy outcomes following oocyte donation. Best PractRes Clin Obstet Gynaecol 2021; 70: 81-91. https://doi.org/10.1016/j.bpobgyn.2020.07.008

  4. Bu Z, Sun Y. The impact of endometrial thickness on theday of human chorionic gonadotrophin (hCG) administrationon ongoing pregnancy rate in patients with differentovarian response. PLoS One 2015; 10 (12). https://doi.org/10.1371/journal.pone.0145703

  5. Toner JP, Grainger DA, Frazier LM. Clinical outcomes amongrecipients of donated eggs: an analysis of the US nationalexperience, 1996-1998. Fertility and Sterility 2002; 78 (5):1038-54. https://doi.org/10.1016/S0015-0282(02)03371-X

  6. Yeh JS, Steward RG, Dude AM, Shah AA, et al. Pregnancyoutcomes decline in recipients over age 44: An analysis of27,959 fresh donor oocyte in vitro fertilization cycles fromthe Society for Assisted Reproductive Technology. FertilSteril 2014; 101 (5): 1331-36. https://doi.org/10.1016/j.fertnstert.2014.01.056

  7. Liu KE, Hartman M, Hartman A, Luo ZC, et al. The impactof a thin endometrial lining on fresh and frozen-thaw IVFoutcomes: An analysis of over 40 000 embryo transfers.Human Reproduction 2018; 33 (10): 1883-88. https://doi.org/10.1093/humrep/dey281

  8. Haas J, Smith R, Zilberberg E, Nayot D, et al. Endometrialcompaction (decreased thickness) in response toprogesterone results in optimal pregnancy outcomein frozen-thawed embryo transfers. Fertil Steril 2019;112 (3): 503-509.e1. https://doi.org/10.1016/j.fertnstert.2019.05.001

  9. Marcus Y, Segev E, Shefer G, Sack J, et al. Multidisciplinarytreatment of the metabolic syndrome lowers blood pressurevariability independent of blood pressure control. J Clin Hypertens2016; 18 (1): 19-24. https://doi.org/10.1111/jch.12685




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Ginecol Obstet Mex. 2025;93