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2025, Number 1

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Sal Jal 2025; 12 (1)

Asymptomatic biliary pseudolithiasis secondary the use of parenteral ceftriaxone: case report

Reyes-Hernández MU, Reyes-Hernández KL, Reyes-Gómez U, López-Cruz G, Quero-Hernández A, Ayuzo-del VNC, Royzman-Rivera L, Caballero NB, Flores-Osorio X, Aguilar-Figueroa S, Celio MR, Balderas-Cacho X
Full text How to cite this article 10.35366/121776

DOI

DOI: 10.35366/121776
URL: https://dx.doi.org/10.35366/121776

Language: Spanish
References: 7
Page: 34-37
PDF size: 695.10 Kb.


Key words:

ceftriaxone, child, adverse effect, gallbladder pseudolithiasis, ultrasound.

ABSTRACT

Introduction: drug reactions are relatively common in pediatrics. Ceftriaxone, a third-generation cephalosporin used to treat severe infections, can cause various adverse reactions, including the formation of biliary pseudolithiasis. This study aims to present a clinical case and highlight the importance of early diagnosis and appropriate follow-up of this complication. Case report: a one-year-four-month-old male infant presented with a fever and oral refusal, receiving ceftriaxone for bacteremia secondary to a severe urinary tract infection. An abdominal ultrasound performed 48 hours after starting treatment showed biliary pseudolithiasis, leading to a change in therapy. Conclusion: biliary pseudolithiasis secondary to ceftriaxone is a significant complication in pediatric practice that can present with a variety of gastrointestinal symptoms. Early diagnosis, based on characteristic ultrasound findings, and appropriate management are essential to avoid unnecessary complications and improve clinical outcomes in these patients.


REFERENCES

  1. National Center for Biotechnology Information. Compound Summary for Ceftriaxone. PubChem 2024.

  2. Bor O, Dinleyici EC, Kebapci M, Aydogdu SD. Ceftriaxone-associated biliary sludge and pseudocholelithiasis during childhood: a prospective study. Pediatr Int. 2004;46(3):322-324. Available in: https://doi.org/10.1111/j.1328-0867.2004.01884.x

  3. Zeng L, Wang C, Jiang M, Chen K, Zhong H, Chen Z, et al. Safety of ceftriaxone in paediatrics: a systematic review. Arch Dis Child. 2020;105(10):981-985. Available in: https://doi.org/10.1136/archdischild-2019-317950

  4. Palanduz A, Yalcin I, Tonguc E, Güler N, Ones U, Salman N, et al. Sonographic assessment of ceftriaxone-associated biliary pseudolithiasis in children. J Clin Ultrasound. 2000;28(4):166-168. Available in: https://doi.org/10.1002/(SICI)1097-0096(200005)28:4<166::AID-JCU2>3.0.CO;2-G

  5. Prince JS, Senac MO Jr. Ceftriaxone-associated nephrolithiasis and biliary pseudolithiasis in a child. Pediatr Radiol. 2003;33(9):648-651. Available in: https://doi.org/10.1007/s00247-003-0963-0

  6. Rodríguez RDA, Pinilla OAP, Bustacara DM, Henao GL, López CA, Montoya CR, et al. Cálculos biliares asociados al uso de ceftriaxona en niños. Anales de Pediatría. 2014;80:77-80.

  7. Reyes-Hernández DP, Reyes-Hernández U, Reyes-Gómez U, Toledo-Ramírez MI, Reyes-Hernández KL, Cruz-García L, et al. Two cases ceftriaxone-associated biliary pseudolithiasis in children. Rev Mex Pediatr. 2012;79(5):236-239.




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Sal Jal. 2025;12