Calderón SJV, Camacho CR

Language: Spanish
References: 18
Page: 144-149
PDF size: 287.72 Kb.

ABSTRACT

The microbiota is made up of the symbiosis with the body of bacteria, fungi, parasites and viruses, in coexistence in the form of mutualism or commensal people, which affects, positively or negatively, the physiology of the organism. The effects of the microbiota can be local or systemic and can be immunological, endocrine, neurological, and inflammatory. Amazingly, the metabolism of the microbiota or its presence in the gut can affect the production of cytokines, chemokines, and hormones that affect neurological systems. The effects of the gut microbiota on the central nervous system open the possibility of understanding various diseases, their neurophysiological aspects and the possible adjuvant treatment with prebiotics and probiotics in diseases as complex as anxiety.

REFERENCES

1. Sender R, Fuchs S, Milo R: Revised Estimatesfor the Number of Human and Bacteria Cells in theBody. PLoS Biol 2016, 14(8):e1002533.

2. Jang HM, Lee HJ, Jang SE, Han MJ, Kim DH:Evidence for interplay among antibacterial-inducedgut microbiota disturbance, neuro-inflammation,and anxiety in mice. Mucosal Immunol 2018,11(5):1386-1397.

3. Simpson CA, Diaz-Arteche C, Eliby D, SchwartzOS, Simmons JG, Cowan CSM: The gut microbiotain anxiety and depression - A systematic review.Clin Psychol Rev 2021, 83:101943.

4. Jang HM, Lee KE, Lee HJ, Kim DH:Immobilization stress-induced Escherichia colicauses anxiety by inducing NF-κB activationthrough gut microbiota disturbance. Sci Rep 2018, 8(1):13897.

5. McGaughey KD, Yilmaz-Swenson T, ElsayedNM, Cruz DA, Rodriguiz RM, Kritzer MD,Peterchev AV, Roach J, Wetsel WC, Williamson DE:Relative abundance of Akkermansia spp. and otherbacterial phylotypes correlates with anxiety- anddepressive-like behavior following social defeat inmice. Sci Rep 2019, 9(1):3281.

6. Chen YH, Bai J, Wu D, Yu SF, Qiang XL, Bai H,Wang HN, Peng ZW: Association between fecalmicrobiota and generalized anxiety disorder:Severity and early treatment response. J AffectDisord 2019, 259:56-66.

7. Kouraki A, Kelly A, Vijay A, Gohir S, Astbury S,Georgopoulos V, Millar B, Walsh DA, Ferguson E,Menni C et al: Reproducible microbiomecomposition signatures of anxiety and depressivesymptoms. Comput Struct Biotechnol J 2023,21:5326-5336.

8. Guo Y, Xie JP, Deng K, Li X, Yuan Y, Xuan Q,Xie J, He XM, Wang Q, Li JJ et al: ProphylacticEffects of. Front Behav Neurosci 2019, 13:126.

9. Nikel K, Stojko M, Smolarczyk J, Piegza M: TheImpact of Gut Microbiota on the Development ofAnxiety Symptoms-A Narrative Review. Nutrients2025, 17(6).

10. Pan M, Qian C, Huo S, Wu Y, Zhao X, YingY, Wang B, Yang H, Yeerken A, Wang T et al: Gut-derived lactic acid enhances tryptophan to 5-hydroxytryptamine in regulation of anxiety via. GutMicrobes 2025, 17(1):2447834.

11. Zhu J, Qi R, Liu Y, Zhao L, Han W:Mechanistic Insights into the Effect of Ligands onStructural Stability and Selectivity ofSulfotransferase 2A1 (SULT2A1). ACS Omega2019, 4(26):22021-22034.

12. Cao Y, Cheng Y, Pan W, Diao J, Sun L, MengM: Gut microbiota variations in depression andanxiety: a systematic review. BMC Psychiatry 2025,25(1):443.

13. Duranti S, Ruiz L, Lugli GA, Tames H, MilaniC, Mancabelli L, Mancino W, Longhi G, CarnevaliL, Sgoifo A et al: Bifidobacterium adolescentis as akey member of the human gut microbiota in theproduction of GABA. Sci Rep 2020, 10(1):14112.

14. Ma T, Jin H, Kwok LY, Sun Z, Liong MT,Zhang H: Probiotic consumption relieved humanstress and anxiety symptoms possibly viamodulating the neuroactive potential of the gutmicrobiota. Neurobiol Stress 2021, 14:100294.

15. Zhao Z, Xiao G, Xia J, Guo H, Yang X, JiangQ, Wang H, Hu J, Zhang C: Effectiveness ofprobiotic/prebiotic/synbiotic treatments on anxiety:A systematic review and meta-analysis ofrandomized controlled trials. J Affect Disord 2023,343:9-21.

16. Xu MM, Qiu WH, Ma QY, Yu ZY, Yang WM,Hu TN, Guo Y, Chen XY: Improving precisionmanagement of anxiety disorders: a Mendelianrandomization study targeting specific gutmicrobiota and associated metabolites. FrontMicrobiol 2024, 15:1380912.

17. Hills RD, Pontefract BA, Mishcon HR, BlackCA, Sutton SC, Theberge CR: Gut Microbiome:Profound Implications for Diet and Disease.Nutrients 2019, 11(7).

18. Yang Q, Liang Q, Balakrishnan B,Belobrajdic DP, Feng QJ, Zhang W: Role of DietaryNutrients in the Modulation of Gut Microbiota: ANarrative Review. Nutrients 2020, 12(2).