Gómez-García CA, Sánchez-Naranjo AG, Ojeda GA, García Álvarez D, Romero-Martínez BS, Flores-Soto E

Language: Spanish
References: 21
Page: 54-65
PDF size: 322.87 Kb.

ABSTRACT

Objective. To evaluate the relationship between hyperinsulinism and binge eating disorder (BED) in patients with obesity treated at the Naval Specialties Hospital of Veracruz. Materials and methods. An observational, cross-sectional, and analytical study was conducted, with a non-probabilistic sampling of patients between 18 and 65 years of age with a BMI ›25 kg/m^², during the period from August 2023 to May 2024. The Binge Eating Scale (BES) was applied and variables such as glycated hemoglobin and HOMA-IR were analyzed using descriptive and inferential statistics with SPSS v26. Results. A total of 411 patients (163 men and 248 women) were included, with a mean age of 42 ± 11 years. BED was identified in 49% of the participants, with a higher prevalence in women (p = 0.000). The type of obesity was significantly associated with BED, with obesity type I and obesity grade II predominating in those who presented the disorder (p=0.000). Hyperinsulinemia was detected in 25% of the sample, being more frequent in men (p=0.0019). A significant statistical difference was found between the group with BED and the presence of hyperinsulinism (t=7.7, p=0.0000), with an odds ratio (OR=7.7, 95% CI 4.4–13.5), indicating that BED increases the risk of hyperinsulinism 7.7-fold. Conclusion. BED was the most prevalent eating disorder in this population with obesity, and a relationship was established between the presence of this disorder and hyperinsulinism. These findings demonstrate the need for a comprehensive approach that considers both metabolic and psychological factors for effective treatment of obesity.

REFERENCES

1. GPC. Diagnóstico y Tratamiento del Sobrepesoy Obesidad Exogena. IMSS 2018.

2. Gaskin CJ, Cooper K, Stephens LD, PeetersA, Salmon J, Porter J. Clinical practiceguidelines for the management of overweightand obesity published internationally:A scoping review. Obes Rev 2024; 25(5).doi:10.1111/obr.13700.

3. Barquera S, Rivera JA. Obesity in Mexico:rapid epidemiological transition and food industryinterference in health policies. LancetDiabetes Endocrinol 2020; 8(9):746-747.doi:10.1016/s2213-8587(20)30269-2.

4. Cornier MA. A review of current guidelinesfor the treatment of obesity. Am J ManagCare 2022; 28(Suppl 15):S288-S296.doi:10.37765/ajmc.2022.89292.

5. Templeman NM, Skovsø S, Page MM, LimGE, Johnson JD. A causal role for hyperinsulinemiain obesity. J Endocrinol 2017;232(3):R173-R183. doi:10.1530/joe-16-0449.

6. Janssen JAMJL. Hyperinsulinemia and ItsPivotal Role in Aging, Obesity, Type 2 Diabetes,Cardiovascular Disease and Cancer.Int J Mol Sci 2021; 22(15):7797.doi:10.3390/ijms22157797

7. Asociación Americana de Psiquiatría. ManualDiagnóstico y Estadístico de los TrastornosMentales. 5a. Ed. CDMX: EditorialMedica Panamericana; 2013.

8. Agüera Z, Lozano-Madrid M, Mallorquí-BaguéN, Jiménez-Murcia S, Menchón JM, Fernández-Aranda F. A review of binge eatingdisorder and obesity. Neuropsychiatr 2021;35(2):57-67. doi:10.1007/s40211-020-00346-w.

9. Bulik CM, Sullivan PF, Kendler KS. Medicaland psychiatric morbidity in obese womenwith and without binge eating. Int J Eat Disord2002; 32(1):72-8. doi:

10. 10.1002/eat.10072.10. Kessler RC, Berglund PA, Chiu WT, DeitzAC, Hudson JI, Shahly V, et al. The Prevalenceand Correlates of Binge Eating Disorderin the World Health Organization WorldMental Health Surveys. Biol Psychiatry2013; 73(9):904-914. doi:10.1016/j.biopsych.2012.11.020.

11. Peterson CB, Swanson SA, Crow SJ, MitchellJE, Agras WS, Halmi KA, et al. Longitudinalstability of binge􀇦eating type in eating disorders.Int J Eat Disord 2012; 45(5):664-669.doi:10.1002/eat.22008.

12. Ilyas A, Hübel C, Stahl D, Stadler M, IsmailK, Breen G, et al. The metabolic underpinningof eating disorders: A systematic reviewand meta-analysis of insulin sensitivity. MolCell Endocrinol 2019; 497:110307.doi:10.1016/j.mce.2018.10.005.

13. Giel KE, Bulik CM, Fernandez-Aranda F,Hay P, Keski-Rahkonen A, Schag K, et al.Binge eating disorder. Nat Rev Dis Primers2022; 8(1): 16. doi:10.1038/s41572-022-00344-y.

14. Franco K, Alvarez GL, Ramírez RE. Instrumentospara trastornos del comportamientoalimentario validados en mujeres mexicanas:Una revisión de la literatura. Rev Mextrastor aliment 2011; 2(2):148-164.

15. Carrasco F, Galgani JE, Reyes M. Síndromede resistencia a la insulina. estudio ymanejo. Rev Med Clin Condes 2013; 24(5)827-837. DOI: 10.1016/S0716-8640(13)70230-X.

16. Nowak MM, Niemczyk M, Gołębiewski S,Pączek L. Impact of Body Mass Index on All-Cause Mortality in Adults: A Systematic Reviewand Meta-Analysis. J Clin Med 2024;13(8):2305. doi:10.3390/jcm13082305.

17. Bhaskaran K, Dos-Santos-Silva I, Leon DA,Douglas IJ, Smeeth L. Association of BMIwith overall and cause-specific mortality: apopulation-based cohort study of 3·6 millionadults in the UK. Lancet Diabetes Endocrinol2018; 6(12):944-953. doi: 10.1016/S2213-8587(18)30288-2.

18. Arner P, Viguerie N, Massier L, Rydén M,Astrup A, Blaak E, et al. Sex differences inadipose insulin resistance are linked to obesity,lipolysis and insulin receptor substrate1. Int J Obes 2024; 48(7):934-940.doi:10.1038/s41366-024-01501-x.

19. Mikhail ME, Anaya C, Culbert KM, Sisk CL,Johnson A, Klump KL. Gonadal Hormone Influenceson Sex Differences in Binge EatingAcross Development. Curr Psychiatry Rep

20. 2021; 23(11):74. doi: 10.1007/s11920-021-01287-z.20. Kummer KK, Pope HG, Hudson JI, KemmlerG, Pinggera G-M, Mangweth-Matzek B. Agingmale symptomatology and eating behavior.Aging Male 2019; 22(1):55-61.doi:10.1080/13685538.2018.1477931.

21. Mccuen􀇦Wurst C, Ruggieri M, Allison KC.Disordered eating and obesity: associationsbetween binge􀇦eating disorder, night􀇦eatingsyndrome, and weight􀇦related comorbidities.Ann N Acad Sci 2018; 1411(1):96-105.doi:10.1111/nyas.13467.