Medina LJL

Language: Spanish
References: 20
Page: 242-253
PDF size: 954.81 Kb.

ABSTRACT

Introduction: sepsis is a clinical syndrome characterized by a dysregulated immune response to infection, often resulting in organ dysfunction. Despite advances in intensive care, mortality rates remain high, and the molecular mechanisms are not fully understood. Objective: to examine current knowledge on epigenetic mechanisms involved in the pathogenesis and progression of sepsis. Material and methods: a comprehensive literature review was conducted on studies published in the last decade, focusing on key epigenetic regulators such as DNA methylation, histone modifications, and non-coding RNAs and their role in modulating immune responses in sepsis. Results: epigenetic modifications influence the transcriptional control of genes involved in inflammation, immune tolerance, and cellular metabolism during sepsis. Altered epigenetic states contribute to the transition from hyperinflammation to immunosuppression, with emerging evidence suggesting their potential as biomarkers and therapeutic targets. Conclusions: epigenetic regulation represents an important aspect of the pathophysiology of sepsis. Understanding these mechanisms may lead to novel diagnostic strategies and personalized therapeutic interventions.

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