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2026, Number 1

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Aten Fam 2026; 33 (1)

Relationship Between Generalized Anxiety Disorder and Irritable Bowel Syndrome

Bucio-Quintero PM, Martínez-Piñón AI, Pérez-Flores LM
Full text How to cite this article

Language: Spanish
References: 24
Page: 9-14
PDF size: 151.97 Kb.


Key words:

Generalized Anxiety Disorder (GAD), Irritable Bowel Syndrome (IBS), Mental Health.

ABSTRACT

Objective: To analyze the relationship between generalized anxiety disorder (GAD) and irritable bowel syndrome (IBS). Methods: A descriptive cross-sectional study with proportional stratified sampling was conducted in 363 patients with GAD from the Mexican Institute of Social Security referred to General Hospital No. 1, in Michoacán between November 2023 and May 2024. The GAD-7 questionnaire was used to assess the severity of anxiety, and a targeted questionnaire based on Rome IV criteria was used to determine the presence of IBS. The association between anxiety severity and the presence of IBS was analyzed using the χ2 Test, with statistical significance set at p‹0.05. Results: The predominant demographic variables were female sex, age 19–29 years, bachelor’s degree education, and married marital status. The overall prevalence of IBS was 51.8% (n= 188). The proportion of IBS was significantly higher in patients with severe anxiety (76.6%) compared to those with mild anxiety (14.3%). A statistically significant association was found between GAD severity and the presence of IBS (p‹0.001). Conclusion: The significant association between increased GAD severity and the presence of IBS justifies systematic gastrointestinal evaluation to optimize interdisciplinary management.


REFERENCES

  1. Javaid SF, Hashim IJ, Hashim MJ, Stip E, SamadMA, Ahbabi AA. Epidemiology of anxiety disorders:global burden and sociodemographic associations.Middle East Curr Psychiatr. 2023;30:44.

  2. Organización Mundial de la Salud. Depresióny otros trastornos mentales comunes. Estimacionessanitarias mundiales. [Internet]. [Citado2025 Oct 14]. Disponible en: https://iris.paho.org/bitstream/handle/10665.2/34006/PAHONMH17005-spa.pdf

  3. Comisión Nacional de Salud Mental y Adicciones.Una mirada a la atención en salud mental en México:principales condiciones atendidas en el Sistemade Salud [Internet]. [Citado 2025 Oct 14]. Disponibleen: https://www.gob.mx/cms/uploads/attachment/file/949747/04_DATOS_SM_2024.pdf

  4. Sebastián-Domingo JJ. Irritable bowel syndrome.Med Clin (Barc). 2022;158(2):76-81.

  5. Breen‑Lyles M, Decuir M, Byale A, Smith K, GroverM. Impact of Rome IV criteria on the prevalenceof post‑infection irritable bowel syndrome. NeurogastroenterolMotil. 2023;35(5):e14532.

  6. Staudacher HM, Black CJ, Teasdale SB, Mikocka‑WalusA, Keefer L. Irritable bowel syndromeand mental health comorbidity – approach to multidisciplinarymanagement. Nat Rev GastroenterolHepatol. 2023;20(9):582–596.

  7. Ramírez AJM, Martínez GCM, Fuentes RMM,Escobedo RMR, Delgado CFR. Agregación familiaren el síndrome de colon irritable en pacientesmexicanos. Un estudio de casos y controles. AtenPrimaria. 2024;56(2):102794.

  8. Lin W, Zhou Y, Liu Y, Liu C, Lin M, Tang Y, et al.Dorsoventral hippocampus distinctly modulatesvisceral sensitivity and anxiety behaviors in maleIBS‑like rats. J Neurosci Res. 2024;102(1):e25289.

  9. Ancona A, Petito C, Iavarone I, Petito V, GalassoL, Leonetti A, et al. The gut–brain axis in irritablebowel syndrome and inflammatory bowel disease.Dig Liver Dis. 2021;53(3):298–305.

  10. Huang XJ, Ma HY, Wang XM, Zhong J, ShengDF, Xu MZ. Equating the PHQ-9 and GAD-7to the HADS depression and anxiety subscales inpatients with major depressive disorder. J of AffectDisord. 2022;311:327-335.

  11. Porto MF, Ocampo-Barba N, Flores-Valdivia G,Caldichoury N, López N. Psychometric propertiesof the GAD‑7 score to detect generalized anxietyin health professionals in Bolivia. Rev Peru MedExp Salud Publica. 2022;39(1):115–116.

  12. González-González A, Sánchez HME, LagunaCJF, Betancourt OD. Evaluación psicométrica dela Escala Atenas de Insomnio en Adultos y AdultosMayores de México.. Psykhe. 2024;33(2):1–13.

  13. Vera González EE. Asociación de ansiedad y/o depresióncon la presencia de síndrome de intestinoirritable en adultos de 20 a 59 años, de la Unidadde Medicina Familiar No. 75 IMSS en el año 2019[Internet]. [citado 2025 Jun 19]. Disponible en:https://repositorio.unam.mx/contenidos/3586689

  14. Pozos‑Radillo BE, Preciado‑Serrano ML, Plascencia‑CamposAR, Morales‑Fernández A, Valdez‑LópezRM, Acosta-Fernández M. Predictive study ofthe psychophysiological symptoms of chronic stressand their association with the irritable bowel syndromein medical students at a public university inMexico. Universitas Psychologica. 2024;23:1–11.

  15. Fadgyas‑Stanculete M, Buga AM, Popa‑WagnerA, Dumitrascu DL. The relationship between irritablebowel syndrome and psychiatric disorders:from molecular changes to clinical manifestations.J Mol Psychiatry. 2014;2(1):4.

  16. Labus JS, Hollister EB, Jacobs J, Kirbach K,Oezguen N, Gupta A, et al. Differences in gut microbialcomposition correlate with regional brainvolumes in irritable bowel syndrome. Microbiome.2017;5(1):49.

  17. Solmi M, Radua J, Olivola M, Croce E, SoardoL, Salazar de Pablo G, et al. Age at onset of mentaldisorders worldwide: large‑scale meta‑analysisof 192 epidemiological studies. Mol Psychiatry.2022;27(1):281–295.

  18. Algera JP, Blomsten A, Khadija M, Verbeke K,Vanuytsel T, Tack J, et al. Distinct age-relatedcharacteristics in patients with irritable bowel syndrome:patient reported outcomes and measures ofgut physiology. npj Gut Liver. 2024;1(10):1-11.

  19. Kim YS, Kim N. Sex‑gender differences in irritablebowel syndrome. J Neurogastroenterol Motil.

  20. 2018;24(4):544–558.20. Farhane-Medina NZ, Luque B, Tabernero C,Castillo-Mayén R. Factors associated with genderand sex differences in anxiety prevalenceand comorbidity: A systematic review. Sci Prog.2022;105(4):368504221135469.

  21. Heamid S, Ibrahim D. Prevalence and interrelationof irritable bowel syndrome with generalized anxietydisorder among Sudanese medical students,2020. BJPsych Open. 2024;10(Supp 1):S46.

  22. Abdelaziz HA, Ellakany WI, Ellakany A, DeanYE, Rouzan SS, Bamousa BAA, et al. The relationshipbetween anxiety and irritable bowelsyndrome symptoms among females: a crosssectionalstudy in Egypt. Medicine (Baltimore).2023;102(32):e34777.

  23. Saroj A, Tripathi A, Rungta S, Kar SK. Psychiatricco‑morbidities and profile of patients with irritablebowel syndrome in Northern India. Brain Sci.2024;14(4):393.

  24. Duffy M, Boggiano VL, Ganesh R, Mueller M.Functional gastrointestinal disorders. Prim Care.2023;




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Aten Fam. 2026;33