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2025, Number 4

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Med Crit 2025; 39 (4)

No reflow phenomenon: report of case

Espinosa CDA, Reyes DI, Gutiérrez MSY, Almaraz RA, Ojeda RC, Zaga CNE
Full text How to cite this article 10.35366/122460

DOI

DOI: 10.35366/122460
URL: https://dx.doi.org/10.35366/122460

Language: Spanish
References: 19
Page: 284-292
PDF size: 1659.59 Kb.


Key words:

non-reflux phenomenon, acute myocardial infarction, catheterization.

ABSTRACT

Introduction: ST-segment elevation myocardial infarction (STEMI) is one of the leading causes of death in Mexico and worldwide. Percutaneous coronary intervention is the treatment of choice to achieve acute vascular reperfusion. However, in some patients, ischemia persists despite vessel patency, a phenomenon known as "no reflow". Objective: bibliographical review of the phenomenon of non-ebb in a case. Identification of cardiovascular risk factors, coronary pre-angioplasty associated with non-reflux phenomenon in a patient with STEMI in the first 12 hours of evolution.Clinical case: a 52-year-old Caucasian female patient with the following cardiovascular risk factors: sedentary lifestyle, BMI 54.1 kg/m2, type 2 diabetes and chronic kidney disease. He enters the emergency department for having precordial pain of cardiogenic type, in the physical examination he presents bilateral infrascapular rattles. Laboratory and cabinet studies were carried out in which the exacerbation of chronic kidney disease was verified, as well as the acute coronary syndrome type of acute STEMI. An ECOTT was performed with the following findings: left ventricle expulsion fraction (LVEF) of 51%, basal lower akinesia, posterobasal and anteromedial hypokinesia. Primary angioplasty and implantation of three stents in the right coronary artery were performed, with the use of intracoronary adenosine, glycoprotein IIB/IIIA inhibitor (tirofiban), clopidogrel, acetylsalicylic acid and low molecular weight heparin. Conclusions: the phenomenon of non-ebb manifested by flow less than TIMI 3, which is a common situation in patients with acute myocardial infarction (AMI), with previous cardiovascular risk factors, which has been little described in Mexico despite its high incidence and prevalence. It is a multifactorial entity that can be prevented with the early identification of patients with AMI, having as a gold standard for the diagnosis coronary angiography, being the most accepted treatment the administration of intracoronary and systemic drugs, management of comorbidities and hemodynamic monitoring during the following hours post-revascularization.


REFERENCES

  1. Rossington JA, Sol E, Masoura K, Aznaouridis K, Chelliah R, Cunnington M, et al. No-reflow phenomenon and comparison to the normal-flow population postprimary percutaneous coronary intervention for ST elevation myocardial infarction: case-control study (NORM PPCI). Open Heart. 2020;7(2):e001215. doi: 10.1136/openhrt-2019-001215.

  2. Refaat H, Tantawy A, Gamal AS, Radwan H. Novel predictors and adverse long-term outcomes of No-reflow phenomenon in patients with acute ST elevation myocardial infarction undergoing primary percutaneous coronary intervention. Indian Heart J. 2021;73(1):35-43. doi: 10.1016/j.ihj.2020.12.008.

  3. Caixeta A, Oliveira MDP, Dangas GD. Coronary artery dissections, perforations, and the no-reflow phenomenon. In: Dangas GD, Di Mario C, Thiele H, Barlis P, Addo T, Claessen B, et al. Interventional cardiology: principles & practice. 3rd ed. Hoboken (NJ): John Wiley & Sons; 2022. p. 282-291. Available in: https://onlinelibrary.wiley.com/doi/abs/10.1002/9781119697367.ch26

  4. Niccoli G, Burzotta F, Galiuto L, Crea F. Myocardial no-reflow in humans. J Am Coll Cardiol. 2009;54:281-292.

  5. García-Méndez RC, Almeida-Gutierrez E, Serrano-Cuevas L, Sánchez-Díaz JS, Rosas-Peralta M, Ortega-Ramirez JA, et al. Reduction of no reflow with a loading dose of atorvastatin before primary angioplasty in patients with acute ST myocardial infarction. Arch Med Res. 2018;49:620-629.

  6. Rivera-Linares BM, Bedolla-Barajas M, Morales-Romero J, Jiménez-Gómez JE. Predictores de fenómeno de no reflujo después de intervención coronaria percutánea primaria. Rev Med Inst Mex Seguro Soc. 2018;52:522-529.

  7. González-Pacheco H, Arias-Mendoza A, Álvarez-Sangabriel A, Juárez-Herrera U, Damas F, Eid-Lidt G, et al. The TIMI risk score for STEMI predict in-hospital mortality and adverse events in patients with cardiogenic shock undergoing primary angioplasty. Arch Cardiol Mex. 2012;82:7-13.

  8. Gupta S, Gupta MM. No reflow phenomenon in percutaneous coronary interventions in ST-segment elevation myocardial infarction. Indian Heart J. 2016;68(4):539-551. doi: 10.1016/j.ihj.2016.04.006.

  9. Galiuto L. Optimal therapeutic strategies in the setting of post-infarct no reflow: the need for a pathogenetic classification. Heart. 2004;90(2):123-125. doi: 10.1136/hrt.2003.020800.

  10. Bouleti C, Mewton N, Germain S. The no-reflow phenomenon: State of the art. Arch Cardiovasc Dis. 2015;108(12):661-674. doi: 10.1016/j.acvd.2015.09.006.

  11. Ciofani JL, Allahwala UK, Scarsini R, Ekmejian A, Banning AP, Bhindi R, et al. No-reflow phenomenon in ST-segment elevation myocardial infarction: still the Achilles' heel of the interventionalist. Future Cardiol. 2021;17(2):383-397. doi: 10.2217/fca-2020-0077.

  12. Caiazzo G, Musci RL, Frediani L, Uminska J, Wanha W, Filipiak KJ, et al. State of the art: no-reflow phenomenon. Cardiol Clin. 2020;38(4):563-573. doi: 10.1016/j.ccl.2020.07.001.

  13. Barman HA, Kahyaoglu S, Durmaz E, Atici A, Gulsen K, Tugrul S, et al. The CHADS-VASc score is a predictor of no-reflow in patients with non-ST-segment elevation myocardial infarction. Coron Artery Dis. 2020;31(1):7-12.

  14. Yu Y, Wu Y, Wu X, Wang J, Wang C. Risk factors for no-reflow in patients with ST-elevation myocardial infarction who underwent percutaneous coronary intervention: a case-control study. Cardiol Res Pract. 2022;2022:3482518. doi: 10.1155/2022/3482518.

  15. Scarpone M, Cenko E, Manfrini O. Coronary no-reflow phenomenon in clinical practice. Curr Pharm Des. 2018;24(25):2927-2933. doi: 10.2174/1381612824666180702112536.

  16. Choo EH, Kim PJ, Chang K, Ahn Y, Jeon DS, Lee JM, et al. The impact of no-reflow phenomena after primary percutaneous coronary intervention: a time-dependent analysis of mortality. Coron Artery Dis. 2014;25(5):392-398. doi: 10.1097/MCA.0000000000000108.

  17. Eitel I, de Waha S, Wohrle J, Fuernau G, Lurz P, Pauschinger M, et al. Comprehensive prognosis assessment by CMR imaging after ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2014;64(12):1217-1226. doi: 10.1016/j.jacc.2014.06.1194.

  18. Resnic FS, Wainstein M, Lee MK, Behrendt D, Wainstein RV, Ohno-Machado L, et al. No-reflow is an independent predictor of death and myocardial infarction after percutaneous coronary intervention. Am Heart J. 2003;145(1):42-46. doi: 10.1067/mhj.2003.36.

  19. Abbate A, Kontos MC, Biondi-Zoccai GG. No-reflow: the next challenge in treatment of ST-elevation acute myocardial infarction. Eur Heart J. 2008;29(15):1795-1797. doi: 10.1093/eurheartj/ehn281.




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Med Crit. 2025;39