Rosenda BM

Language: Spanish
References: 25
Page: 35-40
PDF size: 389.29 Kb.

ABSTRACT

Introduction: oral biofilms represent a highly organized form of microbial life that contributes significantly to antimicrobial resistance. In the context of the oral cavity, these complex structures act as dynamic reservoirs of resistance and virulence genes. The capacity for genetic exchange within the biofilm poses clinical challenges, especially in chronic infections and in the colonization of medical devices by opportunistic oral microorganisms. Given the limited effectiveness of conventional antibiotics against these communities, the development of new therapeutic strategies becomes imperative. Therefore, the objective of this review is to explore the current state of knowledge on the topic. Material and methods: the search was conducted in the MEDLINE, PUBMED, SciELO, and LILACS databases, in English and/or Spanish, covering the period from 2015 to 2025. The searches were performed using the following DeCS/MeSH terms: biofilm, antibiotic resistance, genes, therapies. Results: the findings show the evolution of knowledge regarding biofilms and antibiotic resistance mechanisms, as well as new perspectives and emerging therapeutic strategies. Conclusion: a deep understanding of the biology and resistance mechanisms associated with biofilms is essential for designing more effective therapeutic strategies.

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