2026, Number 1
<< Back Next >>
Rev ADM 2026; 83 (1)
The ''super flu''. H3N2 virus will be a new pandemic.
Orellana CJE, Orellana CM, Morales CV, Leyva DJE, Hernández AME, Ricárdez EVA, Acevedo MAE
Language: Spanish
References: 16
Page: 41-44
PDF size: 374.08 Kb.
ABSTRACT
The influenza virus is a respiratory pathogen of major global relevance, responsible for pandemics and epidemics associated with high morbidity and mortality. Between October and March, it is estimated that 5-15% of the world's population becomes infected, which is associated with approximately 3 to 5 million cases of severe illness and between 290,000 and 650,000 deaths annually. Dentists constitute a high-risk group for infection due to the environment in which they carry out their professional practice, particularly within the oral cavity; therefore, it is important to adopt all preventive and protective measures to avoid possible infection with respiratory viruses, such as influenza A subtype H3N2. The aim of this study is to describe some of the characteristics of the virus, as well as the preventive methods currently available. In conclusion, the influenza H3N2 virus has shown high mortality in a population predominantly composed of elderly individuals with comorbidities. It should be considered a virus that has been present for many years, evolving from causing a pandemic to behaving as an endemic virus, initially observed in Asian countries and subsequently spreading to Western and Northern Hemisphere countries due to factors such as climatic conditions and globalization. The timely implementation of preventive measures by health services, as well as at the individual level, will help reduce the number of infections and prevent it from becoming a major public health problem.
REFERENCES
Abraham MK, Perkins J, Vilke GM, et al. Influenza in the Emergency Department: vaccination, diagnosis, and treatment: clinical practice paper approved by American Academy of Emergency Medicine Clinical Guidelines committee. J Emerg Med. 2016; 50 (3): 536-542.
Collins LF, Anderson BD, Gray GC. A case of Influenza A (H3N2) complicated by community-acquired pneumonia and death in a young healthy adult during the 2013-2014 season. Front Public Health. 2017; 5: 1.
Iuliano AD, Roguski KM, Chang HH, Muscatello DJ, Palekar R, Tempia S et al. Estimates of global seasonal influenza-associated respiratory mortality: a modelling study. Lancet. 2018; 391 (10127): 1285-1300.
Paget J, Spreeuwenberg P, Charu V, Taylor RJ, Iuliano AD, Bresee J et al. Global mortality associated with seasonal influenza epidemics: new burden estimates and predictors from the GLaMOR Project. J Glob Health. 2019; 9 (2): 020421.
Ruiz VR, Padilla-López M, Peralta HA, Martínez Bernardo J, Grande-Ratti MF, Otero-Castro V. Pacientes con Influenza A subtipo H3N2 y soporte ventilatorio durante el brote estacional en una central de emergencias en Argentina. Rev Am Med Respir. 2019; 19 (4): 259-267.
Young BE, Chen M. Influenza in temperate and tropical Asia: a review of epidemiology and vaccinology. Hum Vaccines Immunother. 2020; 16 (7): 1659-1667.
Haddadin Z, Schuster JE, Spieker AJ, Rahman H, Blozinski A, Stewart L et al. Acute respiratory illnesses in children in the SARS-CoV-2 pandemic: prospective multicenter study. Pediatrics. 2021; 148 (2): e2021051462.
Kang M, Zanin M, Wong S. Subtype H3N2 Influenza A viruses: an unmet challenge in the Western Pacific. Vaccines (Basel). 2022; 10 (1): 112. doi: 10.3390/vaccines10010112.
Zuo Z, Yang C, Ye F, et al. Trends in respiratory diseases before and after the COVID-19 pandemic in China from 2010 to 2021. BMC Public Health. 2023; 23 (1): 217.
Yang JR, Hsu SZ, Kuo CY, et al. An epidemic surge of influenza A(H3N2) at the end of the 2016-2017 season in Taiwan with an increased viral genetic heterogeneity. J Clin Virol. 2018; 99-100: 15-21.
Organización Panamericano de Salud (OPS) Ante el aumento global subclado k influenza AH3N2, la OPS llama a reforzar la vacunación y la vigilancia en las Americas. Disponible en: https://www.paho.org/es/noticias/12-12-2025-ante-aumento-global-subclado-k-influenza-ah3n2-ops-llama-reforzar-vacunacion
Rajaram S, Wojcik R, Moore C, de Lejarazu RO, de Lusignan S, Montomoli E et al. The impact of candidate influenza virus and egg-based manufacture on vaccine effectiveness: literature review and expert consensus. Vaccine. 2020; 38 (38): 6047-6056.
Taniguchi K, Ikeda S, Hagiwara Y, Tsuzuki D, Klai M, Sakai Y et al. Epidemiology and burden of illness of seasonal influenza among the elderly in Japan: a systematic literature review and vaccine effectiveness meta-analysis. Influenza Other Respir Viruses. 2021, 15 (2): 293-314.
Izurieta HS, Lu M, Kelman J, Lu Y, Lindaas A, Loc J et al. Comparative effectiveness of influenza vaccines among US medicare beneficiaries ages 65 years and older during the 2019-2020 season. Clin Infect Dis. 2020; 73 (11): e4251-e4259.
Wang W, Alvarado-Facundo E, Vassell R, Collins L, Colombo RE, Ganesan A et al. Comparison of A(H3N2) neutralizing antibody responses elicited by 2018-2019 season quadrivalent influenza vaccines derived from eggs, cells, and recombinant hemagglutinin. Clin Infect Dis. 2021; 73 (11): e4312-e4320.
Shinde V, Cho I, Plested JS, Agrawal S, Fiske J, Cai R et al. Comparison of the safety and immunogenicity of a novel Matrix-M-adjuvanted nanoparticle influenza vaccine with a quadrivalent seasonal influenza vaccine in older adults: a phase 3 randomised controlled trial. Lancet Infect Dis. 2021; 22 (1): 73-84.