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Instituto Nacional de Salud Pública

2026, Number 1

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salud publica mex 2026; 68 (1)

Glucose control among women with gestational diabetes and early offspring’s growth

Parra-Cabrera MS, Hurtado-Salgado EM, Monterrubio-Flores E, Méndez-Gómez-Humarán I, Cupul-Uicab LA

Language: English
References: 31
Page: 43-51
PDF size: 319.75 Kb.


ABSTRACT

Objective. To assess the association between glucose control during pregnancy and infant’s growth. Materials and methods. Prospective study of 130 women with gestational diabetes mellitus (GDM) followed up to three months after birth. Infant’s growth was assessed as weight-for-age (WfA), weight-for-length (WfL), and length-for-age (LfA) z-scores. The association of adequate vs. inadequate glucose control with infant’s growth was evaluated using linear mixed models. Results. Overall, glucose control during pregnancy was not associated with WfA (aβ= 0.089; 95%CI: -0.248,0.426), WfL (aβ= 0.006; 95%CI: -0.280,0.291), and LfA (aβ= 0.136; 95%CI: -0.157,0.429). We observed heterogeneity of effects by gestational age; infants with adequate control compared to inadequate had reduced WfA if they were born at ≥39 weeks. Conclusion. Glucose control of women with GDM might have little impact on their early offspring’s growth; however, gestational age might be relevant in terms of heterogeneity of effects. Future studies to confirm the latter findings are required.


REFERENCES

  1. American College of Obstetricians and Gynecologists. ACOGPractice Bulletin No. 190: Gestational diabetes mellitus. Obstet Gynecol. 2018;131(2):e49-e64. https://doi.org/10.1097/AOG.00000000000025012. American Diabetes Association.

  2. Classification and diagnosis ofdiabetes: Standards of Medical Care in Diabetes-2019. Diabetes Care.2019;42(Suppl 1):S13-S28. https://doi.org/10.2337/dc19-S002

  3. Buchanan TA, Xiang AH, Page KA. Gestational diabetes mellitus: risksand management during and after pregnancy. Nat Rev Endocrinol.2012;8(11):639-49. https://doi.org/10.1038/nrendo.2012.96

  4. Mittal R, Prasad K, Lemos JRN, Arevalo G, Hirani K. Unveiling gestationaldiabetes: an overview of pathophysiology and management. Int J Mol Sci.2025;26(5):2320. https://doi.org/10.3390/ijms26052320

  5. Barnes-Powell L. Infants of diabetic mothers: the effects of hyperglycemiaon the fetus and neonate. Neonatal Netw. 2007;26(5):283-90. https://doi.org/10.1891/0730-0832.26.5.283

  6. Mitanchez D, Yzydorczyk C, Siddeek B, Boubred F, Benahmed M, SimeoniU. The offspring of the diabetic mother-short- and long-term implications.Best Pract Res Clin Obstet Gynaecol. 2015;29(2):256-69. https://doi.org/10.1016/j.bpobgyn.2014.08.004

  7. Ahlsson F, Lundgren M, Tuvemo T, Gustafsson J, Haglund B. Gestationaldiabetes and offspring body disproportion. Acta Paediatr. 2010;99(1):89-93. https://doi.org/10.1111/j.1651-2227.2009.01532.x

  8. Wang H, Li N, Chivese T, Werfalli M, Sun H, Yuen L, et al. IDF DiabetesAtlas: estimation of global and regional gestational diabetes mellitusprevalence for 2021 by International Association of Diabetes in PregnancyStudy Group’s Criteria. Diabetes Res Clin Pract. 2022;183:109050. https://doi.org/10.1016/j.diabres.2021.109050

  9. Wacher NH, Gómez-Díaz RA, Ascencio-Montiel IJ, Fernández-GarateJE, Valdez-González LA, Fresnedo CQ. Incidence of gestational diabetesmellitus in Mexico from 2008 to 2023. Arch Med Res. 2025;57(2):103288.https://doi.org/10.1016/j.arcmed.2025.103288

  10. Barquera S, Hernández-Barrera L, Oviedo-Solís C, Rodríguez-RamírezS, Monterrubio-Flores E, Trejo-Valdivia B, et al. Obesidad en adultos. SaludPublica Mex. 2024;66(4):414-24. https://doi.org/10.21149/15863

  11. Mitanchez D, Ciangura C, Jacqueminet S. How can maternal lifestyleinterventions modify the effects of gestational diabetes in the neonateand the offspring? A systematic review of meta-analyses. Nutrients.2020;12(2):353. https://doi.org/10.3390/nu12020353

  12. Ong KK, Ahmed ML, Emmett PM, Preece MA, Dunger DB. Associationbetween postnatal catch-up growth and obesity in childhood: prospectivecohort study. BMJ. 2000;320(7240):967-71. https://doi.org/10.1136/bmj.320.7240.967

  13. Parra-Cabrera MS, Delgado-Ramírez JZ, Ángeles-Llerenas AR,Hurtado-Salgado E, Gómez-Humarán IM. Weight gain during pregnancyand the probability of macrosomia in women with gestational diabetes.Salud Publica Mex. 2024;66(6):807-15. https://doi.org/10.21149/15577

  14. Hurtado-Salgado E. Supplemental material Glucose control amongwomen with gestational diabetes and early offspring’s growth. Figshare,2025. https://doi.org/10.6084/m9.figshare.29983396.v1

  15. World Health Organization. Patrones de Crecimiento del Niño dela OMS: Curso de capacitación sobre la evaluación del crecimiento delniño. Geneva: WHO, 2008 [cited September 24, 2024]. Available from:https://www3.paho.org/hq/dmdocuments/2009/Module_G_Final.pdf

  16. World Health Organization. Physical status: the use and interpretationof anthropometry. Report of a WHO Expert Committee. Switzerland:WHO, 1995 [cited September 24, 2024]. Available from: https://www.who.int/publications/i/item/9241208546

  17. Digitale JC, Martin JN, Glymour MM. Tutorial on directed acyclicgraphs. J Clin Epidemiol. 2022;142:264-67. https://doi.org/10.1016/j.jclinepi.2021.08.001

  18. World Health Organization. WHO child growth standards: headcircumference-for-age, arm circumference-for-age, triceps skinfoldfor-age and subscapular skinfold-for-age, methods and development.Geneva: WHO, 2007. Available from: https://www.who.int/publications/i/item/9789241547185

  19. Silva AL, Amaral AR, Oliveira DS, Martins L, Silva MR, Silva JC. Neonataloutcomes according to different therapies for gestational diabetes mellitus.J Pediatr. 2017;93(1):87-93. https://doi.org/10.1016/j.jped.2016.04.004

  20. Scifres CM. Short- and long-term outcomes associated with largefor gestational age birth weight. Obstet Gynecol Clin North Am.2021;48(2):325-37. https://doi.org/10.1016/j.ogc.2021.02.005

  21. Tarry-Adkins JL, Aiken CE, Ozanne SE. Neonatal infant and childhoodgrowth following metformin versus insulin treatment for gestationaldiabetes: A systematic review and meta-analysis. PLoS Med.2019;16(8):e1002848. https://doi.org/10.1371/journal.pmed.1002848

  22. Yu DQ, Xu GX, Teng XY, Xu JW, Tang LF, Feng C, et al. Glycemic controland neonatal outcomes in women with gestational diabetes mellitustreated using glyburide, metformin, or insulin: a pairwise and networkmeta-analysis. BMC Endocr Disord. 2021;21:199. https://doi.org/10.1186/s12902-021-00865-9

  23. Cauzzo C, Chiavaroli V, Di Valerio S, Chiarelli F. Birth size,growth trajectory and later cardio-metabolic risk. Front Endocrinol.2023;14:1187261. https://doi.org/10.3389/fendo.2023.1187261

  24. Singhal A. Long-term adverse effects of early growth accelerationor catch-up growth. Ann Nutr Metab. 2017;70(3):236-40. https://doi.org/10.1159/000464302

  25. Zheng M, Lamb KE, Grimes C, Laws R, Bolton K, Ong KK, et al. Rapidweight gain during infancy and subsequent adiposity: a systematic reviewand meta-analysis of evidence. Obes Rev. 2018;19(3):321-32. https://doi.org/10.1111/obr.12632

  26. Langer O, Levy J, Brustman L, Anyaegbunam A, Merkatz R, DivonM. Glycemic control in gestational diabetes mellitus-How tight is tightenough: Small for gestational age versus large for gestational age? AmJ Obstet Gynecol. 1989;161(3):646-53. https://doi.org/10.1016/0002-9378(89)90371-2

  27. Nouhjah S, Shahbazian H, Latifi SM, Malamiri RA, Ghodrati N. Bodymass index growth trajectories from birth through 24 months in Iranianinfants of mothers with gestational diabetes mellitus. Diabetes MetabSyndr. 2019;13(1):408-12. https://doi.org/10.1016/j.dsx.2018.10.002

  28. Aris IM, Rifas-Shiman SL, Li LJ, Yang S, Belfort MB, Thompson J, et al. Associationof Weight for Length vs. Body Mass Index during the first 2 yearsof life with cardiometabolic risk in early adolescence. JAMA Netw Open.2018;1(5):e182460. https://doi.org/10.1001/jamanetworkopen.2018.2460

  29. Nouhjah S, Shahbazian H, Shahbazian N, Jahanfar S, Jahanshahi A, CheraghianB, et al. Early postpartum metabolic syndrome in women with orwithout gestational diabetes: Results from Life after Gestational DiabetesAhvaz cohort study. Diabetes Metab Syndr. 2018;12(3):317-23. https://doi.org/10.1016/j.dsx.2017.12.027

  30. Santos-Martín MT, Gómez-Santos E, Torres-Del-Pino M, Toledo-Muñoz-Cobo G, Pérez-Hernández A. Gestational and pregestational diabetes:Perinatal characteristics and neonatal morbidity. An Pediatr Engl Ed.2021;21(2):173-79. https://doi.org/10.1016/j.anpedi.2021.04.005

  31. Monod C, Kotzaeridi G, Linder T, Eppel D, Rosicky I, Filippi V, et al.Prevalence of gestational diabetes mellitus in women with a family historyof type 2 diabetes in first-and second-degree relatives. Acta Diabetol.2023;60(3):345-51. https://doi.org/10.1007/s00592-022-02011-w




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