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Organo Oficial de la Sociedad Mexicana de Urología
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2025, Number 4

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Rev Mex Urol 2025; 85 (4)

Polyomavirus in an immunocompetent 6-year-old girl

Naranjo OD, Palaoro L
Full text How to cite this article

Language: Spanish
References: 6
Page: 1-6
PDF size: 394.79 Kb.


Key words:

immunocompetent girl, immunocytochemistry, polymerase chain reaction, Polyomavirus.

ABSTRACT

Clinical case description: A 6-year-old girl was admitted to the hospital with diffuse abdominal pain and discomfort when urinating. She was diagnosed with gastroenteritis and a urinary tract infection. Urine examination subsequently showed traces of protein, some pyocytes, and Decoy cells, characteristic of a polyomavirus infection. The diagnosis was confirmed by plasma PCR and immunostaining of capsid antigens in urine cells.
Relevance: Polyomavirus infection in children goes unnoticed unless the urinary sediment is searched for infected cells. The viruses remain largely inactive until adulthood, where they can reactivate in immunosuppressed individuals.
Clinical implications: In children with fever, abdominal pain, or increased nasopharyngeal secretion, it is important to always perform a urine sediment examination for decoy cells; otherwise, primary polyomavirus infections would go undetected.
Conclusions: To our knowledge, only two cases of primary infection in children have been reported so far, and this is the second. Urine testing is essential to detect the presence of decoy cells.


REFERENCES

  1. Palamas M, Rocher AE, Sardi-Segovia M,Harriet LA, Palaoro LA. Symptomatic BKvirus infection in an immunocompetent childdiagnosed on urine cytology. Cytopathology:Official Journal of the British Society for ClinicalCytology. 2012;23(4): 274–275. https://doi.org/10.1111/j.1365-2303.2011.00862.x.

  2. Mayberry CL, Bond AC, Wilczek MP,Mehmood K, Maginnis MS. Sending mixedsignals: polyomavirus entry and trafficking.Current Opinion in Virology. 2021;47: 95–105.https://doi.org/10.1016/j.coviro.2021.02.004.

  3. Burgos D, Jironda C, Martín M, González-Molina M, Hernández D. Nefropatía asociadaa infección por poliomavirus BK. Nefrología.2010;30(6): 613–617. https://doi.org/10.3265/Nefrologia.pre2010.Oct.10587.

  4. Mayberry CL, Maginnis MS. Taking theScenic Route: Polyomaviruses Utilize MultiplePathways to Reach the Same Destination.Viruses. 2020;12(10): 1168. https://doi.org/10.3390/v12101168.

  5. Cook L. Polyomaviruses. MicrobiologySpectrum. 2016;4(4). https://doi.org/10.1128/microbiolspec.DMIH2-0010-2015.

  6. Helle F, Brochot E, Handala L, Martin E,Castelain S, Francois C, et al. Biology of theBKPyV: An Update. Viruses. 2017;9(11): 327.https://doi.org/10.3390/v9110327.




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Rev Mex Urol. 2025;85