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2026, Number 1

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Rev Mex Traspl 2026; 15 (1)

Association of graft dysfunction in patients undergoing liver transplantation and massive transfusion admitted to the Intensive Care Unit of the «La Raza» National Medical Center

Vázquez-Melchor M, Canedo-Castillo NA

Language: Spanish
References: 17
Page: 8-15
PDF size: 295.37 Kb.


ABSTRACT

Introduction: liver transplantation is the treatment of choice in patients with acute liver failure and end-stage liver disease with coagulation factor abnormalities and a high risk of bleeding during the immediate postoperative period; massive transfusion remains an effective therapy to improve blood volume and correct coagulopathy, but its association with graft dysfunction and mortality has not been studied. Objective: to analyze the association of graft dysfunction in patients undergoing liver transplantation and massive transfusion admitted to the Intensive Care Unit of the National Medical Center «La Raza». Material and methods: observational, retrospective, single-center, descriptive and analytical study; with a randomized probabilistic sample that included 78 orthotopic liver transplant patients and massive transfusion, to analyze their association with a bivariate and χ2 analysis. Results: of the total number of patients, 40 were divided into two groups: 40 with graft dysfunction and 38 without graft dysfunction. The median age was 50 years [IQR 27- 69], 50% (n = 39) were women, 18% (n = 14) underwent massive transfusion, 51.3% (n = 40) had some degree of graft dysfunction, 61% (n = 60) experienced delayed graft function, and mortality was 10.3% (n = 8) in the group with graft dysfunction, a significant difference (p = 0.001). Conclusions: there is no association of graft dysfunction in patients with massive transfusion in patients undergoing liver transplantation and other factors should be studied to reduce the risk of graft dysfunction and ensure patient survival.


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