Fuentes VM, López MIN, Sánchez SMA, Ríos BER

Language: Spanish
References: 9
Page: 30-34
PDF size: 174.97 Kb.

ABSTRACT

Prostatic adenocarcinoma with signet-ring cells (SRCC) is a rare morphological variant characterized by high histological grade and associated with poor prognosis. We report the case of an 81-year-old male who presented with acute urinary retention. Laboratory studies revealed a serum prostate-specific antigen (PSA) level of 171 ng/mL. A transurethral resection of the prostate (TURP) was performed, revealing a malignant epithelial neoplasm. The tumor was composed of fused glandular structures and solid areas, with cells exhibiting vacuolated cytoplasm and eccentrically displaced nuclei, consistent with signet-ring morphology. The final diagnosis was acinar prostatic adenocarcinoma with a signet-ring cell component, ISUP grade 5 (Gleason 9 [5+4]), with perineural invasion.
This case adds to the limited literature on this rare entity, highlighting the crucial importance of morphological and immunohistochemical recognition for accurate and timely diagnosis.

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