2023, Number 1
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Rev Cubana Farm 2023; 56 (1)
Modification of the manufacturing process of Hair Biofortifying agent obtained from human placenta
Lauzán AE, González HY, Riccardi SY
Language: Spanish
References: 24
Page: 1-14
PDF size: 324.51 Kb.
ABSTRACT
Introduction: Hair biofortifier is a hydroalcoholic extract of human placenta that stimulates hair growth. The product has presented problems in the scaling process due to the fact that it is not adequately filtered, thus affecting the organoleptic characteristics and microbiological values.
Objective: To modify the production process of the hair biofortifier to achieve the filtration of the product through filtering plates.
Methods: The extracting solvent was modified. Purified water was replaced by saline solution (NaCl 0.043mol. L-1). Six laboratory batches were made and characterized by physicochemical tests such as organoleptic characteristics, pH, density, alcohol percentage and protein determination. An industrial batch was prepared using the same methodology as the batches prepared in the laboratory. It was distilled through a filter press equipped with 24.7 micron Italian cellulose filter plates.
Results: With the salt extraction, the colloidal particles that were in suspension precipitated and were able to decant, which facilitated the filtration process. In addition, the salt helped to solubilize the proteins, so that higher values were obtained compared to the aqueous extraction. Both in the six batches carried out at laboratory and industrial levels, a product was obtained that complies with the organoleptic characteristics and microbiological parameters.
Conclusions: The extraction process of the hair biofortifier was modified and a product that complies with all the quality parameters was obtained. The protein values of the product were increased.
REFERENCES
Miyares C. La Histoterapia Placentaria en algunas afecciones dermatológicas. Cuba: Editorial Palacio de las Convenciones; 1994.
Miyares C, Roque S, Taboas M. Empleo de bioestimulinas placentarias por vía tópica en el tratamiento de la Alopecia. III Jornada de Balance Científico-Técnico de la Empresa de Laboratorios Técnicos de Medicamentos del Ministerio de Salud Pública. Editorial Palacio de las Convenciones, Cuba; 1994.
Miyares E. Pilotrofina y Champú de Placenta: Efectividad terapéutica en dermatitis seborreica del cuero cabelludo [tesis de especialista]. Universidad de Ciencias Médicas de La Habana, Cuba; 2010.
Lago G, Melgares P, Coto G, Oruña L, Jiménez M. Empleo de placas filtrantes cubanas en el proceso de producción de melagenina loción. Revista Cubana de Farmacia. 1999 [acceso 18/05/2021];33(3). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75151999000300002
Burton R. What is a Filter Press and How Does It Work?. E.U.A, Florida: HANDEX; 2021 [acceso 8/03/2021]. Disponible en: https://www.hcr-llc.com/blog/what-is-a-filter-press-and-how-does-it-workDisponible en: https://www. sciencedirect. com/science/article/abs/pii/S0308814615006366
Oficina Nacional de Normalización. NC 68: 2015: Perfumería y Cosmética. Límite microbiano. Determinaciones para productos cosméticos. La Habana, Cuba: Oficina Nacional de Normalización; 2015. [acceso 30/03/2022]. Disponible en: http://www.nconline.cubaindustria.cu/
Wall D, Meah N, Fagan N, York K, Sinclair R. Advances in hair growth. Fac Rev. 2022 [acceso 30/03/2021];11:1. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808739/
Hosking A, Juhasz M, Atanaskova N. Complementary and Alternative Treatments for Alopecia: A Comprehensive Review. Skin Appendage Disord. 2019 [acceso 30/03/2022];5(2):72-89. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388561/
Won J, Yoon J, Byoungduck P, Hae J, Ho Y, Lee S et al. Hair Metabolomics in Animal Studies and Clinical Settings. Molecules. 2019;24(12),2195. DOI: 10.3390/molecules24122195
Oficina Nacional de Normalización. NC 1085: 2015: Norma Cubana Cosméticos, agentes activos de superficie, limpiadores, desinfectantes y ambientadores – Pruebas organolépticas-métodos de ensayo. La Habana, Cuba: Oficina Nacional de Normalización; 2015. [acceso 30/03/2022]. Disponible en: http://www.nconline.cubaindustria.cu/
Oficina Nacional de Normalización. NC 836: 2011: Norma Cubana Cosméticos, agentes activos de superficie, limpiadores, desinfectantes y ambientadores – Determinación del pH. La Habana, Cuba: Oficina Nacional de Normalización; 2011. [acceso 30/03/2022]. Disponible en: http://www.nconline.cubaindustria.cu/
Oficina Nacional de Normalización. NC 290: 2007: Norma Cubana Bebidas alcohólicas. Determinación del grado alcohólico en alcoholes, bebidas alcohólicas destiladas, vinos, licores, bebidas alcohólicas preparadas, cocteles y extractos hidroalcólicas. La Habana, Cuba: Oficina Nacional de Normalización; 2007. [acceso 30/03/2022]. Disponible en: http://www.nconline.cubaindustria.cu/
Oficina Nacional de Normalización. NC 1086: 2015: Norma Cubana Cosméticos, agentes activos de superficie. Determinación de densidad en líquidos y semisólidos. La Habana, Cuba: Oficina Nacional de Normalización; 2015. [acceso 30/03/2022]. Disponible en: http://www.nconline.cubaindustria.cu/
Marques M. Método de Lowry. Knoow. Enciclopedia temática; 2018. [acceso 30/03/2022]. Disponible en: https://knoow.net/es/ciencias-tierra-vida/biologia-es/metodo-de-lowry/
Blaak J, Staib P. The Relation of pH and Skin Cleansing. Curr Probl Dermatol. 2018 [acceso 30/03/2022];54:132-42. Disponible en: https://pubmed.ncbi.nlm.nih.gov/30130782/
Bigliardi P. Role of Skin pH in Psoriasis. CurrProblDermatol. 2018 [acceso 30/03/2022];54:108-14. Disponible en: https://pubmed.ncbi.nlm.nih.gov/30130779/
www.ChemicalSafetyFacts.org. Ethanol (Ethyl Alcohol). Updated January 21; 2022 [acceso 30/03/2022]. Disponible en: https://www.chemicalsafetyfacts.org/ethanol/
Kramer A, Below H, Bieber N, Kampf G, Toma C, Huebner N, et al. Quantity of ethanol absorption after excessive hand disinfection using three commercially available hand rubs is minimal and below toxic levels for humans. BMC Infect Dis. 2007 [acceso 30/03/2022];11;7:117. Disponible en: https://pubmed.ncbi.nlm.nih.gov/17927841/
Calatayud M. Estudio de la absorción transdérmica de fármacos para la migraña. [tesis doctoral]. España: Universidad Cardenal Herrera, 2013 [acceso 30/03/2022]. Disponible en: https://repositorioinstitucional.ceu.es/jspui/bitstream/10637/6082/4/Estudio_Calatayud_UCHCEU_Tesis_2013.pdf
Halla N. Cosmetics Preservation: A Review on Present Strategies. Molecules. 2018 [acceso 30/03/2022];23(7):1571. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099538/
Zhuang-Li K, Sheng-Jie H, Dong-Yang Z, Han-jun M. Effect of Sodium Chloride and Processing Methods on Protein Aggregation, Physical-Chemical and Rheological Properties of Pork Batters. International Journal of Food Engineering. 2018 [acceso 30/03/2022;14(5-6)]. Disponible en: https://www.degruyter.com/document/doi/10.1515/ijfe-2017-0319/html
Kang B, Tang H, Zhao Z, Song S. Hofmeister Series: Insights of Ion Specificity from Amphiphilic Assembly and Interface Property. ACS Omega. 2020. [acceso 30/03/2022];5(12):6229-39. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114165/
Hyde A, Zultanski S, Waldman J, Zhong Y, Shevlin M, Peng F. General Principles and Strategies for Salting-Out Informed by the Hofmeister Series. Org. Process Res. Dev. 2017;21:1355-70. DOI: 10.1021/acs.oprd.7b00197
López T. Efecto hofmeister en sistemas coloidales. [tesis doctoral]. España: Universidad de Granada, 2006 [acceso 30/03/2022]. Disponible en: https://digibug.ugr.es/handle/10481/1309