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2025, Number 1

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Rev Cent Dermatol Pascua 2025; 34 (1)

Systematic review of trifarotene use in acne: effectiveness and side effects

Cruz-Gómez LG, Morales-Sánchez MA

Language: Spanish
References: 26
Page: 16-24
PDF size: 825.17 Kb.


ABSTRACT

Topical retinoids are widely used in dermatology. Trifarotene is a recently introduced retinoid, for which there are very few studies assessing its effectiveness and tolerance. We conducted a systematic review based on the PRISMA guideline and the RoB-2 risk of bias detection tool to determine the effectiveness and tolerance of trifarotene in the treatment of acne. Compared to placebo, trifarotene is more effective in treating acne, reducing the baseline IgA at 12 weeks, with a relative risk of 1.65 compared to placebo. Trifarotene is more effective in treating acne compared to placebo, as well as having a low number of adverse events associated with treatment. It is necessary to compare the effectiveness of trifarotene against first-line acne treatments to demonstrate its superiority.


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