2026, Number 3
<< Back Next >>
Acta Med 2026; 24 (3)
Efficacy of premedication with bromazepam vs placebo for reduction of preoperative anxiety in patients of the Angeles Mocel Hospital
Pazquel KI, Colín SVG, Alva ANV, Athié GJM
Language: Spanish
References: 12
Page: 198-202
PDF size: 536.38 Kb.
ABSTRACT
This study aims to evaluate the efficacy of premedication with
bromazepam in reducing preoperative anxiety in patients at
the Angeles Mocel Hospital. Preoperative anxiety, commonly
experienced by patients due to uncertainty about the procedure,
can negatively affect postoperative recovery. An observational,
cross-sectional, prospective study was conducted with 185
adult patients, who were randomized to receive bromazepam or
placebo. Anxiety was measured using the APAIS (Amsterdam
Preoperative Anxiety and Information Scale) scale. The
results showed that the group treated with bromazepam had
a significantly lower mean score in anxiety (6.15) compared
to the placebo group (11.5), with a statistically significant
difference (p = 0.009). In addition, anxiety was higher in women.
It concludes that premedication with bromazepam is effective
in reducing preoperative anxiety, improving patient satisfaction
and potentially favoring a faster and less complicated recovery.
REFERENCES
Song SW, Jin Y, Lim H, Lee J, Lee KH. Effect of intramuscularmidazolam premedication on patient satisfaction in womenundergoing general anaesthesia: a randomised control trial.BMJ Open. 2022; 12 (6): e059915. Available in: http://dx.doi.org/10.1136/bmjopen-2021-059915
Gürler H, Yilmaz M, Türk KE. Preoperative anxiety levels in surgicalpatients: A comparison of three different scale scores. J PerianesthNurs. 2022; 37 (1): 69-74. Available in: http://dx.doi.org/10.1016/j.jopan.2021.05.013
Honig AJ, Galassi MG, Ogungbe OO, Uranga T, Cuevas DK.Implementation of aromatherapy, a nonpharmacological intervention,to reduce anxiety during the preoperative period. J Perianesth Nurs.2023; 38 (2): 206-212. Available in: http://dx.doi.org/10.1016/j.jopan.2022.06.011
Guerrier G, Pisanu G, Baillard C. Assessing preoperative anxiety:Nurses versus health care assistants. J Perianesth Nurs. 2021; 36 (5):
514-517. Available in: http://dx.doi.org/10.1016/j.jopan.2020.09.0215. Huang YL, Xu N, Huang ST, Wang ZC, Cao H, Yu XR et al. Impact ofmusic therapy on preoperative anxiety and degree of cooperationwith anesthesia induction in children with simple congenital heartdisease. J Perianesth Nurs. 2021; 36 (3): 243-246. Available in: http://dx.doi.org/10.1016/j.jopan.2020.08.004
Cortiñas M, Oya B, Caparros P, Cano G, Ibarra M, Martínez L.Premedicación con ketamina-midazolam oral en pacientes nocolaboradores en cirugía mayor ambulatoria. Rev Esp AnestesiolReanim. 2010; 57 (8): 479-485. Disponible en: http://dx.doi.org/10.1016/s0034-9356(10)70708-8
Bumin Aydin G, Yüksel S, Ergil J, Polat R, Akelma FK, Ekici M,Sayın M, Odabas O. The effect of play distraction on anxietybefore premedication administration: a randomized trial. J ClinAnesth. 2017; 36: 27-31. Available in: http://dx.doi.org/10.1016/j.jclinane.2016.04.044
Boussofara M. Service d’anesthésie-réanimation, Centre detraumatologie et des grands brûlés. Ben Arous, Tunis, Tunisie. Facultéde médecine de Tunis, 6, rue Omar Ibn El Ass, Khaznadar, Bardo;Tunisie; 2017.
Méndez-Meneses KJ, Rebolledo-García ML, Díaz-Chacón S,Rodríguez-Vázquez LA, Acosta-Maldonado BL, Mantilla-Maya B,González-Rodríguez E, Aguilar Ponce JL et al. Validación de la Escalade Ansiedad Peroperatoria y de Información Ámsterdam (APAIS) enmujeres latinoamericanas con cáncer de mama: Estudio México-Costa Rica. Psicooncología. 2019; 16 (1): 73-88.
Gómez BLM, Ocampo AF, Orozco AJA, Caicedo SJ. Eficacia de lapremedicación anestésica en el paciente pediátrico con midazolamoral y acetaminofén. Estudio observacional. Colombian Journal ofAnestesiology. 2013; 41 (1): 4-9.
Andersson V, Bergstrand J, Engström A, Gustafsson S. The impact ofpreoperative patient anxiety on postoperative anxiety and quality ofrecovery after orthopaedic surgery. J Perianesth Nurs. 2020; 35 (3):260-264.
Burton D, King A, Bartley J, Petrie KJ, Broadbent E. The surgical anxietyquestionnaire (SAQ): development and validation. Psychol Health.2019; 34 (2): 129-146. Available in: http://dx.doi.org/10.1080/08870446.2018.1502770