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2026, Number 3

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Acta Med 2026; 24 (3)

A comparative study of the efficacy of surgical antibiotic prophylaxis based on ASHP, CDC, and WHO guidelines for the prevention of systemic infections in the pediatric population

Córdova GA, Silva RH

Language: Spanish
References: 14
Page: 243-246
PDF size: 535.12 Kb.


ABSTRACT

Surgical infections are a significant cause of pediatric morbidity. Surgical antibiotic prophylaxis (SAP) reduces postoperative complications, although its impact on systemic infections remains unclear. A retrospective comparative study was conducted involving 330 pediatric patients who underwent major surgery. They were divided into two groups: adequate SAP according to the American Society of Health-System Pharmacists (ASHP), the Centers for Disease Control and Prevention (CDC), and the World Health Organization (WHO) guidelines, and no prophylaxis or incorrect administration. The incidence of systemic infections was 3.6% (12 cases), all in the group without SAP (0 vs 7%, p ‹ 0.01; RR 7.0; 95% CI: 1.9-25.5). The results confirm that appropriate APE prevents systemic infections and support Antimicrobial Stewardship Programs (ASP).


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