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2025, Number 4

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Enf Infec Microbiol 2025; 45 (4)

Human papillomavirus frequency in breast cancer biopsies in patients from a hospital in Chiapas

Domínguez-Arrevillaga S, Pineda-Aguilar D, Sánchez-González RA, Vázquez-Vázquez S, Domínguez-Espinoza S, Trujillo-Vizuet MG

Language: Spanish
References: 21
Page: 177-180
PDF size: 207.70 Kb.


ABSTRACT

Objective. To determine the frequency of human papillomavirus (HPV) in biopsies from patients with breast cancer treated at the Ciudad Salud Regional High Specialty Hospital.
Materials and methods. A descriptive, cross-sectional, and ambispective study was conducted. Paraffin-embedded biopsy samples diagnosed with breast cancer (bc) were used. DNA extraction was performed following the instructions for the Macherey-Nagel™ NucleoSpin™ DNA FFPE XS kit. The quality and integrity of the dna extraction process were validated on an agarose gel. The β-globin and MY 09/11 identification techniques for human papillomavirus (HPV) were subsequently performed.
Results. A total of 252 samples were identified, of which 120 met the inclusion criteria; 55% (n = 66) of the samples were diagnosed with BC, and 45% (n = 54) had another pathological diagnosis. A total of 9% (n = 6) HPV positive cases were found.
Conclusions. The HPV prevalence in BC was 9% (6/66). No association between the presence of HPV and the development of BC was found.


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