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2026, Number 1

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Arch Inv Mat Inf 2026; 17 (1)

Perinatal and postnatal factors determining germinal matrix-intraventricular hemorrhage in premature infants in a neonatal intensive care unit

Rodríguez-Balderrama I, Durón-Tábora I, Alanís-García PJ, Soto-Alonso IY, Rosales-Solís GM, Nieto-Sanjuanero A, Cárdenas-del CBG

Language: Spanish
References: 25
Page: 15-22
PDF size: 674.33 Kb.


ABSTRACT

Introduction: germinal matrix-intraventricular hemorrhage (GMH-IV) is a lesion whose incidence and severity are inversely proportional to gestational age and weight. The objective of this study was to analyze which perinatal and postnatal factors contribute to the development of GMH-IV. Material and methods: this is an observational, comparative, retrospective case-control study. The records of premature neonates who presented GMH-IV from January 1, 2023, to December 31, 2024, were analyzed. The sample was divided into two groups for analytical comparison: the first group comprised premature neonates with intraventricular hemorrhage and the control group comprised newborns without hemorrhage. A univariate analysis was first performed, followed by binary logistic regression. Results: during the study period, there were 8,463 births, with 810 neonates admitted to the Neonatal Intensive Care Unit (NICU), of which 513 (63.4%) were premature, of which 202 were born between 24 and 33 weeks. In this latter age group, there were 34 patients with HMG-IV (with an incidence of 16.8%), and these were compared with 34 without hemorrhage. Statistical significance (p < 0.05) was observed for the group with hemorrhage in the weight range of 1,001-1,500 grams and with proven early sepsis. In infants without hemorrhage, mothers received more maturation inducers (51.5% vs 17.6% (p < 0.05). Conclusions: risk factors for HMG-IV were premature births weighing less than 1,500 grams and a diagnosis of proven early sepsis. The use of maturation inducers was a protective factor, with an 85.2% chance of avoiding intraventricular hemorrhage.


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