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2026, Number 4

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Acta Med 2026; 24 (4)

Aquaporin-4 and the glymphatic system: key players in the development of Alzheimer’s

Ramírez PEU, Hernández LJL, López NM

Language: Spanish
References: 43
Page: 427-432
PDF size: 878.71 Kb.


ABSTRACT

Alzheimer’s disease (AD) represents the most frequent cause of dementia worldwide. Various pathophysiological processes have been proposed for the development of this neurodegenerative disorder, such as the accumulation of extracellular deposits of proteins like β-amyloid (Aβ) and intracellular hyperphosphorylated tau forms. This process promotes behavioral changes as well as progressive cognitive and functional decline. Recently, the glymphatic system (GS) has gained relevance due to its role in regulating cerebral metabolites and facilitating the clearance of these neurotoxic products. Therefore, this research focuses on the genetic and physical factors affecting this system to promote the development of potential therapeutic and preventive interventions for AD.


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