2026, Number 4
<< Back Next >>
Cir Columna 2026; 4 (4)
Postoperative radiculitis following anterior lumbar interbody fusion (ALIF): a systematic review
Valdez-Aguilar JE, García-González U, Taylor-Martínez MA
Language: Spanish
References: 22
Page: 320-326
PDF size: 685.51 Kb.
ABSTRACT
Introduction: postoperative radiculitis is a relevant complication following anterior lumbar interbody
fusion (ALIF), involving inflammatory irritation of the nerve root without mechanical compression.
Reported incidence ranges from 5-30%, influenced by surgical parameters and patient-specific
characteristics.
Objective: to analyze the dependent and independent factors associated with
postoperative radiculitis after ALIF, describing biomechanical mechanisms, clinical relevance, and
prevention strategies.
Material and methods: a systematic review was conducted using PubMed, Scopus, and Google Scholar databases (2000-2024) with MeSH terms: radiculopathy, lumbar fusion,
anterior lumbar interbody fusion, postoperative complications. Clinical studies, comparative trials and
reviews reporting postoperative radiculitis were included. Odds Ratio (OR), p-values, and associated
predictors were extracted and categorized.
Results: surgery-dependent risk factors included excessive
disc height restoration ≥ 12 mm (OR 1.9; p = 0.09), segmental lordosis correction > 20-25o (OR 2.4;
p < 0.05), absence of posterior instrumentation (OR 2.97; p = 0.0088), and perioperative systemic
corticosteroid use (OR 6.03; p = 0.0094). Independent factors such as obesity, prior abdominal surgery,
osteoporosis, older age, and female gender did not demonstrate a statistically significant association
with radiculitis, although linked to overall postoperative complication risk and delayed neurological
recovery.
Conclusions: post-ALIF radiculitis is multifactorial, requiring individualized surgical planning,
biomechanically safe correction goals, and perioperative risk optimization. Prospective multicenter
trials are needed to establish standardized thresholds for correction and validated predictive models.
REFERENCES
Zhao E, Hirase T, Kim AG, et al. The impact of posteriorintervertebral osteophytes on patient-reported outcomemeasures after l5-s1 anterior lumbar interbody fusionand transforaminal lumbar interbody fusion. Spine (PhilaPa 1976). 2024; 49: 652-660.
Berjano P, Zanirato A, Langella F, et al. Anterior lumbarinterbody fusion (ALIF) L5-S1 with overpowering ofposterior lumbosacral instrumentation and fusion mass:a reliable solution in revision spine surgery. Eur SpineJ. 2021; 30: 2323-2332. doi: 10.1007/s00586-021-06888-z.
Compagnone D, Langella F, Cecchinato R, et al. PostoperativeL5 radiculopathy after L5-S1 hyperlordoticanterior lumbar interbody fusion (HL-ALIF) is related toa greater increase of lordosis and smaller post-operativeposterior disc height: results from a cohort study. EurSpine J. 2022; 31: 1640-1648. doi: 10.1007/s00586-022-07256-1.
Villavicencio AT, Burneikiene S. rhBMP-2-inducedradiculitis in patients undergoing TLIF: relationship todose. Spine J. 2016; 16: 1208-1213.
Malham GM, Brazenor GA, Mobbs RJ. Recombinanthuman bone morphogenetic protein-2 in spine fusion:a current review. J Spine Surg. 2022; 8: 1-17.
Khalid SI, Nunna RS, Shanker RM, et al. Bonemorphogenetic protein in anterior lumbar interbodyfusions: a propensity-matched medicare outcomeanalysis. Int J Spine Surg. 2022; 16: 706-713.
Phan K, et al. Influence of obesity on complications,outcomes, and fusion rates after anterior lumbarinterbody fusion. World Neurosurg. 2017; 107: 334-341.
Wu Y, Zhu T, Fu Z. Effects of Different IntervertebralSpace Heights on Nerve Root Tension during PosteriorLumbar Interbody Fusion. Orthop Surg. 2023; 15 (4):1196-1202. doi: 10.1111/os.13649. Epub 2023 Feb 27.PMID: 36846938; PMCID: PMC10102308.
Hartman TJ, Nie JW, MacGregor KR, Oyetayo OO,Zheng E, Singh K. Impact of gender on outcomesfollowing single-level anterior lumbar interbody fusion.J Clin Orthop Trauma. 2022; 34: 102019. doi: 10.1016/j.jcot.2022.102019.
Pumberger M, et al. Perioperative mortality after lumbarspinal fusion surgery: an analysis of epidemiologyand risk factors. Eur Spine J. 2012; 21: 1633-9. doi:10.1007/s00586-012-2298-8. Epub 2012 Apr 18. PMID:22526700; PMCID: PMC3535239.
Epstein NE, Agulnick MA. Perspective; high frequency ofintraoperative errors due to extreme, oblique, and laterallumbar interbody fusions (XLIF, OLIF, LLIF): Are they“safe”? Surg Neurol Int. 2023; 14: 346. doi: 10.25259/SNI_691_2023.
Araghi K, et al. Postoperative Radiculitis After L5-S1 Anterior Lumbar Interbody Fusion. Spine (PhilaPa 1976). 2023; 48 (18): 1317-1325. doi: 10.1097/BRS.0000000000004740. Epub 2023 Jun 1. PMID:37259185.
Jiang J, Teng Y, Fan Z, et al. Does obesity affect thesurgical outcome and complication rates of spinalsurgery? A meta-analysis. Clin Orthop Relat Res. 2014;472: 968-975.
Osler P, Ordonez E, Shafa E, Emami A. Priorabdominal surgery is associated with an increased riskof postoperative complications after anterior lumbarinterbody fusion. Spine J. 2014; 14: 1862-1869. doi:10.1016/j.spinee.2013.10.019.
Momin AA, Steinmetz MP, Kimmell KT, Mroz TE.Exploring perioperative complications of anterior lumbarinterbody fusion among patients with prior abdominalsurgery. J Neurosurg Spine. 2020; 32: 403-410. doi:10.3171/2019.9.SPINE19727.
Dong-Yeong Lee, Jeong Soon-Taek, Chan-Hwa Hong,Chang-Hwa Hong, Young-Lac-Choi. Risk factors of cagesubsidence after posterior lumbar interbody fusion. Journalof Korean Society of Spine Surgery, 2016; 23: 100-107.
Huang Y, Chen Q, Liu L, et al. Vertebral bone qualityscore to predict cage subsidence following obliquelumbar interbody fusion. J Orthop Surg Res. 2023; 18,258. Available in: https://doi.org/10.1186/s13018-023-03729-1
Lewandrowski KU, Ransom NA, Yeung A. Subsidenceinducedrecurrent radiculopathy after staged two-levelstandalone endoscopic lumbar interbody fusion with athreaded cylindrical cage: a case report. J Spine Surg.2020; 6: S286-S293.
Salamanna F, Contartese D, Tschon M et al. Sex andgender determinants following spinal fusion surgery: ssystematic review of clinical data. Front Surg. 2022; 9:983931.
Ciobanu-Caraus O, Grob A, Rohr J, et al. Sex differencesin patient-rated outcomes after lumbar spinal fusion fordegenerative disease: a multicenter cohort study. Spine(Phila Pa 1976). 2025; 50: 924-931.
Tsujimoto T, Higashikawa A, Miaki K, et al. Predictorsof persistent postoperative numbness following lumbarfusion in patients older than 75 years: a minimum 2-yearfollow-up. Neurospine. 2024; 21: 215-224.
Dindo D, Demartines N, Clavien PA. Classification ofsurgical complications: a new proposal with evaluationin a cohort of 6336 patients and results of a survey. AnnSurg. 2004; 240: 205-213.