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ISSN 3061-8142 (Electronic)

2026, Number 3

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Rev Mex Anest 2026; 49 (3)

Efficacy of the combination of dexketoprofen + paracetamol for laparoscopic hysterectomy

Solano-Burbano GV, Zamora-Meraz RHR, Flores-Sánchez P

Language: Spanish
References: 24
Page: 158-161
PDF size: 860.63 Kb.


ABSTRACT

Introduction: postoperative pain after laparoscopic hysterectomy can hinder recovery. Multimodal analgesia aims to optimize its control. Objective: to compare the analgesic efficacy of intravenous dexketoprofen versus other nonsteroidal anti-inflammatory drugs (NSAIDs) in postoperative pain prevention. Material and methods: retrospective cohort study in a tertiary-level hospital in Mexico, including 55 patients: dexketoprofen + paracetamol (n = 27) vs other NSAIDs + paracetamol (n = 28). Baseline data, analgesic rescue, pain score (ENA), adverse events, and hospital stay were analyzed. Results: no significant differences in baseline variables. Dexketoprofen group showed shorter time to first rescue (p = 0.050) and lower ENA score at discharge (p = 0.013). No significant differences in rescue frequency or adverse events. Conclusions: dexketoprofen + paracetamol provides more effective postoperative analgesia than other NSAIDs, reducing pain intensity and time to first rescue.


REFERENCES

  1. Ríos-Blanquet R. Anestesia laparoscópica en procedimientos ginecológicos. Rev Mex Anestesiol. 2010;33:S48-S53.

  2. Anuario estadístico 2010. La Habana: Oficina Nacional de Estadísticas e Información [citado 2 de noviembre de 2013]; 26.

  3. Faife B. Criterios clínicos de indicación de la histerectomía laparoscópica. Cirugía basada en evidencias científicas [Tesis de doctorado]. La Habana; 2005.

  4. Sardiñas Ponce R. Histerectomía laparoscópica: experiencia en el Hospital Clínico Quirúrgico Hermanos Ameijeiras [Tesis]. La Habana: Universidad de Ciencias Médicas de La Habana; s.f.

  5. Charlton E. Treatment of postoperative pain. In: Giamberardino MA, editor. An updated review refresher course syllabus. Seattle: IASP Press; 2002. pp. 351-356.

  6. Ashburn MA, Ready LB. Postoperative pain. In: Loeser JD, editor. Bonica's management of pain. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2001.

  7. Wu ChL. Dolor agudo postoperatorio. In: Miller RD. Miller anestesia. 6a ed. España: Elsevier; 2005. pp. 2729-2749.

  8. Reyes FA, de la Cala GF. Dolor postoperatorio: analgesia multimodal. Patol Apar Locomot. 2006;2:176-188.

  9. Crews JC. Multimodal pain management strategies for office-based and ambulatory procedures. JAMA. 2002;288:629-632.

  10. Cousins M, Power I. Acute and postoperative pain. In: Wall PD, Melzack R, eds. Textbook of pain. 4th ed. Edinburgh: Churchill Livingstone; 1999. pp. 447-491.

  11. Kelly DJ, Ahmad M, Brull SJ. Preemptive analgesia II: recent advances and current trends. Can J Anaesth. 2001;48:1091-1101.

  12. Carr DB, Goudas LC. Acute pain. Lancet. 1999;353:2051-2058.

  13. Ahlers SJ, van der Veen AM, van Dijk M, et al. The use of the Behavioral Pain Scale to assess pain in conscious sedated patients. Anesth Analg. 2010;110:127-133.

  14. Kehlet H. Multimodal approach to control postoperative pathophysiology and rehabilitation. Br J Anaesth. 1997;78:606-617.

  15. Hanson KT, Thiels CA, Habermann EB. Impact of preoperative pain on the patient experience. Am Surg. 2022;88:2397-2399. doi: 10.1177/0003134820951437.

  16. Andreoletti H, Dereu D, Combescure C, Rehberg B. A systematic review and meta-analysis of three risk factors for chronic postsurgical pain: age, sex and preoperative pain. Minerva Anestesiol. 2022;88:827-841. doi: 10.23736/S0375-9393.22.16489-8.

  17. International Association for the Study of Pain (IASP). Pain Clin Updates. 2003;11(4).

  18. Brater DC, Harris C, Redfern JS, Gertz BJ. Renal effects of COX-2-selective inhibitors. Am J Nephrol. 2001;21:1-15.

  19. Oriol-López SA, Uribe-Rivera ER, Domínguez-Ramírez AG, et al. Tratamiento del dolor postoperatorio en cirugías abdominales laparoscópicas con dexketoprofeno trometamol comparado con ketorolaco trometamina. Rev Mex Anestesiol. 2018;41:96-104.

  20. Rosa-Díaz J, Navarrete-Zuazo V, Díaz-Mendiondo M. Aspectos básicos del dolor postoperatorio y la analgesia multimodal preventiva. Rev Mex Anestesiol. 2014;37:18-26.

  21. Ekmekci P, Kazak Bengisun Z, Kazbek BK, Ozis SE, Tastan H, Suer AH. The efficacy of adding dexketoprofen trometamol to tramadol with patient controlled analgesia technique in post-laparoscopic cholecystectomy pain treatment. Agri. 2012;24:63-68.

  22. Lacassie HJ, Guerrero ME, Montaña R. Anestesia para cirugía laparoscópica ginecológica. Rev Chil Anest. 2010;39:292-298.

  23. Kliethermes C, Blazek K, Giedt A, et al. Postoperative pain after single-site versus multiport hysterectomy. JSLS. 2017;21:e2017.00065.

  24. Grzesh B, Van Arsdale A, Liberman RF, et al. Use of paracervical block before laparoscopic supracervical hysterectomy. JSLS. 2018;22:e2018.00023.




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