medigraphic.com
SPANISH

Dermatología Cosmética, Médica y Quirúrgica

Órgano oficial de la Sociedad Mexicana de Cirugía Dermatológica y Oncológica, AC
  • Contents
  • View Archive
  • Information
    • General Information        
    • Directory
  • Publish
    • Instructions for authors        
  • medigraphic.com
    • Home
    • Journals index            
    • Register / Login
  • Mi perfil

2026, Number 1

<< Back Next >>

Dermatología Cosmética, Médica y Quirúrgica 2026; 24 (1)

Anatomical variability of the hair follicle cycle and hair growth dynamics

Pérez-Romero AG, Sánchez-Dueñas LE, Aceves-Villalvazo MA, Morfín-Hernández L
Full text How to cite this article

Language: Spanish
References: 18
Page: 99-105
PDF size: 220.47 Kb.


Key words:

anagen, hair follicle, hair growing cycle, hair.

ABSTRACT

BACKGROUND: The human hair follicle is a highly specialized organ whose cyclic activity determines the structural characteristics of the hair shaft according to the anatomical region. Despite its clinical relevance, quantitative data regarding growth kinetics and cycle duration remain dispersed across medical and forensic literature.
OBJECTIVE: To integrate and systematize available evidence on the anatomical variability of the follicular cycle, hair elongation rates, and the distribution of terminal versus vellus hair, contrasting adult physiology with pediatric follicular maturation.
RESULTS: The review establishes that the scalp exhibits the most prolonged cycle (anagen phase of 2–8 years) with a consistent growth rate of 10 mm/month. In contrast, regions such as eyebrows and eyelashes display brief growth phases (2–3 months and 4–10 weeks, respectively), functionally adapted for ocular protection. Complementary forensic studies reveal differential growth rates in the axilla (≈0.4 mm/day) and pubis (≈0.3 mm/day). In the pediatric population, growth velocity shows an age-dependent evolution, accelerating from 0.22 mm/day in infants to 0.38 mm/day by age three.
CONCLUSIONS: Human hair biology is defined by a functional duality: it follows a strict regional anatomical programming but retains plasticity in response to the microenvironment. The final clinical length depends not only on growth kinetics but is also modulated by molecular signaling networks (Wnt/BMP), neuroendocrine balance, and the cumulative impact of the exposome on the hair fiber.


REFERENCES

  1. Erdogˇ an B. Anatomy and physiology of hair. Hair and ScalpDisorders. Rijeka: InTech; 2017. p. 13-32.

  2. Contreras-González L. Fisiología folicular. En: Blanco S, editor.Tricología en Pediatría. 1a ed. Buenos Aires: Ediciones Journal;2025. p. 16-21.

  3. Lee SH, Platt S, Lim CH, Ito M, Myung P. The development ofhair follicles and nail. Dev Biol. 2024;513:3–11.

  4. Park S. Hair follicle morphogenesis during embryogenesis,neogenesis, and organogenesis. Front Cell Dev Biol. 2022;10:938393.

  5. Natarelli N, Gahoonia N, Sivamani RK. Integrative andmechanistic approach to the hair growth cycle and hair loss. JClin Med. 2023;12(3):893.

  6. Nguyen B, Hu JK, Tosti A. Eyebrow and eyelash alopecia:a clinical review. Am J Clin Dermatol. 2023;24(1):55–67.

  7. Kuwayama K, Miyaguchi H, Kanamori T, Tsujikawa K, YamamuroT, Segawa H, et al. Micro-segmental hair analysis: detailedprocedures and applications in forensic toxicology. ForensicToxicol. 2022;40(2):215–33.

  8. Otberg N, Richter H, Schaefer H, Blume-Peytavi U, Sterry W,Lademann J. Variations of hair follicle size and distribution indifferent body sites. J Invest Dermatol. 2004;122(1):14–9.

  9. Ruiz MO, Rovnaghi CR, Tembulkar S, Qin FF, Truong L, Shen S,et al. Linear hair growth rates in preschool children. Pediatr Res.2024;95(1):359–66.

  10. Starace M, Gurioli C, Carpanese MA, Bruni F, Piraccini BM,Patrizi A, et al. Short anagen syndrome: a case series andalgorithm for diagnosis. Pediatr Dermatol. 2021;38(5):1157–61.

  11. Lin KK, Kumar V, Geyfman M, Chudova D, Ihler AT, Smyth P,et al. Circadian clock genes contribute to the regulation of hairfollicle cycling. PLoS Genet. 2009;5(7):e1000573.

  12. Cuevas-Diaz Duran R, Martinez-Ledesma E, Garcia-GarciaM, Bajo Gauzin D, Sarro-Ramírez A, Gonzalez-Carrillo C, et al.The biology and genomics of human hair follicles: a focus onandrogenetic alopecia. Int J Mol Sci. 2024;25(2):1284.

  13. Buffoli B, Rinaldi F, Labanca M, Sorbellini E, Trink A, GuanziroliE, et al. The human hair: from anatomy to physiology. Int JDermatol. 2014;53(3):331-41.

  14. Kaewmungkun K, Kaisang S, Yokhaphachon N, Parnpai R.Advanced medical treatments for hair loss. Cell Transplant.2025;34:9636897251382318.

  15. Usman M, Naseer A, Baig Y, Jamshaid T, Shahwar M, KhurshuidS. Forensic toxicological analysis of hair: a review. Egypt JForensic Sci. 2019;9:17.

  16. Cheng Y, Lv LJ, Cui Y, Han XM, Zhang Y, Hu CX. Psychologicalstress impacts neurotrophic factor levels in patients withandrogenetic alopecia and correlates with disease progression.World J Psychiatry. 2024;14(10):1437–47.

  17. Cedirian S, Prudkin L, Piraccini BM, Santamaria J, Piquero-CasalsJ, Saceda-Corralo D. The exposome impact on hair health:etiology, pathogenesis and clinical features – Part I. An BrasDermatol. 2025;100(2):131–40.

  18. Pan L, Moog P, Li C, Steinbacher L, Knoedler S, Kükrek H,et al. Exploring the association between multidimensionaldietary patterns and non-scarring hair loss using Mendelianrandomization. Nutrients. 2025;17(15):3569.




CC BY-NC-ND

2020     |     www.medigraphic.com

Mi perfil

C?MO CITAR (Vancouver)

Dermatología Cosmética, Médica y Quirúrgica. 2026;24