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2026, Number 1

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Rev Med UAS 2026; 16 (1)

Expression of GLI1 in tumor and stromal tissue with different prognostic groups of patients with prostate cáncer

Beltrán-Ontiveros SA, López-Pulido EI, Villegas-Pineda JC, Pereira-Suárez AL, Franco-Somera DG, Moreno-Ortíz JM, Dorantes-Bernal KE, Ramírez-de-Arellano A, Rico-Fuentes C

Language: Spanish
References: 31
Page: 36-46
PDF size: 258.46 Kb.


ABSTRACT

Objective: This project aims to evaluate the expression of GLI1 in tumor tissue and cellular compartments, with different prognostic groups derived from prostate cancer tissues. Materials and methods: In this study, a comparative cross-sectional design was used to investigate GLI1 expression in tumor and stromal tissue embedded in paraffin, across different prognostic groups. After classifying the samples based on the Gleason score (GS), immunohistochemical analyses were performed to detect GLI1 in tissue sections, using an automated staining system. Results: GLI1 expression shows a significant increase as GS progresses in PCa tumor tissue, suggesting a relevant role of GLI1 in tumor progression in PCa. In stromal tissue, GLI1 expression is maintained in both the nucleus and cytoplasm as GS advances. Conclusion: GLI1 expression increases with advancing prognostic grades in PCa, observed in both the cytoplasm and nucleus across all GS levels.


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