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2026, Number 2

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Dermatología Cosmética, Médica y Quirúrgica 2026; 24 (2)

Disseminated herpes simplex in immunocompromised adults: a case report and review

Chew BE, Vega PYX, Corona FR, Palomar OMÁ, Briseño RMF, Lemini LA

Language: Spanish
References: 15
Page: 206-209
PDF size: 250.24 Kb.


ABSTRACT

Disseminated herpes simplex virus (HSV) infection is a rare condition typically associated with severe immunosuppression. Its presentation in patients with mild or unrecognized immune compromise, such as uncontrolled diabetes mellitus, is uncommon and poses a significant diagnostic challenge. We describe the case of a 54-year-old woman with uncontrolled diabetes who presented with a widespread dermatosis, initially mismanaged as a bacterial infection. Physical examination revealed multiple erythematous papulovesicles involving the head, neck, trunk, and upper extremities, along with an ulceronecrotic plaque on the forehead. The clinical suspicion of disseminated HSV was confirmed through laboratory testing, and the patient was successfully treated with intravenous acyclovir. Disseminated HSV should be considered in patients with relatively mild immunosuppression when presenting with extensive, rapidly progressive dermatologic lesions and a poor response to antibiotic therapy.


REFERENCES

  1. Cohen JI. “Herpes simplex virus and varicella-zoster virusinfections”. En: Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J. Harrison’s Principles of Internal Medicine. 20a ed.; New York, McGraw Hill, 2018: 1266-1274.

  2. Chayavichitsilp P, Buckwalter JV, Krakowski AC, Friedlander SF.“Herpes simplex”. Pediatr Rev. 2009; 30: 119-129.

  3. Whitley RJ, Roizman B. “Herpes simplex viruses”. En: KnipeDM, Howley PM. Fields Virology. 5a ed.; Philadelphia, LippincottWilliams & Wilkins, 2007: 2501-2601.

  4. Johnston C, Magaret A, Roychoudhury P, et al. “Dual-straingenital herpes simplex virus type 2 (HSV-2) infection in the US,Peru, and 8 countries in sub-Saharan Africa”. PLoS Med. 2017;14(11): e1002475.

  5. Abusrair J, AlJawad M, Radwan H, AlFaris E, Mashhour M,AlJishi Y. “Disseminated herpes simplex virus infection inimmunocompetent patient”. Open J Clin Med Case Rep. 2023;9(24): 2077.

  6. Nahmias A. “Disseminated herpes-simplex-virus infections”.N Engl J Med. 1970; 282: 684-685.

  7. Corey L, Wald A. “Maternal and neonatal herpes simplex virusinfections”. N Engl J Med. 2009; 361: 1376-1385.

  8. Patel R, Kennedy OJ, Clarke E, Geretti AM, Nilsen A,Lautenschlager S, et al. “2017 European guidelines for themanagement of genital herpes”. J Eur Acad Dermatol Venereol.2017; 31(Suppl 1): 5-10.

  9. Rimawi BH, Meserve J, Rimawi RH, Min Z, Gnann JW Jr.“Disseminated herpes simplex virus with fulminant hepatitis”.Case Rep Hepatol. 2015; 2015: 463825.

  10. James SH, Kimberlin DW. “Neonatal herpes simplex virusinfection: epidemiology and treatment”. Clin Perinatol. 2015; 42:47-59.

  11. Bowers EMR, Esianor BI, Kimura K, Lewis JS Jr, Topf MC.“Disseminated herpes simplex infection presenting asacute supraglottitis in an adult”. Head Neck Pathol. 2021; 15:1074-1081.

  12. Finlow C, Thomas J. “Disseminated herpes simplex virus: acase of eczema herpeticum causing viral encephalitis”. J R CollPhysicians Edinb. 2018; 48(1): 36-39.

  13. Li W, Madabhushi AK, Arora A, Ahmed S, Abdelhamid N,Akintokunbo EF, et al. “Disseminated cutaneous herpessimplex virus: a severe case of erythema herpeticum in aclinically immunocompetent patient”. Ann Intern Med ClinCases. 2022; 1: e220416.

  14. Erdmann N, Hewitt BA, Atkinson TP, Van Wagoner N.“Disseminated primary herpes simplex virus type 2 infection ina 22-year-old male”. Open Forum Infect Dis. 2015; 2(3): ofv092.

  15. Oliveros A, Fonseca PA, Rodríguez CA, González JM. “Infeccióndiseminada por el virus del herpes simple en el embarazo”.Biomédica. 2024; 44: 460-467.




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