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2026, Number 2

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Dermatología Cosmética, Médica y Quirúrgica 2026; 24 (2)

Multiple primary skin tumors: a literature review

Armendariz BY, Velazco ME, Ramírez SJA, González TJA, Mendoza TPG, Burgos ML

Language: Spanish
References: 16
Page: 237-241
PDF size: 181.51 Kb.


ABSTRACT

Current literature indicates that between 2% and 17% of oncology patients develop multiple primary tumors (MPTs), which are classified as either synchronous or metachronous based on their timing of presentation. The incidence of multiple primary skin tumors is particularly high; for instance, patients diagnosed with an initial keratinocyte carcinoma face a risk of up to 40% of developing a second lesion within five years. Similarly, individuals with a history of melanoma exhibit an increased predisposition to subsequent primary skin cancers of the same or distinct histological lineages. Furthermore, emerging evidence suggests a significant association between certain skin malignancies and the development of internal neoplasms. This review highlights the clinical importance of understanding the risk of subsequent primary malignancies—both cutaneous and extracutaneous—following an initial skin cancer diagnosis to optimize long-term surveillance.


REFERENCES

  1. Song F, Qureshi AA, Giovannucci EL, Fuchs CS, Chen WY, ycol. Risk of a second primary cancer after non-melanoma skincancer in white men and women: a prospective cohort study.PLoS Med. 2013;10(4):e1001433.

  2. Chattopadhyay S, Hemminki A, Försti A, Sundquist K, SundquistJ, y col. Second Primary Cancers in Patients with Invasiveand In Situ Squamous Cell Skin Carcinoma, Kaposi Sarcoma,and Merkel Cell Carcinoma: Role for Immune Mechanisms?J Invest Dermatol. 2020 Jan;140(1):48-55.e1.

  3. Schierbeck J, Vestergaard T, Bygum A. Skin Cancer AssociatedGenodermatoses: A Literature Review. Acta Derm Venereol.2019;99(4):360-369.

  4. Pan SY, Huang CP, Chen WC. Synchronous/MetachronousMultiple Primary Malignancies: Review of Associated RiskFactors. Diagnostics (Basel). 2022;12(8):1940.

  5. Tanjak P, Suktitipat B, Vorasan N, Juengwiwattanakitti P,Thiengtrong B, et al. Risks and cancer associations ofmetachronous and synchronous multiple primary cancers: a25-year retrospective study. BMC Cancer. 2021;21(1):1045.

  6. Tzeng HE, Lin CL, Tsai CH, Tang CH, Hwang WL, et al. Timetrend of multiple myeloma and associated secondary primarymalignancies in Asian patients: a Taiwan population-basedstudy. PLoS One. 2013;8(7):e68041.

  7. Colombo E, Gurizzan C, Ottini A, Caspani F, Bergamini C, et al.The association of cemiplimab plus sonidegib for synchronouscutaneous squamous cell carcinoma and basal cell carcinomaof the head and neck: Two case reports. Front Oncol.2023;13:1111146.

  8. Ghlichloo I, Jin Z, Fan R, Tong C, Starostik P, et al. SynchronousBasal Cell Carcinoma and Squamous Cell Carcinoma ofNasal Vestibule With Novel Unique Variants Identified byWhole-exome Sequencing. In Vivo. 2022;36(1):251-257. doi:10.21873/invivo.12698

  9. Wehner MR, Linos E, Parvataneni R, Stuart SE, BoscardinWJ, et al. Timing of subsequent new tumors in patients whopresent with basal cell carcinoma or cutaneous squamous cellcarcinoma. JAMA Dermatol. 2015;151(4):382-8.

  10. Wu PA, Stern RS. How likely is another nonmelanoma skincancer?: better informing patients and clinicians. JAMADermatol. 2015;151(4):369-70.

  11. Cia˛żyn´ska M, Pabianek M, Sławin´ska M, Reich A, LewandowskiB, et al. Risk Factors and Clinicopathological Features forDeveloping a Subsequent Primary Cutaneous Squamous andBasal Cell Carcinomas. Cancers (Basel). 2022;14(13):3069.

  12. van der Leest RJT, Hollestein LM, Liu L, Nijsten T, de VriesE. Risks of different skin tumour combinations after a firstmelanoma, squamous cell carcinoma and basal cell carcinomain Dutch population-based cohorts: 1989-2009. J Eur AcadDermatol Venereol. 2018;32(3):382-389.

  13. Apostu AP, Ungureanu L, Halmagyi SR, Trufin II, Șenilă SC.Multiple primary melanomas: A literature review. Medicine(Baltimore). 2023 Jul 28;102(30):e34378.

  14. Kuru H, Jokelainen J, Tasanen K, Huilaja L. Risk ofNon-cutaneous Cancers in Individuals with Basal CellCarcinoma: A Population-based Cohort Study. Acta DermVenereol. 2022;102:adv00826.

  15. Krilaviciute A, Vincerzevskiene I, Smailyte G. Basal cell skincancer and the risk of second primary cancers: a cancerregistry-based study in Lithuania. Ann Epidemiol. 2016Jul;26(7):511-514.

  16. Wheless L, Black J, Alberg AJ. Nonmelanoma skin cancerand the risk of second primary cancers: a systematic review.Cancer Epidemiol Biomarkers Prev. 2010 Jul;19(7):1686-95.




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