Argote-Collazo, Diana-Wendoline; Jaime-Almaguer, María-de-la-Luz; Campos-Macías, Pablo

Language: Spanish
References: 25
Page: 252-259
PDF size: 257.86 Kb.

ABSTRACT

Although the pathogenesis of many dermatoses is wellestablished, recent evidence suggests that atmospheric pollution significantly alters their clinical expression. As a critical component of the skin exposome, pollution exacerbates chronic inflammatory conditions, including atopic dermatitis, psoriasis, and acne. This review examines the underlying molecular mechanisms and therapeutic strategies designed to mitigate this environmental damage. Key findings indicate that pollutant toxicity—specifically from particulate matter—is mediated through three synergistic pathways in keratinocytes: activation of the aryl hydrocarbon receptor (AhR), sustained oxidative stress, and dysbiosis of the cutaneous microbiome. These pathways collectively drive skin barrier dysfunction. Current preventive and therapeutic approaches focus on modulating the nuclear factor erythroid 2–related factor 2 (Nrf2) pathway, alongside the use of antioxidants and barrier-reinforcing agents. Ultimately, integrating air quality surveillance into clinical practice and promoting public health policies are essential steps toward reducing the global burden of environment-driven dermatologic disease.

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