2026, Number 1
<< Back Next >>
Arch Med Urg Mex 2026; 18 (1)
Weaning: from mechanical ventilation: where are we and where are we going? The significance of an individualized protocol
Hernández-López GD, Gorordo-Delsol LA
Language: Spanish
References: 46
Page: 79-86
PDF size: 307.51 Kb.
ABSTRACT
Weaning, or the withdrawal from mechanical ventilation, is a
crucial process in the recovery of critically ill patients. Approximately
40% of the time a patient spends on mechanical ventilation is
dedicated to this process, highlighting its importance in avoiding
complications related to prolonged ventilation, such as respiratory
infections, lung damage, and muscle weakness. A structured weaning
protocol is essential to guide healthcare professionals in identifying
the appropriate time to initiate the process, as well as selecting
the most appropriate tools to assess the patient’s ability to breathe
independently. However, the key to successful weaning lies in individualizing
the protocol. Each patient presents unique characteristics
and clinical conditions that must be considered when planning
their withdrawal from mechanical ventilation. This individualization
helps reduce the risk of extubation failure, minimizing the need for
reintubation and optimizing clinical outcomes. Factors such as the
underlying disease, the duration of ventilation, diaphragmatic strength,
cardiovascular status, age, and comorbidities, among others,
influence the patient’s ability to be successfully extubated. Therefore,
it is necessary to personalize the approach, avoiding the routine and
generalized application of a single protocol for all patients. Having a
weaning protocol is essential to guide the process, but its success
depends on its adaptation to the specific needs and conditions of
each patient, allowing for a safe and efficient withdrawal from mechanical
ventilation.
REFERENCES
Rubulotta F, Blanch Torra L, Naidoo KD, Aboumarie HS, MathivhaLR, Asiri AY, Sarlabous Uranga L, Soussi S. Mechanical Ventilation,Past, Present, and Future. Anesth Analg. 2024; 138 (2): 308-325. doi: 10.1213/ANE.0000000000006701.
Thille AW, Boissier F, Ben-Ghezala H, Razazi K, Mekontso DessapA, Brun-Buisson C. Ventilator Settings and Monitoring VariablesAssociated with Extubation Failure in Critically Ill Patients: A RetrospectiveCohort Study. Critical Care Medicine. 2022;50(1):e45–e54. doi:10.1097/CCM.0000000000005192.
Chang MY. [A concept analysis of successful weaning from mechanicalventilation]. Hu Li Za Zhi. 2006 Oct; 53 (5):69-75. Chinese.PMID: 17004210.
Pham T, Heunks L, Bellani G, Madotto F, Aragao I, et al., WEANSAFE Investigators. Weaning from mechanical ventilation in intensivecare units across 50 countries (WEAN SAFE): a multicentre,prospective, observational cohort study. Lancet Respir Med.2023;11 (5): 465-476. doi: 10.1016/S2213-2600(22)00449-0.
Akella P, Voigt LP, Chawla S. To Wean or Not to Wean: A PracticalPatient Focused Guide to Ventilator Weaning. J Intensive CareMed. 2022; 37(11):1417-1425. doi: 10.1177/08850666221095436.
Rodríguez P., Hernández G. Desconexión de la ventilación mecánicainvasiva: búscala antes, extuba mejor. Medicina Intensiva2024; 48 (6): 356-359.DOI: 10.1016/j.medin.2024.02.008
Heunks LM, van der Hoeven JG. Clinical review: the ABC of weaningfailure--a structured approach. Crit Care. 2010; 14 (6): 245.doi: 10.1186/cc9296.
Torrini F, Gendreau S, Morel J, Carteaux G, Thille AW, AntonelliM, et al. Prediction of extubation outcome in critically ill patients: asystematic review and meta-analysis. Crit Care. 2021;25(1):391.doi:10.1186/s13054-021-03802-3.
Jaber, S., Quintard, H., Cinotti, R. et al. Risk factors and outcomesfor airway failure versus non-airway failure in the intensive care unit:a multicenter observational study of 1514 extubation procedures. CritCare 22, 236 (2018). https://doi.org/10.1186/s13054-018-2150-6
Grosu HB, Ost DE, Lee YI, Song J, Li L, Eden E, Rose K. DiaphragmMuscle Thinning in Subjects Receiving Mechanical Ventilationand Its Effect on Extubation. Respir Care. 2017; 62 (7):904–911. doi: 10.4187/respcare.05370
Menguy, J., De Longeaux, K., Bodenes, L. et al. Defining predictorsfor successful mechanical ventilation weaning, using a data-mining process and artificial intelligence. Sci Rep 13, 20483(2023). https://doi.org/10.1038/s41598-023-47452-7.
Godet T, Chabanne R, Marin J, Kauffmann S, Futier E, Pereira B,Constantin J-M: Extubation failure in brain-injured patients: Riskfactors and development of a prediction score in a preliminaryprospective cohort study. Anesthesiology 2017; 126:104–14
Namen AM, Ely EW, Tatter SB, et al. Predictors of successful extubationin neurosurgical patients. Am J Respir Crit Care Med 2001;163: 658-64. 10.1164/ajrccm.163.3.2003060
Asehnoune K, Seguin P, Lasocki S, et al. Extubation Success Predictionin a Multicentric Cohort of Patients with Severe Brain Injury.Anesthesiology 2017; 127: 338–346 doi: https://doi.org/10.1097/ALN.0000000000001725
Ribeiro EOS, Gosselink R, Moura LEdS, Correia RF, Leite WS,Araújo MdGRd, Andrade ADd, Brandão DC, Campos SL. Agreementbetween two methods for assessment of maximal inspiratorypressure in patients weaning from mechanical ventilation. AcuteCrit Care. 2022; 37 (4): 592-600. doi: 10.4266/acc.2022.00325
Telias I, Damiani F, Brochard L. The airway occlusion pressure(P0.1) to monitor respiratory drive during mechanical ventilation:increasing awareness of a not-so-new problem. Intensive CareMed. 2018; 44 (9): 1532-1535. doi: 10.1007/s00134-018-5045-8.
Sato R, Hasegawa D, Hamahata NT, Narala S, Nishida K, TakahashiK, Sempokuya T, Daoud EG. The predictive value of airwayocclusion pressure at 100 msec (P0.1) on successful weaning frommechanical ventilation: A systematic review and meta-analysis. JCrit Care. 2021; 63:124-132. doi: 10.1016/j.jcrc.2020.09.030.
Fischbach A, Wiegand SB, Simons JA, Ammon L, Kopp R, SoccoroMatos GI, Baigorri JJ, Crowley JC, Bagchi A. The VentilatoryRatio as a Predictor of Successful Weaning from a Veno-VenousExtracorporeal Membrane Oxygenator. J Clin Med. 2024; 13 (13):3758. doi: 10.3390/jcm13133758. PMID: 38999326; PMCID:PMC11242634.
Ghiani A, Tsitouras K, Paderewska J, et al. Ventilatory ratioand mechanical power in prolonged mechanically ventilatedCOVID-19 patients versus respiratory failures of other etiologies.Therapeutic Advances in Respiratory Disease. 2023; 17.doi:10.1177/17534666231155744.
Ang KL, Tobin MJ. A prospective study of indexes predicting theoutcome of trials of weaning from mechanical ventilation. N Engl JMed. 1991; 324: 1445-1450.
Li ZB, Gao XJ, Wang DH, Zhang B, Zhang ZP, Hu ZM, Xu L, QinYZ. [A multicenter study of respiratory multiple index in predictingweaning from mechanical ventilation in patients with acute exacerbationof chronic obstructive pulmonary disease]. ZhonghuaWei Zhong Bing Ji Jiu Yi Xue. 2013; 25 (6): 339-42. Chinese. doi:10.3760/cma.j.issn.2095-4352.2013.06.006. PMID: 23739566.
Montaño-Alonso EA, Jiménez-Saab NG, Vargas-Ayala G, García-Sánchez JL y col. Utilidad del índice CROP como marcadorpronóstico de extubación exitosa. Med Int Méx 2015; 31: 164-173.
Angelene Taleon-Parazo, Lucas Uy. Comparison of serial rapidshallow breathing index to serial CROP index in prediction of weaningoutcome in critical care patients. Eur Respir J 2013; 42 Suppl57: P4920
Nemer SN, Barbas CS, Caldeira JB, Cárias TC, Santos RG, AlmeidaLC, Azeredo LM, Noé RA, Guimarães BS, Souza PC. Anew integrative weaning index of discontinuation from mechanicalventilation. Crit Care. 2009; 13 (5): R152. doi: 10.1186/cc8051.
Vahedian-Azimi A, Gohari-Moghadam K, Rahimi-Bashar F, SamimA, Khoshfetrat M, Mohammadi SM, de Souza LC, MahmoodpoorA. New integrated weaning indices from mechanical ventilation:A derivation-validation observational multicenter study. Front Med(Lausanne). 2022; 9: 830974. doi: 10.3389/fmed.2022.830974.PMID: 35935785; PMCID: PMC9354807.
De Backer D. The cuff-leak test: what are we measuring? CritCare. 2005; 9 (1): 31-3. doi: 10.1186/cc3031.
Kuriyama, A., Jackson, J.L. & Kamei, J. Performance of the cuffleak test in adults in predicting post-extubation airway complications:a systematic review and meta-analysis. Crit Care 24, 640(2020). https://doi.org/10.1186/s13054-020-03358-8.
Alía, I., Esteban, A. Weaning from mechanical ventilation. CritCare 4, 72 (2000). https://doi.org/10.1186/cc660
Anguel N, Monnet X, Osman D, et al. Increase in plasma proteinconcentration for diagnosing weaning-induced pulmonary oedema.Intensive Care Med 2008; 34: 1231-8. 10.1007/s00134-008-1038-3.
Pottier V, Valette X, Seguin A, et al. Diagnostic accuracy of hemoconcentrationfor pulmonary edema as the cause of weaningfailure. Minerva Anestesiol 2016; 82: 419-28.
Shahu A, Banna S, Applefeld W, et al. Liberation From MechanicalVentilation in the Cardiac Intensive Care Unit. JACC Adv. 2023Jan, 2 (1) . https://doi.org/10.1016/j.jacadv.2022.100173
Vignon P. Cardiovascular failure and weaning. Ann TranslMed. 2018; 6 (18): 354. doi: 10.21037/atm.2018.05.46. PMID:30370281; PMCID: PMC6186572.
Mayo P, Volpicelli G, Lerolle N, Schreiber A, Doelken P, Vieillard-Baron A. Ultrasonography evaluation during the weaning process:the heart, the diaphragm, the pleura and the lung. IntensiveCare Med. 2016; 42: 1107–17.
Routsi, C., Stanopoulos, I., Kokkoris, S. et al. Weaning failureof cardiovascular origin: how to suspect, detect and treat—a reviewof the literature. Ann. Intensive Care 9, 6 (2019). https://doi.org/10.1186/s13613-019-0481-3.
Dres M, Teboul JL, Anguel N, Guerin L, Richard C, Monnet X. Extravascularlung water, B-type natriuretic peptide and blood volumecontraction enable diagnosis of weaning-induced pulmonaryedema. Crit Care Med. 2014; 42:1882–9.
Baptistella AR, Mantelli LM, Matte L, Carvalho MEDRU, FortunattiJA, Costa IZ, Haro FG, Turkot VLO, Baptistella SF, de Carvalho D,Nunes Filho JR. Prediction of extubation outcome in mechanicallyventilated patients: Development and validation of the ExtubationPredictive Score (ExPreS). PLoS One. 2021 Mar 18; 16 (3):e0248868. doi: 10.1371/journal.pone.0248868. PMID: 33735250;PMCID: PMC7971695.
Al-Husinat L, Jouryyeh B, Rawashdeh A, Robba C, Silva PL, RoccoPRM, Battaglini D. The Role of Ultrasonography in the Processof Weaning from Mechanical Ventilation in Critically Ill Patients.Diagnostics (Basel). 2024 Feb 12; 14 (4): 398. doi: 10.3390/diagnostics14040398.PMID: 38396437; PMCID: PMC10888003.
Grosu HB, Ost DE, Lee YI, Song J, Li L, Eden E, Rose K. DiaphragmMuscle Thinning in Subjects Receiving Mechanical Ventilationand Its Effect on Extubation. Respir Care. 2017; 62 (7):904–911. doi: 10.4187/respcare.05370
González-Aguirre Julio E., Rivera-Uribe Claudia Paola., Rendón-Ramírez Erick Joel., Cañamar-Lomas Rogelio., Serna-RodríguezJuan Antonio., Mercado-Longoría, Roberto. Pulmonary Ultrasoundand Diaphragmatic Shortening Fraction Combined Analysisfor Extubation-Failure-Prediction in Critical Care Patients. Archivosde Bronconeumología (English Edition) 2019; 55 (4): 195-200.
Pirompanich, P., Romsaiyut, S. Use of diaphragm thickening fractioncombined with rapid shallow breathing index for predictingsuccess of weaning from mechanical ventilator in medical patients.J Intensive Care 6, 6 (2018). https://doi.org/10.1186/s40560-018-0277-9.
Soliman SB, Ragab F, Soliman RA, Gaber A, Kamal A. ChestUltrasound in Predication of Weaning Failure. Open Access MacedJ Med Sci. 2019 14; 7 (7): 1143-1147. doi: 10.3889/oamjms.2019.277.
Caltabeloti FP, Rouby JJ. Lung ultrasound: a useful tool in theweaning process? Rev Bras Ter Intensiva. 2016; 28 (1): 5-7. doi:10.5935/0103-507X.20160002.
Soummer A, Perbet S, Brisson H, et al. Ultrasound assessment oflung aeration loss during a successful weaning trial predicts postextubationdistress. Crit Care Med. 2012; 40: 2064-72.
Thille, A. W. et al. T-piece versus pressure-support ventilation forspontaneous breathing trials before extubation in patients at highrisk of reintubation: protocol for a multicentre, randomised controlledtrial (TIP-EX). BMJ Open. 10 (11), e042619 (2020).
Subirà C, Hernández G, Vázquez A, et al. Effect of Pressure Supportvs T-Piece Ventilation Strategies During Spontaneous BreathingTrials on Successful Extubation Among Patients ReceivingMechanical Ventilation: A Randomized Clinical Trial. JAMA. 2019;321 (22): 2175–2182. doi:10.1001/jama.2019.7234
Jaber, S., Quintard, H., Cinotti, R. et al. Risk factors and outcomesfor airway failure versus non-airway failure in the intensive careunit: a multicenter observational study of 1514 extubation procedures.Crit Care 22, 236 (2018). https://doi.org/10.1186/s13054-018-2150-6