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2025, Number 1

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Rev Hematol Mex 2025; 26 (1)

Associations between hematological biomarkers and muscle health in women with sickle cell disease

Zambrano CJC, Martins RRAP, Lisboa L, Pimenta R, Tiraboschi R, de Bessa JJ

Language: English
References: 65
Page: 1-16
PDF size: 406.95 Kb.


ABSTRACT

OBJECTIVE: To investigate the association between hematological/metabolic biomarkers and handgrip strength, appendicular muscle mass, and relative muscle power in women with sickle cell disease.
MATERIALS AND METHODS: A cross-sectional study was conducted with women with sickle cell disease from a reference center. Handgrip strength was assessed via dynamometry, appendicular skeletal muscle mass by bioimpedance, and relative muscle power via the 30-second chair stand test. Fasting blood samples measured C-reactive protein, cystatin C, albumin, and rheumatoid factor.
RESULTS: There were included 46 women with a median age of 36 years. ROC curve showed good discrimination for mean corpuscular volume (area under the curve [AUC] 0.78) and mean corpuscular hemoglobin (AUC 0.79); C-reactive protein had an AUC of 0.69. Mean corpuscular volume and mean corpuscular hemoglobin were significantly associated with lower muscle mass after confounder adjustment. Age was associated with reduced muscle power (OR 1.14-1.16; 95% CI: 1.02-1.37), but not with C-reactive protein.
CONCLUSION: Mean corpuscular volume and mean corpuscular hemoglobin are promising biomarkers for assessing muscle health in women with sickle cell disease. These findings emphasize the critical need to integrate objective functional tests (grip strength, muscle power assessments) into routine clinical practice for this population.


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