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ISSN 1561-3011 (Electronic)

2022, Number 1

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Rev Cubana Invest Bioméd 2022; 41 (1)

Antioxidant markers in normotensive, pre-hypertensive and hypertensive school-age children

Alfonso RJI, Heredia RD, Fernández CD, González RE

Language: Spanish
References: 28
Page: 1-17
PDF size: 249.03 Kb.


ABSTRACT

Introduction: Hypertension in childhood is an important health problem due to the frequency with which it occurs today, unlike what happened in past decades. In hypertension it has been found that the antioxidant system is diminished.
Objective: To evaluate the endogenous antioxidant system through the levels of superoxide dismutase, catalase and reduced glutathione in normotensive, pre-hypertensive and hypertensive children according to sex and skin color.
Methods: 308 children participated in this study. Superoxide dismutase was determined by Marklund's method, catalase by Aebi's method, and glutathione reduced by Sedlak's method. A p < 0.05 was used for the significant difference between the groups studied. All tests that were used belong to the SPSS 21.0 package.
Results: In the total group, hypertensive boys were found to have a significant decrease in superoxide dismutase and catalase. In hypertensive girls, a significant decrease in superoxide dismutase and reduced glutathione was found in pre-hypertensive. Superoxide dismutase had a significant decrease in pre-hypertensive and hypertensive white-skinned children as did catalase in hypertensive children. The combined study of skin color and sex showed that pre-hypertensive and hypertensive girls with white skin had a significant decrease in superoxide dismutase and reduced glutathione.
Conclusions: The antioxidant system in children´s hypertension is altered, with superoxide dismutase being the most affected antioxidant.


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