2026, Number 3-4
<< Back Next >>
Rev Mex Cir Endoscop 2026; 27 (3-4)
Cystic neuroendocrine tumor of the pancreas solved with distal pancreatectomy with splenic preservation (Kimura technique). Case report
Huerta-Gasca KG, Lira-Cerda A, Salgado-Sánchez E, Riedel-Caballero EN, Robredo-Galindo A, Gómez-Mondragón BI, Pérez-Cervantes DH
Language: Spanish
References: 15
Page: 106-111
PDF size: 1789.00 Kb.
ABSTRACT
Introduction: cystic pancreatic neuroendocrine tumors (cPanNETs)
are uncommon and may mimic other pancreatic cystic lesions, making
preoperative diagnosis challenging. Their low frequency and the scarcity
of national reports highlight the value of documenting individual cases.
Case report: a 71-year-old man presented with mild left flank pain and
chronic diarrhea. Physical examination was unremarkable. Laboratory
tests showed elevated amylase, lipase, and alpha-fetoprotein (AFP).
Contrast-enhanced tomography identified a well-defined cystic lesion
in the pancreatic tail. Due to persistent symptoms, suspicion of a
cystic neoplasm, and the patient’s preference, laparoscopic distal
pancreatectomy was indicated. A laparoscopic spleen-preserving
distal pancreatectomy (Kimura technique) was performed, with 30 mL
blood loss and a 90-minute operative time. Histopathological analysis
confirmed a well-differentiated cystic pancreatic neuroendocrine tumor (G1), measuring 45 mm, with no lymphovascular or perineural invasion,
negative margins, and confinement of the tumor to the pancreas.
Conclusion: spleen-preserving laparoscopic distal pancreatectomy
is a safe and effective approach for cystic PanNETs of the pancreatic
tail. This case emphasizes the need to consider these tumors in the
differential diagnosis of pancreatic cystic lesions and supports the
importance of reporting national experiences to strengthen clinical and
surgical knowledge in Mexico.
REFERENCES
Van Huijgevoort NCM, del Chiaro M, Wolfgang CL, vanHooft JE, Besselink MG. Diagnosis and managementof pancreatic cystic neoplasms: current evidence andguidelines. Nat Rev Gastroenterol Hepatol. 2019; 16: 676-689. doi: 10.1038/s41575-019-0195-x.
Khanna L, Prasad SR, Sunnapwar A, Kondapaneni S,Dasyam A, Tammisetti VS et al. Pancreatic neuroendocrineneoplasms: 2020 update on pathologic and imagingfindings and classification. Radiographics. 2020; 40: 1240-1262. doi: 10.1148/rg.2020200025.
Miranda-Aguirre AP, Hernández-García S, Tenorio-TorresJA, Farías-Alarcón M, Solís Erazo-Valle A. Experienciaen el manejo de los tumores neuroendocrinos en elServicio de Oncología del Centro Médico Nacional “20de noviembre”, ISSSTE, en los últimos 10 años. Gamo.2012; 11: 18-28.
Kumar T, Gupta B, Das P, Madhusudhan KS. The rare caseof a cystic pancreatic neuroendocrine tumor. Autops CaseRep. 2020; 10: e2020171. doi: 10.4322/acr.2020.171.
Lira-Treviño A, Carranza-Mendoza IG, Borbolla-Arizti JP,Soriano-Ríos A, Uscanga-Domínguez L, Peláez-Luna M.Lesiones quísticas de páncreas. Diagnóstico diferencial yestrategia de tratamiento. Rev Gastroenterol Mex. 2022; 87:188-197.
Coban S, Basar O, Brugge WR. Pancreatic cystic neoplasms.Gastroenterol Clin North Am. 2022; 51: 537-559. doi:10.1016/j.gtc.2022.06.008.
Pai s -Costa SR, Sousa GCC, Araujo SLM, LimaOAT, Martins SJ, Torres OJ. Laparoscopic distalpancreatectomy with or without spleen preservation:comparative analysis of short and long-term outcomes.Arq Bras Cir Dig. 2019; 32: e1461. doi: 10.1590/0102-672020190001e1461.
National Comprehensive Cancer Network (NCCN).NCCN Clinical Practice Guidelines in Oncology:Neuroendocrine and Adrenal Tumors. Version 3.2025.Available at: https://www.nccn.org/guidelines/guidelinesdetail?category=1&id=1448
Cheng Y, Zhan H, Wang L, Zhang S, Ma J, Jiang Het al. Analysis of 100 consecutive cases of resectablepancreatic neuroendocrine neoplasms: clinicopathologicalcharacteristics and long-term outcomes. Front Med. 2016;
10: 444-450. doi: 10.1007/s11684-016-0471-x.10. Gutiérrez BD, Apodaca-Rueda M, Maeda CT, CarvalhoCGC, Baker E, Martinie JB et al. Indications andtechniques for minimally invasive spleen-preserving distalpancreatectomy. World J Gastrointest Surg. 2025; 17:109774. doi: 10.4240/wjgs.v17.i10.109774.
Abu Hilal M, Carvalho L, Van Ramshorst TME, Ramera M.Minimally invasive vessel-preservation spleen preservingdistal pancreatectomy-how I do it, tips and tricks andclinical results. Surg Endosc. 2023; 37: 7024-7038. doi:10.1007/s00464-023-10173-z.
Kaosombatwattana U, Hirooka Y, Kawashima H, Ohno E,Ishikawa T, Suhara H et al. Neuroendocrine neoplasm ofpancreas with cystic degeneration mimicking mucinouscystic neoplasm. Clin J Gastroenterol. 2018; 11: 333-337.doi: 10.1007/s12328-018-0846-4
Nguyen H, Luong TH, Nguyen AK, Nguyen TK.Laparoscopic antegrade spleen-preserving distal pancreatectomy with conservation of the splenic vessels:a prospective multi-centre case series (with video). AnnMed Surg (Lond). 2024; 86: 3211-3215. doi: 10.1097/MS9.0000000000002059.
Hang K, Zhou L, Liu H, Huang Y, Zhang H, Tan C et al.Splenic vessels preserving versus Warshaw technique inspleen preserving distal pancreatectomy: a systematicreview and meta-analysis. Int J Surg. 2022; 103: 106686.doi: 10.1016/j.ijsu.2022.106686.
Kiemen AL, Young ED, Blackford AL, Wu P, Burkhart RA,Burns WR et al. Prognostic features in surgically resected welldifferentiatedpancreatic neuroendocrine tumors: an analysisof 904 patients with 7882 person-years of follow-up. EndocrPathol. 2025; 36: 24. doi: 10.1007/s12022-025-09866-z.