Rodríguez-López M, Negro-Ocampo N, Campos-García FJ

Language: Spanish
References: 8
Page: 171-175
PDF size: 1525.59 Kb.

ABSTRACT

Introduction: extranodal NK/T-cell lymphoma, nasal type (ENKTL), is an aggressive neoplasm that is rare in the pediatric population and associated with the Epstein-Barr virus (EBV). In general, the prognosis for these patients is poor; the nonspecific clinical presentation often leads to delayed diagnosis and progression to advanced stages of the disease. Clinical case: we present the case of a 12-year-old patient with persistent fever, weight loss, and an exophytic lesion located on the soft palate and pharynx, with minimal nasal involvement. The patient received multiple antimicrobial treatments over five months without improvement. A biopsy was performed, and histopathology confirmed ENKTL; EBV positivity was also documented. Staging studies revealed central nervous system infiltration but no bone marrow involvement, classifying the disease as stage IV. The patient was treated with the SMILE chemotherapy regimen, followed by CHOP consolidation and hematopoietic stem cell transplantation, achieving complete remission. After five years of follow-up, the patient remains disease-free. Conclusions: ENKTL should be considered in the differential diagnosis of persistent lesions of the upper aerodigestive tract that do not respond to conventional treatment. Early biopsy, timely histopathological diagnosis, and multidisciplinary treatment can improve prognosis, even in patients with advanced disease.

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