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2003, Number 2

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Med Sur 2003; 10 (2)

Immune thrombocytopenic purpura

Gomar HM, Chávez-Tapia NC, Lizardi CJ
Full text How to cite this article

Language: Spanish
References: 4
Page: 97-100
PDF size: 58.24 Kb.


Key words:

Immune thrombocytopenic purpura..

ABSTRACT

A 52-year-old woman with immune thrombocytopenic purpura diagnosed nine years ago has presented two recurrencies relieved to immunossupressant treatment. The last one did not havea good response to corticosteroids and require intravenous immune globulin and anti-D immune globulin. She was found to have thrombocytopenia (18,000 mm3/µL) and she had two hematomas without other bleeding symptoms. Her blood analysis showed mild anemia. No other laboratory abnormalities are identified. Immune thrombocytopenic purpura is an autoimmune disorder characterized by a low platelet count and mucocutaneous bleeding. It is classified as primary or secondary due an underlying disorder and acute (of six months or less in duration) or chronic. Immune thrombocytopenic purpura in adults is chronic, the woman are affected twice than man. This review focuses on the diagnosis and management of primary immune thrombocytopenic purpura.


REFERENCES

  1. Cines DB, Blanchette VS, Chir B. Immune Thrombocytopenic Purpura. N Engl J Med 2002; 347: 449-450.

  2. George JN, el Harake MA, Aster RH. Thrombocytopenia due to enhanced platelet destruction by immunologic mechanisms. In: Beutler E, Lichtmann MA, Coller BA, Kipps TJ, eds. Williams Hematology. 5th ed. New York: McGraw-Hill, 1995: 1315-55.

  3. Kuwana M, Kawakami Y, Ikeda Y. Suppression of autoreactive T-cell response to glycoprotein IIb/IIIa by blockade of CD40/CD154 interaction: implications for treatment of immune thrombocytopenic purpura. Blood 2003; 101: 621-623.

  4. Di Paola JA. Immune thrombocytopenic purpura. Pediatr Clin North Am 49(5): 911-28.




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C?MO CITAR (Vancouver)

Med Sur. 2003;10