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2003, Number 4

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Med Sur 2003; 10 (4)

Diagnosis methods in pulmonary thromboembolism

Romero K, Chávez TNC, Lizardi-Cervera J
Full text How to cite this article

Language: Spanish
References: 8
Page: 167-172
PDF size: 61.41 Kb.


Key words:

Pulmonary embolism (PE), D- dimer (DD)..

ABSTRACT

The pulmonary embolism (PE) is a common disorder that is accompanied by significant morbidity and mortality. It has been estimated that PE occurs in approximately 600,000 patients annually in the United States and causes 50,000 to 200,00 deaths. At least 1% of hospitalized patients suffer an acute pulmonary embolism, being even higher in patients admitted to geriatric units. The true incidence of PE is unknown, however, because its many nonspecific clinical features produce one of the most difficult diagnostic challenges in all of medicine. The elderly are at increased risk for both venous thrombosis and pulmonary embolism. It is unclear, however, whether age is an independent risk factor for thrombus formation, or whether the elderly simply have a high incidence of conditions associated with venous thromboembolic disease. The hemodynamic impact of pulmonary embolism is more severe in elderly patients with pre-existing cardiopulmonary disease, and the risk of bleeding from this treatment also increases with age. Thus, pulmonary embolism is a particularly challenging problem in older people. The measurement of D-dimer has become a frequently requested laboratory test in the study of PE even though in many cases its real interpretation is unknown. The main objective of this review is know the diagnostic tools for PE, with main emphasis in measurement of D-dimer.


REFERENCES

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  2. Fedullo PF, Tapson VF. The evaluation of suspected pulmonary embolism. N Engl J Med 2003; 349: 1247-56.

  3. Brotman DJ, Segal JB. Limitations of D-dimer testing in unselected in patients with suspected venous thromboembolism. Am J Med 2003; 14; 276-82.

  4. Brown MD, Rowe BH. The accuracy of the enzyme-linked immunosorbent assay D-dimer test in the diagnosis of pulmonary embolism: A meta-analysis. Ann Emerg Med 2002; 40: 133-44.

  5. Ginsberg J, Brill-Edwards P, Demers C et al. D-dimer in patients with clinically suspected pulmonary embolism. Chest 1993; 104: 1679-1684.

  6. Berman AR. Pulmonary embolism in the elderly. Clin Geriatric Med 2001; 17(1); 107-30.

  7. Stein PD, Gottschalk A, Saltzman HA et al. Diagnosis of acute pulmonary embolism in the elderly. J Am Coll Cardiol 1991; 18: 1452.

  8. Wells et al. Derivation of a simple clinical model to categorize patients´probability or pulmonary embolism: increasing the model´s utility with the SimpliRED D-dimer. Thromb Haemost 2000; 83: 416-420.




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Med Sur. 2003;10