Solís OCA, Muñoz CM

Language: Spanish
References: 19
Page: 109-118
PDF size: 125.15 Kb.

ABSTRACT

Objectives: To describe the prevalence of the main cardiovascular risk factors in a group of patients from Northeast of Mexico evaluated for suspect of coronary artery disease. Methods: A cross sectional and comparative study in 239 patients divided after non invasive evaluation into 2 groups: 1 = Patients without myocardial ischemic disease. 2 = Patients with myocardial ischemic disease. Inclusion criteria: a) Patients with suspected symptoms of coronary artery disease. b) Asymptomatic patients with abnormal electrocardiogram. Exclusion criteria: a) Patients with physical incapacity, b) severe systemic disease or advanced cancer, c) acute coronary syndrome, d) severe systolic left ventricular dysfunction e) patients in active lipid lowering therapy one month ago. Statistical: Descriptive analysis. Prevalence and frequencies are expressed in term of percentage. Statistical proof, cross tabulation and chi-square were employed. All the statistical analysis was conducted in SPSS for Windows. Significancy level ≤ 0.05. Results: Prevalence obtained are: hypercholesterolemia › 200 mg/dL, 58.4%. hypertrigliceridemia › 200 mg/dL, 42.8%. Low levels of HDL-C ‹ 40 mg/dL, 47.89%. Means levels cholesterol in 212.5 mg/dL and LDL-C, 131.2 mg/dL. Mean triglycerides in 211.1 mg/dL and HDL-C, 41.06 mg/dL. For hypertension and diabetes, 49.5% and 25.2%. Mean body mass index in 29. Obesity with body mass index › 30, 40%. Smokers, 30.6% and metabolic syndrome, 51.2%. In the ischemic group, the average age was higher than other group (68.85 vs 54.55), p= 0.0000405. The age 60 years or more, p = 0.0003, male sex, p = 0.001, smokers, p = 0.0094 and diabetes, p = 0.05, showed significant relation with the ischemic group. Conclusion: Our data reveal a high prevalence of insulin resistance clinical factors and metabolic syndrome in patients of Northeast of Mexico evaluated in a Cardiology Service. Beyond cholesterol levels, the metabolic syndrome is outlined like one of the mainly cardiovascular risk factors in our environment.

REFERENCES

1. Sania N. Prevention of coronary heart disease in south Asia. Lancet 2002; 360: 1015-1018.

2. Luc G, Bard JM, Ferrieres J, Evans A, Amouyel P, Arveiler D et al. Value of HDL cholesterol, apolipoprotein A-I, lipoprotein A-I, and lipoprotein A-I/A-II in prediction of coronary heart disease. The PRIME study. Arterioscler Thromb Vasc Biol 2002; 22: 1155-1161.

3. Sundquist J, Winkleby MA. Cardiovascular risk factors in Mexican American adults: a transcultural analysis of NHANES III, 1988-1994. Am J Public Health 1999; 89: 723-730.

4. Bhopal R, Unwin N, White M, Yallop J, Walker L, Alberti KG et al. Heterogeneity of coronary heart disease risk factors in Indian, Pakistani, Bangladeshi, and European origin populations: cross sectional study. BMJ 1999; 319: 215-220.

5. Whincup P, Gilg J, Papacosta O, Seymour C, Miller G, Alberti KG et al. Early evidence of ethnic differences in cardiovascular risk: cross sectional comparison of British South Asian and white children. BMJ 2002; 324: 635-638.

6. Braunwald E. Shattuck lecture- Cardiovascular Medicine at the turn of the millennium: Triumphs, concerns, and opportunities. N Engl J Med 1997; 337: 1360-1369.

7. Escobedo de la Peña J, Escamilla Cejudo J, Santos-Burgoa C. Colesterol sérico y diabetes mellitus: principales factores de riesgo independientes en la mortalidad por cardiopatía isquémica en México. Arch Inst Cardiol Méx 1994; 64: 189-195.

8. Meigs JB, Wilson PW, Nathan DM, D´Agostino RB, Williams K, Haffner SM. Prevalence and characteristics of the metabolic syndrome in San Antonio Heart and Framingham Offspring studies. Diabetes 2003; 52: 2160-2167.

9. Velásquez-Monroy O, Rosas M, Lara A, Pastelín G, Castillo C, Attie F y cols. Prevalencia e interrelación de enfermedades crónicas no transmisibles y factores de riesgo cardiovascular en México: Resultados finales de la Encuesta Nacional de Salud (ENSA) 2000. Arch Cardiol Mex 2003; 73: 62-77.

10. Masiá R, Pena A, Marrugat J, Sala J, Vila J, Pavesi M et al. High prevalence of cardiovascular risk factors in Gerona, Spain, a province with low myocardial infarction incidence. J Epidemiol Community Health 1998; 52: 707-715.

11. Segura FA, Rius MG. Factores de riesgo cardiovascular en una población rural de Castilla-La Mancha. Rev Esp Cardiol 1999; 52: 577-588.

12. Harland JO, Unwin N, Bhopal RS, White M, Watson B, Laker M et al. Low levels of cardiovascular risk factors and coronary heart disease in a UK Chinese population. J Epidemiol Community Health 1997; 51: 636-642.

13. Després JP, Lemieux I, Dagenais GR, Cantin B, Lamarche B. Evaluation and management of atherogenic dyslipidemia: beyond low-density lipoprotein cholesterol. CMAJ 2001; 165: 1331-1333.

14. Ridker PM, Rifai N, Clearfield M, Downs JR, Weis SE, Miles S et al. Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events. N Engl J Med 2001; 344: 1959-1965.

15. Hernández CA. Mortalidad por cardiopatía isquémica en Cuba. Relación con la dieta y el colesterol sérico. Rev Cubana Cardiol Cir Cardiovasc 1999; 13(1): 8-12.

16. Aguilar-Salinas C, Olaiz G, Valles V, Ríos J, Gómez F, Rull J et al. High prevalence of low HDL cholesterol concentrations and mixed hyperlipidemia in a Mexican nationwide survey. J Lipid Res 2001; 42: 1298-1307.

17. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults. Findings from the Third National Health and Nutrition Examination Survey. JAMA 2002; 287: 356-359.

18. Balaguer VI. Control y prevención de las enfermedades cardiovasculares en el mundo. Rev Esp Cardiol 2004; 57: 487-494.

19. Lara A, Rosas M, Pastelín G, Aguilar C, Attie F, Velásquez O. Hipercolesterolemia e hipertensión arterial en México. Consolidación urbana actual con obesidad, diabetes y tabaquismo. Arch Cardiol Mex 2004; 74: 231-245.