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ISSN 0185-6014 (Print)
Órgano oficial de difusión de la Federación Mexicana de Patología Clínica, AC y de la Asociación Latinoamericana de Patología Clínica/Medicina de Laboratorio

2007, Number 4

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Rev Mex Patol Clin Med Lab 2007; 54 (4)

Illustrated monographs of clinical pathology Uncinariasis: life cycle, clinical records, pathophysiology and animal models

Carrada-Bravo T

Language: Spanish
References: 50
Page: 187-199
PDF size: 355.80 Kb.


ABSTRACT

Human hookworm is caused by infection with the helminth nematode parasites Necator americanus and Ancylostoma duodenale and is transmitted through contact with soils of the rural tropics and subtropics. The highest rates of hookworm disease occur in the coastal-humid regions, in these areas, repeated exposure to third-stage lavar of Necator results in a local pruritic, erythematous, papular rash of the feet and hands. After entry through the skin the larvae migrates to the lungs resulting in cough, sore throat, eosinophilia and increased circulating levels of IgE. However major injury in humans occurs when the adult parasite cause intestinal blood loss with iron-deficiency anemia and hypoalbuminemia, and when the hookworm intestinal burden reaches 40 to 160 adult parasites, the hemoglobin level is below 11 g per deciliter/blood. In children, chronic hookworm disease retards physical growth. Severe anemia during pregnancy has been linked to maternal mortality, impaired lactation, prematury and low birth weight. This paper reviews the hookworm’s life cycle, clinical manifestation, pathogenesis and the recent advances in the use of animal models.


REFERENCES

  1. Botero D, Restrepo M. Uncinariasis. En: Bootero D, Restrepo M. Parasitosis humanas. 2a ed. Medellín, Colombia: Ed Corporación para Investigaciones Biológicas, 1994; 96-106.

  2. Carrada–Bravo T. Las parasitosis humanas en México. Bol Med Hosp Infant Mex 1985; 42: 73-78.

  3. Carrada-Bravo T. La uncinariasis Avances y perspectivas, Epidemiología y Diagnóstico. Rev Mex Pediatr 1984; 51: 157-170.

  4. Carrada–Bravo T. Uncinariosis infantil como problema de salud pública. Bol Med Hosp Infant Mex 1986; 43; 789-794.

  5. Belding DL. Textbook of Parasitology. 3a ed. Nueva York: Meredith Pub, 1965; 424-425.

  6. Hotez OJ, Brooker S, Bethony JM, Bottazzi ME, Loukas A, Xiao S. Hookworm Infection, current concepts. N Engl J Med 2004; 351: 799-807.

  7. Beaver P Ch, Jung RC, Cupp EW. Clinical Parasitology. 9a ed. Filadelfia: Lea and Febiger, 1984; 269-287.

  8. Schad GA. Hookworms. En: Warren KS, Mahmoud AF. Tropical and Geographical Medicine. 2a ed. New York: McGraw-Hill, 1990; 379-392.

  9. Apt W. Helmintiasis intestinales humanas en América Latina. Prevalencia actual y factores contribuyentes. Parasitología al día 1987; 11: 155-166.

  10. Hotez PJ. Hookworm disease in children. Pediatr Infect Dis 1989; 8: 516-520.

  11. Anderson RM, Schad GA. Hookworm burdens and fecal egg counts: An analysis of the biological basis of variation. Trans R Soc Trop Med Hyg 1985; 79: 812-825.

  12. Stolzfus RJ, Chwaya HM, Tielsch JM, Schulze KJ, Albonico M, Salvioli L. Epidemiology of iron deficiency anemia in Zanzibari schoolchildren: the importance of hookworm. Amer J Clin Nut 1997; 65: 153-159.

  13. Udoski JK. Necator americanus infection: A cross-sectorial study of a rural community in relation to some clinical symptoms. Ann Trop Med Parasitol 1980; 78: 443-444.

  14. Canese JH. Estado actual de los estudios sobre la uncinariasis en el Paraguay. Ann Fac Cienc Med Univ Nac Asunción 1992; 4: 117-162.

  15. Hernández–Lira J. Distribución geográfica y patología de la uncinariasis en la República Mexicana. Bol Epidemiol (Mex) 1949; 13: 111-115.

  16. Martuscelli QA. Frecuencia de las parasitosis intestinales en niños de la República Mexicana. Rev Mex Pediatr 1967; 36: 111-122.

  17. Tay J, Ruiz A, Sánchez Vega JT, Romero Cabello R, Robert L, Becerril MA. Helmintiasis intestinal en la República Mexicana. Bol Chil Parasitol 1995; 50: 10-16.

  18. Bradley M, Chandiwana SK, Bundy DAP. The epidemiology and control of hookworm infection in the Burma Valley area in Zimbabwe. Trans R Soc Trop Med Hyg 1993; 87: 145-147.

  19. Carrada-Bravo T. Larva migrans cutánea: Revisión del tema y descripción de cuatro casos. Med Inter Mex 2006; 22: 143-148.

  20. Hotez PJ, Pritchard DI. Hookworm infection. Sci Am 1995; 272: 68-74.

  21. Stranseens P, Bergum PW, Ganseman Y. Anticoagulant repertoire of the hookworm Ancylostoma caninum. Proc Natl Acad Sci USA 1996; 93: 2149-2154.

  22. Del Valle A, Jones BF, Harrison LM, Chadderson RC, Cappello M. Isolation and molecular cloning of a secreted hookworm platelet inhibitor from adult Ancylostoma caninum. Mol Biochem Parasitol 2003; 129: 167-177.

  23. Gustberg TW, Hensley LE, Jahrling PB. Treatment of Ebola virus infection with recombinant inhibitor of factor: A study in rhesus monkey. Lancet 2003; 362: 1953-1958.

  24. Williamson AL, Brindley PJ, Knox DP, Hotez PJ, Loukas A. Digestive proteasas of blood–feeding nematodes. Trends Parasitol 2003; 19: 417-423.

  25. Stoltfuss RJ, Dreyfuss ML, Chwaya HM, Albónico M. Hookworm control as a strategy to prevent iron deficiency. Nutr Rev 1997; 55: 223-232.

  26. Lwambo NJ, Bundy DA, Medley GF. A new approach to morbidity risk assessment in hookworm endemic communities. Epidemiol Infect 1992; 108: 469-481.

  27. Bundy DA, Chan MS, Savioli L. Hookworm infection in pregnancy. Trans R Soc Trop Med Hyg 1995; 89: 521-522.

  28. Azuara J, Martuscelli A. Uncinariasis en lactantes y preescolares. Presentación de un caso de dos meses de edad. Rev Mex Pediatr 1967; 34: 146-149.

  29. Bestard JJ, Bellasi J, Chamorro LA, Garcete L, Zacur M, Richer Y et al. Uncinariasis en el lactante. Bol Med Hosp Infant Mex 1990; 47: 376-381.

  30. Gilles HM, Williams EJ, Ball PA. Hookworm infection and anaemia: An epidemiological, clinical and laboratory study. QJ Med 1964; 331: 1-24.

  31. Sakti H, Nokes C, Hertano WS. Evidence for an association between hookworm infection and cognitive function in Indonesian school children. Trop Med Int Health 1999; 4: 322-334.

  32. Nacher M, Singhasivanon P, Traore B. Short report: Hookworm infection is associated with decreased body temperature during mild Plasmodium falciparum malaria. Am J Trop Med Hyg 2001; 65: 136-137.

  33. Smille WG, Spencer CR. Mental retardation in school children infested with hookworm. J Educ Psycol 1926; 17: 314-321.

  34. Brooker S, Peshu N, Warn PA. Epidemiology of hookworm infection and its contribution to anemia among pre-school children on the Kenian coast. Trans R Soc Trop Med Hyg 1999; 93: 240-246.

  35. Miller TA. Hookworm infection in man. Advances in Prasitology 1979; 17: 315-353.

  36. Banwell JG, Schad GA. Hookworms Clinics in Gastroenterology 1978; 7: 129-156.

  37. Yoshida Y, Fukutone S. Experimental infection in rabbits with the hookworm Necator americanus. J Parasitol 1967; 53: 1067-1074.

  38. Sen HG. Necator americanus: Behavior in hamsters. Experimental Parasitol 1972; 32: 26-32.

  39. Soh CT. The distribution and persistence of hookworm larvae in the tissues of mice in relation to species and routes of inoculation. J Parasitol 1958; 44: 515-519.

  40. Wilkinson MJ, Wells C, Behnke JM. Necator americanus in the mouse: Histopathological changes associated with the passage of larvae through the lungs of mice exposed to primary and secondary infection. Parasitol Res 1990; 76: 386-392.

  41. D’ Abrera VSt E. The aetiology of “tropical eosinophilia” with a preliminary note on the pathology of the syndrome. Ceylon Med J 1958; 4: 195-210.

  42. Harada Y. Wakana disease and hookworm allergy. Yonago Acta Med 1962; 6: 109-118.

  43. Komiya Y, Yasuraoka K. The biology of hookworms. Prog Parasitol Jpn 1966; 3: 1-114.

  44. Bethony J, Loukas A, Smout M, Brooker S, Mendez S, Pliestkatt J et al. Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals. Faseb J 2005; Julio 21. 10.1096/fj. 05–3936.

  45. Xue J, Qiang HQ, Yao J, Fuyowara R, Zhan B, Hotes P et al. Necator americanus: Optimization of the golden hamster model for testing antihelmintic drugs. Experimental Parasitol 2005; 111: 219-223 (www.Sciencedirect.com)

  46. Pritchard DIE, Quinnel R, Walsh E. Immunity to humans in Necator americanus IgE parasite weight and fecundity. Parasite Immunol 1995; 17: 71-82.

  47. Prociv P. Pathogenesis of human hookworm infection: Insights from a new zoonosis. Chem Immunol 1997; 66: 62-73.

  48. Hsieh GC, Loukas A, Wahl A, Bhatia M, Wang Y, Williamson AL et al. Secreted proteins from the human hookworm Necator americanus binds selectively to NK cells and induces IFN-production. J Immunol 2004; 173: 2699-2704.

  49. Behnke HM, Pritchard DI. Necator americanus: In neonatally infected hamsters. The time course of infection and antibody response to the surface antigens of L–4 and adult worms. Trans R Soc Trop Med Hyg 1987; 81: 967-972.

  50. Gilles HM. Selective primary health: Strategies for control of disease in the developing world XVII. Hookworm infection and anemia. Rev Infect Dis 1985; 7: 111-118.




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