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Revista Mexicana de Neurociencia

Academia Mexicana de Neurología, A.C.
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2006, Number 2

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Rev Mex Neuroci 2006; 7 (2)

Blood and marrow stem cells transplantation in multiple sclerosis. Present and future in its use and selection of patients

Skromne EE, Rivera OVM, Ordoñez BL, Ontaneda JD
Full text How to cite this article

Language: Spanish
References: 9
Page: 164-169
PDF size: 70.20 Kb.


Key words:

Blood and marrow stem cells transplantation, multiple sclerosis.

ABSTRACT

Multiple sclerosis (MS) is a disease with an autoinmune pathophysiology. A new and promising treatment in this group of patients is the blood and marrow stem cells transplantation which is currently an experimental treatment with evident immuno-suppressant effects. It has not been demonstrated any effect on neurodegeneration and it is preferred to use this procedure as a non-conventional treatment of multiple sclerosis. Selection of patients should be strict, mainly in patients with moderate severity and an important inflammatory component. It is not a rescue treatment because its utility in progressive forms or advanced MS has not been demonstrated and the risk is high. This review includes an analysis of the current protocols and their results.


REFERENCES

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  6. Openshaw H, Lund BT, Kashyap, et al. Peripheral blood stem cell transplantation in multiple sclerosis with busulfan and cyclophosphamide conditioning: Report of toxicity and immunological monitoring. Biol Blood Marrow Transplant 2000; 6: 563-75.

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  8. Comi L, Kappos M, Clanet G, Ebers A, Fassas, et al. Guidelines for autologous blood and marrow stem cell transplantation in multiple sclerosis: a consensus report written on behalf of the European Group for Blood and Marrow Transplantation and the European Charcot Foundation. J Neurology 2000; 247: 376-82.

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Rev Mex Neuroci. 2006;7