2007, Number 3
Rev Mex Coloproctol 2007; 13 (3)
Prevalence of subtypes of the HPV patients with anal condyloma
Márquez GJJ, Santamaría EJ, Cocotle RBE, Hernández OC, Berinstain CE, Escalera CM, Márquez SI, Santamaría SJ
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Language: Spanish
References: 19
Page: 80-86
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ABSTRACT
The infection of the human papillomavirus (HPV) was a well known disease by the Greeks and the Romans of the ancient times, whom already spoke of Condyloma (from the Greek word Konduloma (callous lumb), meaning knuckle or knob for its likeness. It is an infection that at the moment is among the most frequently sexually transmitted illnesses in the world. It occurs as much in man as in women, regardless their sexual preference, although it does prevail in the group of homosexual men. The inoculation of the HPV obeys primarily to the sexual contact, in micro cuts mainly in the tissues in genital organs and skin, taking place by the friction produced during sexual intercourse. There are quite many other forms of infections but they are questioned. More than 100 subtypes of the HPV have been identified, from which approximately 40 of them are associated with injuries in the genital dermis, intraepithelial and invaders. The subtypes that may cause the infection are divided in two big groups according with their potentiality in getting associated with pre-malignant neoplasia and cancer. They are categorized in high and low risk. The clinical behavior of the injuries produced by the virus depends on the viral subtype, the immunological state of the host and the place of the implantation. Several risk factors exist to acquire the HPV infection; its persistence and its developing capacity into cancer: Among them are the high number of sexual partners and the beginning of the sexual life at early age, with a increased number of cofactors that assist the persistence of the infection, such as the feeding habits, multiparity, herpes caused infections, Chlamydia, cigarette smoking, alterations in the immunological state cause by HIV/aids or other type of diseases and situations of immunosuppression, like transplants and long term use of contraceptives in case of women. A special research was developed in linking between the faculty of medicine of the Universidad Veracruzana, campus Xalapa, Veracruz and the regional hospital Dr. Luis F. Nachón in the same city, its objective was to determine the prevalence of the oncogenic serotypes of the HPV, as well as the clinical behavior of the anogenital injuries in relation to the viral subtype within the patients carriers of the anal Condylomata that attended to a special check up at the Hospital before mentioned in the period of time from January 1st 2005 to December 31st 2006. Thirty patients, presenting the symptoms of criteria for inclusion, were selected aleatory, ranging the ages from 13 to 63 years, all of them with injuries exclusively in the anal, perianal and perineal regions. The Polymerase chain reaction (PCR) techniques were applied to the patients previously to their treatment to determine the specific viral subtype of the HPV. The surgery by biopsy plus electrofulguration was the method selected for the treatment in all patients. The following was in a period of time from two months to two years in observation and control. Relapses of warts were noticed within three of the patients, those lesions were eliminated by electrofulguration under local anesthesia. One patient died as a consequence of his pathology base.REFERENCES