>Cirugía y Cirujanos
>Year 2008, Issue 1
Roesch-Dietlen F, Pérez-Morales A, Melo-Santisteban G, Díaz-Blanco F, Martínez JÁ, Cid-Juárez S
Frequency and clinical, biochemical and histological characteristics of nonalcoholic fatty liver disease in patients with gallstone disease
Cir Cir 2008; 76 (1)
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Background: In 1980, nonalcoholic fatty liver disease (NALFD) was described. It is related to the genesis of gallstones, and for this reason is considered as a manifestation of the metabolic syndrome. In order to determine the frequency, anatomoclinical characteristics and biochemical and histological alterations in NAFLD, patients underwent cholecystectomy and, for this reason, we considered carrying out this study.
Methods: This was a prospective and observational study. The study population was comprised of patients with gallstone disease who were treated at the “Hospital Español” in Veracruz, Mexico from January 1, 2005 to November 30, 2006 and underwent cholecystectomy and liver biopsy. Analyzed variables were anthropometric characteristics and risk factors, and in each patient biochemical tests, abdominal ultrasound and histological liver study were performed.
Results: In 95 patients, according to liver biopsy diagnoses, we found a frequency of 54.74 % of NAFLD associated with gallstones. Females were more affected (71.15 %) and the average age was 55.6 ± 17.87 years. Risk factors were obesity (67.3 %), diabetes mellitus (17.3 %), and dyslipidemia (76.92 %). Patients with NAFLD had elevated levels of glucose, glycosylated hemoglobin, cholesterol, triglycerides and HDL-cholesterol, and aminotransferases. Abdominal ultrasound did not show sufficient specificity and sensitivity to detect NAFLD. Histological findings showed stage I steatosis in 51.93 %, stage II in 28.84 % and stage III in 19.23%. Cirrhosis was found in 3.15 %.
Discussion: Results of our study confirm the high frequency of NAFLD in association with gallstone disease. We consider this the first work to analyze and describe the primary clinical, biochemical and morphological characteristics.
||Nonalcoholic fatty liver disease, cholelithiasis.
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>Cirugía y Cirujanos
>Year 2008, Issue 1