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>Journals >Medicina Crítica >Year 2008, Issue 2

Carrillo ER, Carrillo CLD, Carrillo CJR, Uribe RM, González ÁD
Serotonin syndrome at the Intensive Care Unit. A case report and literature review
Rev Asoc Mex Med Crit y Ter Int 2008; 22 (2)

Language: Español
References: 36
Page: 93-98
PDF: 95.81 Kb.

Full text


Introduction: The serotonin syndrome results when serotoninergic activity increases to abnormally high levels. It occurs with selective serotonin reuptake inhibitors, opioids, some antibiotics, and other serotoninergic agents when the serotonin system has been modulated by another serotoninergic agent or compromised by illness. Although the symptoms are quite variable, the syndrome is characterized by a triad of altered mental status, neuromuscular abnormalities, and autonomic dysfunction.
Case report: A case of Serotonin syndrome is presented, related to the combination of linezolide, tramadol and olanzapine. The patient had a favourable outcome employing cyproheptadine and support measures.
Conclusions: The physiopathology, diagnosis, differential diagnosis and the treatment of serotoninergic syndrome are review. We emphasize the potentially high frequency of this disorder in the Intensive Care Unit.

Key words: Serotonin syndrome, linezolide, tramadol, cyproheptadine, Intensive Care Unit.


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>Journals >Medicina Crítica >Year 2008, Issue 2

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